Ethinyl Estradiol and Etonogestrel
Generic Name: Ethinyl Estradiol and Etonogestrel (ETH in il es tra DYE ole & et oh noe JES trel)
Brand Name: NuvaRing
Medically reviewed on Sep 5, 2018
- Smoking cigarettes while using ethinyl estradiol and etonogestrel raises the chance of very bad heart and blood-related side effects. This chance is raised with age (mainly in women older than 35 years of age). It is also raised with the number of cigarettes smoked. It is strongly advised not to smoke. Do not use ethinyl estradiol and etonogestrel if you smoke and are older than 35 years of age.
Uses of Ethinyl Estradiol and Etonogestrel:
- It is used to prevent pregnancy.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Ethinyl Estradiol and Etonogestrel?
- If you have an allergy to ethinyl estradiol, etonogestrel, or any other part of ethinyl estradiol and etonogestrel.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have had any of these health problems: Blood clots, blood clotting problem, breast cancer or other cancer where hormones make it grow, diseased blood vessels in the brain or heart, disease of a heart valve with problems, heart disease, chest pain caused by angina, heart attack, stroke, high blood pressure, liver disease, liver tumor, very bad headache or migraine, or diabetes that affects blood flow.
- If you have had any of these health problems: Endometrial cancer, cancer of the cervix or vagina, or vaginal bleeding where the cause is not known.
- If you have surgery and need bedrest.
- If you are taking ombitasvir, paritaprevir, and ritonavir (with or without dasabuvir).
- If you turned yellow during pregnancy or with estrogen-based or hormone contraceptive use.
- If you are pregnant or may be pregnant. Do not take ethinyl estradiol and etonogestrel if you are pregnant.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with ethinyl estradiol and etonogestrel.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take ethinyl estradiol and etonogestrel with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Ethinyl Estradiol and Etonogestrel?
- Tell all of your health care providers that you take ethinyl estradiol and etonogestrel. This includes your doctors, nurses, pharmacists, and dentists. This medicine may need to be stopped before certain types of surgery as your doctor has told you. If ethinyl estradiol and etonogestrel is stopped, your doctor will tell you when to start taking ethinyl estradiol and etonogestrel again after your surgery or procedure.
- Do not use a diaphragm, cervical cap, or female condom while using this ring.
- If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
- Check your blood sugar as you have been told by your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
- This medicine may raise the chance of blood clots, a stroke, or a heart attack. Talk with the doctor.
- Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.
- Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
- Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take ethinyl estradiol and etonogestrel.
- This medicine may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
- This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
- Check to see if ethinyl estradiol and etonogestrel is in place as you have been told by your doctor or read the package insert. If you cannot find the ring after putting it in or if you are not able to take it out, call your doctor right away.
- If the ring has come out and you do not know how long it has been, take a pregnancy test before putting in a new ring.
- Do not use in children who have not had their first menstrual period.
- If you have any signs of pregnancy or if you have a positive pregnancy test, call your doctor right away.
How is this medicine (Ethinyl Estradiol and Etonogestrel) best taken?
Use ethinyl estradiol and etonogestrel as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Follow how to use as you have been told by the doctor or read the package insert.
- Put into the vagina and leave in place for 3 weeks.
- Take out ring at the start of the 4th week.
- Put in a new ring 7 days later.
- Put it in at the same time of day that the one before was taken out.
- To use, wash your hands and take ring from the pouch. Keep the pouch to throw away the ring later.
- Be sure your hands are dry before you touch ethinyl estradiol and etonogestrel.
- Press sides of ring at the same time between thumb and index finger and put folded ring into the vagina.
- Perfect placement is not needed for the ring to work. The ring will not hurt.
- To take out, hook your index finger around the rim or hold rim between index finger and middle finger and pull out.
- Do not throw the vaginal ring in the toilet.
- If you miss 2 periods in a row, take a pregnancy test before starting a new cycle.
- If ethinyl estradiol and etonogestrel has not been used the right way and 1 monthly period is missed, take a pregnancy test.
- Certain drugs, herbal products, or health problems could cause ethinyl estradiol and etonogestrel to not work as well. Be sure your doctor knows about all of your drugs and health problems.
What do I do if I miss a dose?
- If the ring is taken out at any time during the 3 weeks of use, rinse it off with lukewarm water and put it back in as soon as you can.
- If the ring is taken out for more than 3 hours, you must use an extra kind of birth control also (not a diaphragm, cervical cap, or female condom) for 7 days after putting the ring back in.
- If the ring has been in for more than 4 weeks, it may not work as well. Talk with your doctor. You may need a pregnancy test to check if you are pregnant. Use an extra kind of birth control like a condom until you know you are not pregnant. After you know you are not pregnant, put in a new ring. Keep using the extra kind of birth control for 7 days.
- If the ring is out for more than 1 week, take a pregnancy test before starting the next dosing cycle.
- If a dose is missed, check the package insert or call the doctor to find out what to do. If using ethinyl estradiol and etonogestrel to prevent pregnancy, another form of birth control may need to be used for some time to prevent pregnancy.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; fever with chills; bloating; or very upset stomach or throwing up.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Low mood (depression).
- Mood changes.
- Feeling very tired or weak.
- Very bad belly pain.
- Not able to pass urine or change in how much urine is passed.
- Bulging eyes.
- Change in eyesight.
- Loss of eyesight.
- Change in how contact lenses feel in the eyes.
- Breast pain.
- A lump in the breast, breast soreness, or nipple discharge.
- Vaginal itching or discharge.
- Spotting or vaginal bleeding that is very bad or does not go away.
- Toxic shock syndrome (TSS) has happened in a few patients using vaginal rings. TSS is rare, but can be very bad and sometimes deadly. Tell your doctor right away if you have loose stools (diarrhea), dizziness or light-headedness, passing out, fever, muscle pain, upset stomach, throwing up, or a sunburn-like rash.
What are some other side effects of Ethinyl Estradiol and Etonogestrel?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Pimples (acne).
- Vaginal irritation.
- Weight gain.
- Upset stomach or throwing up.
- Stomach cramps.
- Belly pain.
- Enlarged breasts.
- Breast soreness.
- Lowered interest in sex.
- Period (menstrual) changes. These include spotting or bleeding between cycles.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Ethinyl Estradiol and Etonogestrel?
- Store unused rings at room temperature. Throw away any unused rings after 4 months.
- Do not use if ethinyl estradiol and etonogestrel is out of date.
- Protect from light.
- Protect from heat.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about ethinyl estradiol and etonogestrel, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about ethinyl estradiol/etonogestrel
- Ethinyl estradiol/etonogestrel Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 942 Reviews
- Drug class: contraceptives
- Ethinyl estradiol and etonogestrel vaginal ring
- Ethinyl estradiol and etonogestrel Vaginal (Advanced Reading)
Other brands: NuvaRing