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Kaposi's Sarcoma

Medically reviewed by Last updated on May 22, 2023.

What is Kaposi's Sarcoma?

Harvard Health Publishing

Kaposi's sarcoma is a type of cancer caused by the virus human herpes virus 8. The tumors appear as red or purple patches on the skin, mouth, lungs, liver, or gastrointestinal tract.

First described in 1872, Kaposi's sarcoma was considered rare and relatively harmless until the AIDS epidemic began. An aggressive form of the disease, AIDS-related Kaposi's sarcoma, occurs in people with severely weakened immune systems. It is now the most common type of Kaposi's sarcoma.

Kaposi's Sarcoma

The four types of Kaposi's sarcoma are

  • Classic Kaposi's sarcoma. This is a rare, slow growing skin tumor, usually affecting males of Italian or Eastern European Jewish ancestry. People with this form of the disease may develop non-Hodgkin lymphoma or another cancer before the skin lesions appear or later in life.

  • African Kaposi's sarcoma. Although extremely rare in the rest of the world, the disease occurs more often in young males in certain African countries. Usually it is a slow-growing tumor, but in some cases, it can be aggressive, invading bone and tissue under the skin.

  • Immunosuppressive-treatment-related Kaposi's sarcoma. People who are taking immunosuppressive medication after an organ transplant may develop this form of the disease. It sometimes improves if the medication is reduced or changed.

  • AIDS-related Kaposi's sarcoma. This disease affects people with HIV/AIDS. It usually appears as a rapidly progressing tumor affecting the skin, lymph nodes, gastrointestinal tract, lungs, liver, or spleen. Nearly all cases involve homosexual or bisexual men. The incidence of type of Kaposi's sarcoma is decreasing due to highly active retroviral therapy (HAART) for people with HIV/AIDS.


The first symptoms of Kaposi's sarcoma are usually red, purple, or brown patches, plaques, or nodules on the skin. (The abnormal growth of small blood vessels just below the skin gives the lesions their purplish hue.) They may look like bruises. In the classic, African, and immunosuppressive forms of the disease, the lesions usually grow slowly and develop over years. As the disease worsens, the legs may swell. In some cases, it will spread to other organs.

In the AIDS-related form, the cancer is much more aggressive, often growing to cover large areas and forming tumor-like masses. These lesions are usually soft and spongy at first, but they become hard and solid over time. The surface of the tumor may develop open ulcers that can become infected.

AIDS-related Kaposi's sarcoma is rarely confined to the skin. It often affects the mouth, lymph nodes, lungs, liver, spleen, and gastrointestinal tract. When the tumor involves the lungs, it often causes coughing, shortness of breath, and wheezing. The disease often progresses rapidly in the lungs. It may cause respiratory failure, which can be fatal.

When the disease involves the gastrointestinal tract, it rarely causes symptoms until it becomes very advanced. People may then develop symptoms of intestinal obstruction (nausea, vomiting, and abdominal pain) or bloody stools. If the lymph nodes become involved, severe swelling can occur, usually in the legs or face.


If your doctor suspects Kaposi's sarcoma, he or she will ask if you have HIV or another disease that may be suppressing your immune system. If you do not know if you have HIV, but you are at risk for it, your doctor will recommend an HIV test.

If you have HIV, your doctor will ask you several questions about your condition:

  • When were you diagnosed?

  • What medications are you currently taking? Have you taken other medications?

  • What other HIV-related illnesses (opportunistic infections) have you had?

  • What were the results of your most recent lab tests (such as CD4 count and viral load)?

Kaposi's sarcoma can be confirmed with a biopsy. In this test, a small piece of tissue is removed and examined under a microscope.

If you have Kaposi's sarcoma, your doctor will try to determine how far it has spread by examining you and asking you several questions:

  • Do you have a cough, or are you short of breath? (This could indicate that the cancer has reached the lungs.)

  • Do your legs swell up? (This suggests the cancer has reached lymph nodes.)

  • Do you experience nausea, vomiting, or abdominal pain? Do you have blood in your stool? (This suggests the cancer is affecting the gastrointestinal tract.)

Expected Duration

There is no cure for Kaposi's sarcoma. It is a lifelong condition. However, the symptoms will improve with treatment (such as HAART for people with HIV/AIDS.)


There is no way to prevent the milder forms of Kaposi's sarcoma (classic, African, and immunosuppression-related). The most effective way to avoid developing AIDS-related Kaposi's sarcoma is to prevent the spread of HIV. People who have HIV can decrease their risk of Kaposi's sarcoma by taking HAART.


The goals of treatment are to ease symptoms, shrink the tumor(s), and prevent the disease from getting worse. The treatment depends on the type of Kaposi's sarcoma, the size and location of the tumor(s), the extent of the disease, your CD4 count, and your overall health. Treatments include

  • topical therapy —applying a medicated gel directly to the skin lesion(s)

  • surgery — removing the cancer cells

  • cryotherapy — freezing the cancer cells to kill them

  • chemotherapy — using drugs to kill the cancer cells

  • radiation therapy — using radiation to kill the cancer cells

  • biological therapy — strengthening the body's immune system to better fight the cancer.

In people with AIDS, the lesions will improve with treatment of that condition. Typically, this involves taking antiretroviral medications to strengthen the immune system.

Treatment options

The following list of medications are in some way related to or used in the treatment of this condition.

View more treatment options

When To Call a Professional

See a doctor if you have skin changes that fit the description of Kaposi's sarcoma. If you have HIV and Kaposi's sarcoma, you will need immediate treatment; your doctor may need to change or add medications to treat the HIV.

If you have not been tested for HIV and you think you may have Kaposi's sarcoma, talk to your doctor right away. He or she will counsel you about risk factors for HIV and ask if you have symptoms suggestive of HIV/AIDS. These include

If you are at risk of HIV, your doctor will recommend a blood test to check for this virus. Early diagnosis of HIV is important, because the prognosis improves dramatically with treatment.


The outlook for Kaposi's sarcoma depends on the form of the disease you have. Milder forms are rare and develop slowly. People with classic Kaposi's sarcoma usually die of other causes or develop a second type of cancer. (About one-third of people with classic Kaposi's sarcoma develop another cancer.) Immunosuppression-related Kaposi's sarcoma often improves by changing the drug or its dose.

The most important factor in the prognosis for AIDS-related Kaposi's sarcoma is how well the immune system functions. Developing Kaposi's sarcoma suggests that the immune system is highly impaired. People with this disease usually die of a different HIV-related infection. People who take HAART have a better prognosis.

Additional Info

American Cancer Society (ACS)
1599 Clifton Road, NE
Atlanta, GA 30329-4251
Toll-Free: (800) 227-2345

Infectious Diseases Society of America
66 Canal Center Plaza, Suite 600
Alexandria, VA 22314
Phone:(703) 299-0200
Fax: (703) 299-0204

National Institute of Allergy and Infectious Diseases (NIAID)
Office of Communications & Public Liaison
5601 Fishers Lane, MSC 9806
Bethesda, MD 20892-9806
For deliveries, use Rockville, MD 20852
Phone: (301) 496-5717

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