Generic Name: doxorubicin liposomal (DOX-oh-ROO-bi-sin)
Brand Name: Doxil
Doxorubicin liposomal may cause severe and possibly life-threatening heart problems (eg, heart failure). These problems may occur during therapy or sometimes months to years after receiving doxorubicin liposomal. In some cases, heart problems are irreversible. The risk may be increased if you are using certain medicines that may affect heart function (eg, trastuzumab), or have a history of heart problems, radiation treatment to the chest area, or previous therapy with other anthracyclines (eg, epirubicin). The risk of developing heart problems varies depending on your dose and condition, although it can occur at any dose whether or not you are at risk. Notify your doctor right away if you develop cough; fast, slow, or irregular heartbeat; shortness of breath; sudden, unexplained weight gain; or swelling of the hands, ankles, or feet.
Serious and sometimes fatal infusion-related reactions have occurred with the use of doxorubicin liposomal. Most of these happened during the first treatment. Contact your doctor right away if you experience back pain, fever, chills, fainting, flushing, headache, fast heartbeat; severe dizziness, shortness of breath, wheezing, itching, blue or gray skin, swelling of the face, or tightness in the chest or throat.
Doxorubicin liposomal is used for:
Treating advanced ovarian cancer and AIDS-related Kaposi sarcoma in certain patients. It is also used with another medicine to treat a type of bone marrow cancer (multiple myeloma) in certain patients.
Doxorubicin liposomal is an antineoplastic antibiotic. It works by killing cancer cells.
Do NOT use doxorubicin liposomal if:
- you are allergic to any ingredient in doxorubicin liposomal or to similar medicines (eg, epirubicin)
- you have certain bone marrow problems (eg, low blood platelet levels, low red blood cell levels, low white blood cell levels)
Contact your doctor or health care provider right away if any of these apply to you.
Before using doxorubicin liposomal:
Some medical conditions may interact with doxorubicin liposomal. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have swelling or soreness of the mouth or tongue, blood vessel disease, an infection, or liver problems
- if you plan to receive any vaccines
- if you are older than 50 years old
- if you have a history of heart problems, mouth cancer, or radiation treatment (or are currently receiving radiation treatment), or if you have previously received doxorubicin liposomal or similar medicines (eg, epirubicin, daunorubicin)
- if you are taking medicines that may affect heart function (eg, calcium channel blockers, trastuzumab). Ask your doctor if you are unsure if any of your medicines may affect heart function
Some MEDICINES MAY INTERACT with doxorubicin liposomal. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Cyclophosphamide or mercaptopurine because the risk of their side effects may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if doxorubicin liposomal may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use doxorubicin liposomal:
Use doxorubicin liposomal as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Doxorubicin liposomal is given as an injection at your doctor's office, hospital, or clinic.
- Drinking extra fluids while you are taking doxorubicin liposomal is recommended. Check with your doctor for instructions.
- Your doctor may prescribe another medicine to lessen nausea and vomiting that can occur when taking doxorubicin liposomal. Discuss any questions with your doctor.
- If you spill doxorubicin liposomal on your skin, wash it off right away with soap and water.
- If you miss a dose of doxorubicin liposomal, contact your doctor right away.
Ask your health care provider any questions you may have about how to use doxorubicin liposomal.
Important safety information:
- Doxorubicin liposomal may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Doxorubicin liposomal may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Do not receive a live vaccine (eg, measles, mumps) while you are taking doxorubicin liposomal. Talk with your doctor before you receive any vaccine.
- Doxorubicin liposomal may cause the urine to turn red. This is harmless and usually goes away 1 to 2 days after receiving a dose of doxorubicin liposomal.
- Doxorubicin liposomal may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to doxorubicin liposomal. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Doxorubicin liposomal may cause cancer of the mouth. The risk is greater in those patients who take doxorubicin liposomal for more than a year. Your doctor will check your mouth while you use doxorubicin liposomal. Tell your doctor right away if you have mouth pain, sores, or ulcers.
- Lab tests, including liver function, complete blood cell counts, blood uric acid and electrolyte levels, and heart function, may be performed while you use doxorubicin liposomal. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Tell your doctor or dentist that you take doxorubicin liposomal before you receive any medical or dental care, emergency care, or surgery.
- Caution is advised when using doxorubicin liposomal in CHILDREN; they may be more sensitive to its effects.
- Doxorubicin liposomal may damage sperm. This may affect being able to father a child. This could be permanent. Men who have sex with a woman who may become pregnant must use effective birth control (eg, condoms) during treatment and for 6 months after treatment is stopped. Discuss any questions or concerns with your doctor.
- Periods may stop in women treated with this drug. This may not go back to normal. Women treated with this drug may go through menopause at a younger age than normal. Talk with your doctor.
- This drug may cause you to not be able to get pregnant. Talk with the doctor.
- PREGNANCY and BREAST-FEEDING: Doxorubicin liposomal has been shown to cause harm to the fetus. Avoid becoming pregnant while you are taking it and for 6 months after you stop taking it. If you are able to become pregnant, talk with your doctor about using an effective form of birth control. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using doxorubicin liposomal while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking doxorubicin liposomal.
Possible side effects of doxorubicin liposomal:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Back pain; constipation; diarrhea; hair loss; headache; indigestion; loss of appetite; nausea; tiredness; weakness; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); absence of menstrual cycle or menstrual changes; back pain; black, tarry stools; bluish skin or nails; bone pain; burning, numbness, or tingling; calf or leg pain, swelling, redness, or tenderness; chest pain; dizziness or light-headedness; fainting; fast, slow, or irregular heartbeat; flushing; headache; loose or bloody stools; night sweats; pain, redness, burning, stinging, swelling, or open sores at the injection site; rectal bleeding or irritation; redness or discharge of the eyes; redness, pain, swelling, peeling, tingling, or blistering of the palms of the hands and the soles of the feet; severe or persistent nausea or vomiting; shortness of breath; swelling of the hands, ankles, or feet; swelling or soreness of the mouth or tongue; symptoms of dehydration (eg, dry mouth or eyes, decreased urination, fast heartbeat, sluggishness, unusual thirst); symptoms of infection (eg, fever, chills, cough, sore throat, burning or painful urination); symptoms of bleeding (eg, throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop); unexplained or large weight gain or loss; unusual or severe tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of doxorubicin liposomal:
Doxorubicin liposomal is handled and stored by a health care provider. You will not store it at home. Keep doxorubicin liposomal out of the reach of children and away from pets.
- If you have any questions about doxorubicin liposomal, please talk with your doctor, pharmacist, or other health care provider.
- Doxorubicin liposomal is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take doxorubicin liposomal or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about doxorubicin liposomal. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to doxorubicin liposomal. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using doxorubicin liposomal.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Drug class: antibiotics/antineoplastics