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Ramipril Patient Tips

Medically reviewed on Oct 29, 2017 by C. Fookes, BPharm.

How it works

  • Ramipril may be used in the treatment of high blood pressure or heart failure that occurs following a heart attack and works by inhibiting an enzyme called angiotensin-converting enzyme (ACE). This enzyme is involved in the production of angiotensin II, a powerful vasoconstrictor (narrows arteries), which also stimulates the release of the hormone aldosterone from the adrenal glands (aldosterone can increase blood pressure). By inhibiting this enzyme, ramipril opens up the arteries (vasodilates) and lowers blood pressure. This also reduces how hard the heart has to work to pump blood around the body, helping relieve symptoms of heart failure.
  • Ramipril belongs to a group of medicines known as angiotensin-converting enzyme (ACE) inhibitors.

Upsides

  • May be used for the treatment of high blood pressure.
  • Ramipril may also be used to treat heart failure that occurs in stable patients within the first few days following a heart attack.
  • In high blood pressure, ramipril reduces both lying down and standing blood pressure without a significant orthostatic effect (this is the drop sometimes seen when going from sitting to standing). However, dehydrated patients may be at higher risk of an orthostatic effect.
  • In people with heart failure, ramipril decreases heart size and increases how much blood the heart can pump out. It also increases exercise tolerance, without having much of an effect on heart rate. Ramipril use can decrease the severity of heart failure, rates of hospitalization and symptoms such as shortness of breath and tiredness. Beneficial effects remain apparent with continued dosing.
  • Effective alone or in combination with other treatments for high blood pressure.
  • Generic ramipril is available.

Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • A headache, dizziness, and fatigue are the most common side effects.
  • A dry cough which usually resolves on discontinuation of therapy. This side effect is common to all ACE inhibitors.
  • Occasionally, ramipril may cause excessive lowering of blood pressure but the risk is higher in those on diuretic therapy or who are sodium depleted or dehydrated.
  • Rarely may cause angioedema of the face, lips, tongue, throat, and extremities. May occur at any time during treatment. Immediate discontinuation is warranted if angioedema is affecting breathing.
  • Also rare is the development of blood disorders and kidney and liver failure.
  • May increase blood potassium levels, the risk is higher in people with diabetes, poor kidney function, and in people using potassium-sparing diuretics or taking potassium supplements.
  • May have less of a blood pressure-lowering effect in patients of African-American descent compared to those without this ethnicity. Also, the incidence of angioedema (a skin reaction associated with head and neck swelling) is higher in African-American patients.
  • May not be suitable for some people and can interact with a number of other medications (including NSAIDs, lithium) - consult your prescribing doctor before taking any other medications including those brought over the counter. A dosage reduction may be needed in people with kidney disease.
  • Ongoing monitoring of blood pressure, kidney function, and electrolyte levels is recommended.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

Bottom Line

Ramipril is used for the treatment of high blood pressure and also for heart failure that occurs immediately following a heart attack. Ramipril, as with other ACE inhibitors, may not be as effective in people of African-American descent.

Tips

  • Usually administered once daily; however, your doctor may decide to prescribe it to you twice daily if it appears the effects of ramipril are wearing off quickly. Ensure you are adequately hydrated before starting ramipril. If you are taking ramipril for high blood pressure, continue this medication even if you feel well. High blood pressure does not usually have symptoms.
  • Swallow whole, do not crush or chew. If necessary, open up the contents of the capsule and sprinkle on applesauce or mix with water or apple juice. May be taken with or without food.
  • Treatments that lower blood pressure, such as ramipril, should always be part of a comprehensive cardiovascular risk reduction plan (that also targets, if appropriate, cholesterol lowering, diabetes risk reduction, exercise, weight loss, and smoking cessation).
  • Report any signs of fever or a sore throat to your doctor who may carry out further tests to ensure it is not neutropenia (a decrease in white blood cells). Also report any signs or symptoms of angioedema (swelling of face or throat, difficulty breathing) immediately to your doctor.
  • Your doctor should monitor your blood pressure, kidney function and potassium levels regularly.
  • May cause a fall in blood pressure that may be noticed as light-headedness, especially when you rise from a sitting or lying down position. This usually goes away after a few days of therapy. However, if it persists, call your doctor and ask his advice, symptoms usually resolve with continued therapy. Ensure you do not become dehydrated. If you develop excessively low blood pressure, lie down and seek immediate medical attention.
  • Also call your doctor if you develop chest pain, a change in your heartbeat or muscle contraction or weakness.
  • Do not use salt substitutes or supplements containing potassium without first consulting your doctor.
  • Ensure you use adequate contraception or abstinence from sex to avoid pregnancy while taking ramipril. If you inadvertently become pregnant while taking ramipril, contact your healthcare provider immediately.
  • If you also have diabetes, you may need to monitor your blood sugar levels more closely during the first few weeks of ramipril therapy.
  • Limit your alcohol intake while taking ramipril because ramipril can further lower your blood pressure and increase the risk of side effects.

Response and Effectiveness

  • Peak concentrations of ramipril are reached within an hour of oral administration.
  • Blood pressure lowering effects are seen within an hour of oral administration with peak effects achieved by four to six hours. Blood pressure lowering effects are maintained for at least 24 hours, although in some patients these effects may diminish towards the end of the 24 hour period. It may take several weeks before optimal blood pressure lowering effects are achieved.
  • Abrupt withdrawal of ramipril has not resulted in an abrupt increase in blood pressure; however, as with most antihypertensive drugs, it is best to discontinue ramipril slowly.
  • Studies have shown that ramipril is as effective and well tolerated as enalapril.

References

  • Ramipril [Package Insert] Revised 06/2017. ZydusPharmaceuticals (USA) Inc. https://www.drugs.com/pro/ramipril.html
  • Ruddy, Michael & J. Mroczek, William. (1993). Comparison of Ramipril and Enalapril in Patients With Essential Hypertension. Pharmacotherapy. 13. 224-8. 10.1002/j.1875-9114.1993.tb02728.x.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use ramipril only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that this information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This drug information does not endorse drugs, diagnose patients or recommend therapy. It is an informational resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of this information. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Drugs.com. Revision Date: 2017-10-29 20:37:01

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