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Perphenazine solution


Generic Name: perphenazine (per-FEN-a-zeen)
Brand Name: Generic only. No brands available.

Perphenazine solution is used for:

Treating schizophrenia. It may also be used to treat severe nausea and vomiting. It may also be used for other conditions as determined by your doctor.

Perphenazine solution is an antipsychotic. It works by blocking dopamine receptors in the brain.

Do NOT use perphenazine solution if:

  • you are allergic to any ingredient in perphenazine solution
  • you have certain types of brain damage
  • you have blood disorders, liver damage, or decreased bone marrow function
  • you are taking astemizole, cisapride, terfenadine, or tramadol

Contact your doctor or health care provider right away if any of these apply to you.

Before using perphenazine solution:

Some medical conditions may interact with perphenazine solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of seizures, breast cancer, asthma, trouble urinating, lung problems (eg, emphysema), alcohol abuse, or depression
  • if you have a lung infection, heart or blood disease, Reye syndrome, Parkinson disease, glaucoma, high or low blood pressure, or prostate problems

Some MEDICINES MAY INTERACT with perphenazine solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, benztropine), antihistamines (eg, diphenhydramine), barbiturates (eg, phenobarbital), opiates (eg, codeine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of perphenazine solution's side effects
  • Astemizole, cisapride, haloperidol, ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, erythromycin), pimozide, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), terfenadine, or tramadol because the risk of severe heart, nervous system, or muscle problems or seizures may be increased
  • Guanethidine, levodopa, or pergolide because their effectiveness may be decreased by perphenazine solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if perphenazine solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use perphenazine solution:

Use perphenazine solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take perphenazine solution by mouth with or without food.
  • Mix perphenazine solution with about 2 ounces (59 mL) of water; milk; or pineapple, apricot, prune, orange, tomato, or grapefruit juice and swallow the mixture. Do NOT mix perphenazine solution with caffeine-containing liquids (eg, coffee, cola), tea, or apple juice because it may prevent the medicine from working. Ask your health care provider any questions you may have about mixing perphenazine solution.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you spill perphenazine solution on your skin, wash it off right away with soap and water.
  • If you miss a dose of perphenazine solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use perphenazine solution.

Important safety information:

  • Perphenazine solution may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use perphenazine solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using perphenazine solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Perphenazine solution may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Perphenazine solution may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to perphenazine solution. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by perphenazine solution. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Some patients who take perphenazine solution may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take perphenazine solution in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking perphenazine solution.
  • Tell your doctor or dentist that you take perphenazine solution before you receive any medical or dental care, emergency care, or surgery.
  • Use perphenazine solution with caution in the ELDERLY; they may be more sensitive to its effects.
  • Perphenazine solution should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using perphenazine solution while you are pregnant. Perphenazine solution is found in breast milk. If you are or will be breast-feeding while you use perphenazine solution, check with your doctor. Discuss any possible risks to your baby.

If you stop taking perphenazine solution suddenly, you may have WITHDRAWAL symptoms. These may include unpleasant feelings. In more severe cases, stomach and muscle cramps, vomiting, sweating, shakiness, and, rarely, seizures may occur.

Possible side effects of perphenazine solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; blurred vision; confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; nasal congestion; nausea; sleeplessness; tired feeling; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in breasts; changes in menstrual period; changes in vision; difficulty speaking; difficulty swallowing; inability to move eyes; lip smacking or puckering; mask-like face; mental confusion; muscle spasms of face, neck, or back; numbness of the arms and legs; prolonged or painful erection; puffing of cheeks; restlessness; seizures; shuffling walk or stiff arms or legs; sore throat; tension in leg; tightness in the throat or jaw; tremors of hands; twitching or twisting movements; vision problems; weakness of arms or legs.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching.

Proper storage of perphenazine solution:

Store perphenazine solution between 36 and 86 degrees F (2 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep perphenazine solution out of the reach of children and away from pets.

General information:

  • If you have any questions about perphenazine solution, please talk with your doctor, pharmacist, or other health care provider.
  • Perphenazine solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about perphenazine solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Review Date: July 5, 2017

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.