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DOXYCYCLINE 100 MG CAPSULES

Active substance(s): DOXYCYCLINE HYCLATE / DOXYCYCLINE HYCLATE / DOXYCYCLINE HYCLATE

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Doctors may prescribe different doses to these
depending on the infection being treated. Check
with your doctor if you are not sure why you
have been prescribed this medicine. The label
on the pack will tell you what dose YOU should
take, how often and for how long to take it. If you
are still not sure, ask your doctor or pharmacist.

Doxycycline hyclate
PATIENT INFORMATION LEAFLET
Read all of this leaflet carefully before you
start taking this medicine because it
contains important information for you.
Keep this leaflet.You may need to read it again.
If you have any questions, ask your doctor,
pharmacist or nurse.
This medicine has been prescribed for you
only. Do not pass it on to others. It may harm
them, even if their signs of illness are the
same as yours.
If you get any side effects talk to your doctor,
pharmacist or nurse. This includes any
possible side effects not listed in this leaflet.
See section 4
What is in this leaflet:
1. What Doxycycline Capsules are and what
they are used for
2. What you need to know before you take
Doxycycline Capsules
3. How to take Doxycycline Capsules
4. Possible side effects
5. How to store Doxycycline Capsules
6. Contents of the pack and other information
1. What Doxycycline capsules are and what
they are used for
You may be given Doxycycline 100 mg Capsules
by your doctor to treat infections such as:
Chest, lung or nasal infections e.g.
bronchitis, pneumonia, sinusitis.
Urinary tract infections e.g. cystitis,
urethritis.
Acne which is a skin infection.
Eye infections.
Sexually transmitted diseases e.g.
gonorrhoea, syphilis, chlamydia.
Infections caused by parasites (associated
with louse or tick bites).
Malaria, when chloroquine is not effective.
Doxycycline 100 mg Capsules is also used to
prevent certain infections developing these are
scrub typhus, travellers' diarrhoea, malaria and
leptospirosis.
Your doctor may want you to take Doxycycline
100 mg Capsules to treat another infection not
listed above. You may also be prescribed an
additional medicine to take with Doxycycline
100 mg Capsules to treat your infection. If in
doubt talk to your doctor.
2. What you need to know before you take
Doxycycline Capsules
If the answer is YES to any of the questions
below DO NOT TAKE Doxycycline I00 mg
Capsules.
Have you been told you are allergic to
Doxycycline 100 mg Capsules or any other
tetracycline antibiotic?
Are you allergic to any of the other
ingredients in Doxycycline 100 mg
Capsules listed in section 6.1?
Are you pregnant or trying to become
pregnant?
Are you breast feeding?
Is this medicine prescribed for a child under
the age of 12 years?
Tetracyclines should not be used during tooth
development (during pregnancy, infancy and
children below 12 years old) as such use may
lead to per manent discolouration or
underdevelopment of the teeth (yellow-greybrown).
Warnings and precautions
Avoid exposure to strong sunlight while taking
this medicine. Your skin may be more sensitive
to sunburn than normal. If you get a skin rash,
itching, redness or severe sunburn when out in
strong sunlight or under ultraviolet light (e.g. on
a sun bed) stop taking the medicine and check
with your doctor.
Contains sucrose: If you have been told by
your doctor that you have an intolerance to
some sugars, contact your doctor before
taking this medicinal product.
If the answer is YES to any of the following
questions tell your doctor before you start
Doxycycline 100 mg capsules.
Are you likely to be exposed to strong
sunlight or ultraviolet light (e.g. on a sun
bed)?
Do you have liver problems?
Do you have myasthenia gravis (a disease
which causes unusual tiredness and
weakness of certain muscles, particularly
in the eyelid)?

Do you have porphyria (a rare disease of
blood pigments)?
Do you have (or have you ever had)
systemic lupus erythematosus? This
condition may be worsened by taking
Doxycycline 100 mg Capsules.

