Paroxetine Patient Tips
Medically reviewed by C. Fookes, BPharm. Last updated on Aug 21, 2017.
How it works
- Paroxetine is a medicine that may be used in the treatment of depression and other mood disorders.
- Experts believe paroxetine's effects are due to its ability to rebalance chemicals in the brain, such as serotonin, that are imbalanced in people with anxiety, depression, and other disorders.
- Its activity against other neurotransmitters is much less potent than other antidepressants.
- Paroxetine belongs to a group of medicines called Selective Serotonin Reuptake Inhibitors (SSRIs). SSRIs are thought to work by preventing the reuptake of serotonin by nerves, leading to an increase in serotonin concentrations within the nerve synapse (space between two nerves).
- May be used in the treatment of moderate-to-severe depression (Major Depressive Disorder).
- May reduce feelings of anxiety in people with obsessive-compulsive disorder (OCD), panic disorder, or social or generalized anxiety disorder.
- Generic paroxetine is available.
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
- Drowsiness, headache, nausea, agitation, sweating, dry mouth, gastrointestinal disturbances, tremor, loss of energy, decreased appetite or abnormal ejaculation are some of the more commonly reported side effects.
- As with other antidepressants, paroxetine may increase the risk of suicidal thoughts or behavior particularly in young adults under the age of 24. Monitor for worsening mood.
- May impair your judgment and affect your ability to drive or operate machinery. Avoid alcohol.
- Interaction or overdosage may cause serotonin syndrome (symptoms include mental status changes [such as agitation, hallucinations, coma, delirium]), fast heart rate, dizziness, flushing, muscle tremor or rigidity and stomach symptoms (including nausea, vomiting, and diarrhea). Another serious syndrome called Neuroleptic Malignant Syndrome has also been reported; symptoms include high body temperature, muscle rigidity, and mental disturbances; discontinue immediately and seek urgent medical advice.
- May increase the risk of bleeding, especially if used with other drugs that also increase bleeding risk.
- May precipitate a manic episode in people with undiagnosed bipolar disorder.
- May cause lowering of total body sodium (called hyponatremia); elderly people or people taking diuretics or already dehydrated may be more at risk.
- May cause a discontinuation syndrome if abruptly stopped; symptoms include irritability, low mood, dizziness, electric shock sensations, headache, and confusion.
- Rarely causes seizures.
Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.
- Swallow paroxetine tablets whole, do not crush or chew. May be taken with or without food.
- Be alert for changes in behavior including agitation, depressed mood, and suicide-related events and seek medical advice if changes are apparent.
- Do not drive or operate machinery until the full effects of paroxetine are known as it may impair your judgment and affect your ability to drive or operate machinery.
- Report any problems with bleeding or bruising to your doctor, also report any unexplained skin changes (such as blisters or rashes), problems with urination, eye pain or swelling and vision changes to your doctor.
- Children and adolescents should have their height and weight monitored during treatment.
- Do not stop suddenly as withdrawal symptoms may occur; taper off slowly on a doctor's advice.
- Seek medical advice if a rash develops while taking paroxetine. Discontinue if a severe allergic reaction to paroxetine occurs.
- Seek urgent medical advice if symptoms consistent with serotonin syndrome (such as agitation, hallucinations, fast heart rate, dizziness, flushing, nausea, diarrhea) or Neuroleptic Malignant Syndrome (including a high body temperature, muscle rigidity, or mental disturbances) develop.
Response and Effectiveness
- Peak plasma concentrations of paroxetine are reached in approximately five hours. Some reduction in the symptoms of depression or anxiety may be noticed within a few weeks; however, it may take up to six to eight weeks for the full effects of paroxetine to develop.
Paroxetine [Package Insert]. Revised 07/2017. International Laboratories, LLC https://www.drugs.com/pro/paroxetine.html
More about paroxetine
- Paroxetine Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 1014 Reviews
- Drug class: selective serotonin reuptake inhibitors
- FDA Alerts (8)
- Paroxetine Controlled-Release Tablets
- Paroxetine Capsules
- Paroxetine Suspension
- Paroxetine Tablets
- Paroxetine (Advanced Reading)
Related treatment guides
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use paroxetine only for the indication prescribed.
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