Take Doxycycline 100 mg Capsules with a full
glass of water.
It is best to take your capsules at the same
time(s) each day, when standing or while
sitting.
It is important not to lie down for at least
thirty minutes after taking Doxycycline 100
mg Capsules, so that the capsule can move
as swiftly as possible into the stomach and
prevent ir rita tion of the throa t or
oesophagus (canal taking food from the
mouth to the stomach).
If your stomach is upset, Doxycycline 100
mg Capsules can be taken with milk or a
meal.
Take the capsules for the full time of
treatment, even when you begin to feel
better. If you stop taking the capsules too
soon, the infection may return.

If you are suspected as having syphilis, your
doctor will continue to monitor you after your
treatment has stopped.
Can Doxycycline I00 mg Capsules be taken
with other medicines?
Some medicines may interfere with
Doxycycline 100 mg Capsules. You should tell
your doctor if you are taking any of the
medicines listed below. Also check with your
doctor if you are taking any other medicines:
Antacids (indigestion remedies), iron
preparations, oral zinc, sucralfate or
bismuth. If you take these at the same time
of day as Doxycycline it may stop this
medicine from working properly.
Warfarin or coumarins (used to prevent
blood clots). A reduced dose of these
medicines may be required when taking
doxycycline.
Oral contraceptives (birth control pills). Use
of birth control pills with tetracyclines may
impair the effect of the birth control pill and
increase the chance of unwanted
pregnancy.
Penicillin and rifampicin antibiotics
(used to treat infections). Doxycycline
may reduce the effect of these antibiotics.
Alcohol. Alcohol may reduce the effect of
Doxycycline.
Carbamazepine, phenytoin (medicines
used to control epilepsy) and barbiturates
(used to control epilepsy or as a sedative).
Ciclosporin (used to affect the body's
immune response).
Methoxyflurane (an anaesthetic). If you are
going to have a general anaesthetic for an
operation or dental surgery you must tell
your anaesthetist or dentist that you are
taking Doxycycline 100 mg Capsules.
Quinapril: used to treat high blood pressure
and heart failure
Sulfonylurea drugs used to treat diabetes
such as tolbutamide and glibenclamide

What to do if you take too many capsules?
An occasional extra dose taken by accident is
unlikely to be a problem, but if a large overdose
has been taken contact your doctor or your
nearest hospital Casualty Depar tment
immediately.
What to do if you miss a dose?
Do not worry. If you forget to take a capsule take
it as soon as you can. Take your next capsule at
the right time.
How quickly will the treatment start to work?
You should start to feel better within a few days.
If you have been given Doxycycline 100 mg
Capsules for acne it may be a few weeks before
you start to see an improvement.
What if you do not feel better?
If your infection gets worse or you do not start to
feel better within a few days (except for acne),
or a new infection develops, go back and see
your doctor.
4. Possible side effects
Like all medicines, Doxycycline Capsules can
cause side effects, although not everyone gets
them.
Stop taking Doxycycline capsules and seek
urgent medical attention if you experience any
of the following signs:
signs of a severe allergic reaction such as
sudden wheeziness, difficulty in breathing,
chest pain, fever, fast heart rate, sudden
swelling of the face, lips, throat, tongue,
hands or feet, skin rash or itching (especially
affecting the whole body).
signs of photosensitivity - you notice that
your skin is very sensitive to light (you may
get a skin rash, itching, redness or severe
sunburn when out in sunlight or after using a
sun bed).

Can you drive whilst taking this medicine?
There is no evidence to suggest that this
medicine will affect your ability to drive.
3. How to take Doxycycline Capsules
Usual Dose
(Respiratory, urinary
tract, ophthalmic and
other infections):

200mg on the first day
as a single dose or two
100mg doses, followed
by 100mg a day. For
severe infections your
doctor may increase the
dose to 200mg a day
Acne:
50mg daily for 6-12
weeks with food or
fluid.
Sexually transmitted 100mg twice daily for
diseases:
7-10 days.
Primary and
200mg twice daily
secondary syphilis:
for two weeks
Fevers associated
Single dose of 100mg
with louse or tick
or 200mg depending
bites:
on severity.
Treatment of malaria, 200mg daily for at
least 7 days.
when chloroquine is
not effective:
Prevention of malaria: 100mg daily from 1-2
days before travelling
until 4 weeks after
returning.
Single dose of
Prevention of scrub
200mg.
typhus:
100mg twice daily on
Prevention of
travellers' diarrhoea: the first day of travel,
followed by 100mg
daily throughout the
stay in the area. If you
are planning to take
these capsules for
more than 21 days,
please consult your
doctor.
200mg once each
Prevention of
week during the stay
leptospirosis:
in the area; 200mg on
completion of the trip.
If you are planning to
take these capsules
for more than 21
days, please consult
your doctor.

Contact your doctor immediately if you
experience any of the following symptoms:
Sore or swollen tongue and diarrhoea may
occur. A diarrhoeal disease (pseudomembranous colitis) has been reported which
may show as watery diarrhoea, fever and
cramps. Soreness and itching around the
back passage and/or genital areas, swelling
around the vagina, or thrush of the vagina or
mouth may also occur.
Doxycycline may alter the numbers of
certain types of blood cells. You may notice
that you are bruising easily, have more nose
bleeds or suffer from an increased number
of infections and sore throats. Porphyria has
been reported and may appear as sensitivity
of the skin to sunlight, inflammation of
nerves and stomach pains.
hepatitis (inflammation of the liver) and
jaundice (yellowing of the skin or white of
the eyes), liver failure and inflammation of
the pancreas
severe skin reactions such as erythema
multiforme (circular, irregular red patches),
Stevens-Johnson syndrome (rash with flushing,
fever, blisters or ulcers), toxic epidermal
necrolysis (reddening, peeling and swelling
that resembles burns).
If you suffer from systemic lupus erythematosus (SLE) you may notice that your condition gets worse.

Date 23/12/2016

Project
Market Trade Name

Doxycycline 100mg Capsules

Print Colours

Item Number

N/A

1

Market or Pack Owner

Crescent Pharma Ltd.

Dimensions

148mm x 410 - Leaflet

Non-Print

Scale

1:1

Technical Colours

Font Size

9pt

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Tell your doctor if you notice any of the
following effects or notice other side effects
not listed here:
Rare (may affect up to 1 in 1,000 people):
Pericarditis (inflammation affecting the heart)
Abnormal liver function tests.
Frequency not known (frequency cannot be
estimated from the available data):
Tinnitus (ringing or buzzing in the ears)
Aching muscles or joints
Headache
Indigestion
An increase in the amount of urea in the
blood. This is detected by a blood test
Pain in the abdomen
Feeling or being sick
Anorexia
Discolouration and under development of
teeth after long term use
Inflammation and/or ulcers of the gullet
causing stomach pain, loss of appetite,
feeling or being sick, heartburn, diarrhoea,
difficulty swallowing and a sore or painful
tongue or mouth
Bulging fontanelles (soft spot on head) of
infants
Increased pressure in the skull resulting in
severe headaches together with blurred
and/or double vision and blind spots.
These effects usually disappear upon
stopping the medicine; however, permanent
loss of vision has been reported
When taken for a long time, discolouration
of thyroid tissue has been reported. However,
this medicine does not impair thyroid function.
Low blood pressure
Loosening of the nail from the nail bed after
exposure to the sun.
Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide
more information on the safety of this medicine.
5. How to store Doxycycline Capsules
Keep this medicine out of the sight and reach of
children.
Store below 25�C in a dry place.
Do not use this medicine after the expiry date
which is stated on the pack. The expiry date
refers to the last day of that month. Do not
throw away any medicines via wastewater or
household waste. Ask your pharmacist how to
throw away medicines you no longer use.
These will help protect the environment.
6. Contents of the pack and other
information
What Doxycycline capsules contain
Each capsule contains 100mg of the active
ingredient Doxycycline (as Doxycycline
hyclate).
The other ingredients are sucrose and
maize starch microgranules, crospovidone,
polymethacrylate, talc, indigo carmine
(E132), yellow and black iron oxide (E172),
gelatin, titanium dioxide (E171).
What Doxycycline capsules look like and
contents of the pack
Doxycycline 100mg Capsules have opaque
green caps and bodies and are printed in white
with 100mg.
Doxycycline 100mg Capsules come in pack
sizes of 8, 10 and 50 capsules.
Marketing Authorisation Holder and
Manufacturer
Crescent Pharma Limited
3&4 Quidhampton Business Units
Polhampton Lane, Overton, Hampshire
RG25 3ED, UK.
Date of last revision: December 2016.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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