Skip to main content

Paroxetine: 7 things you should know

Medically reviewed by Carmen Fookes, BPharm. Last updated on Sep 9, 2022.

1. How it works

  • Paroxetine is a medicine that may be used in the treatment of depression and other mood disorders.
  • Experts are unsure exactly how paroxetine works, although historically it was believed that paroxetine’s effects were due to its ability to rebalance chemicals in the brain, such as serotonin, that were thought to be imbalanced in people with mood disorders. Studies confirm that paroxetine is still effective for treating mood disorders, such as depression, even though the way it works is unknown.
  • Its activity against other neurotransmitters is much less potent than other antidepressants.
  • Paroxetine belongs to a group of medicines called Selective Serotonin Reuptake Inhibitors (SSRIs).

2. Upsides

  • May be used in the treatment of moderate-to-severe depression (Major Depressive Disorder).
  • May reduce feelings of anxiety in people with obsessive-compulsive disorder (OCD), panic disorder, or social or generalized anxiety disorder.
  • Generic paroxetine is available.

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Drowsiness, headache, nausea, agitation, sweating, dry mouth, gastrointestinal disturbances, tremor, loss of energy, decreased appetite or abnormal ejaculation are some of the more commonly reported side effects.
  • As with other antidepressants, paroxetine may increase the risk of suicidal thoughts or behavior particularly in young adults under the age of 24. Monitor for worsening mood.
  • May impair your judgment and affect your ability to drive or operate machinery. Avoid alcohol.
  • Interaction or overdosage may cause serotonin syndrome (symptoms include mental status changes [such as agitation, hallucinations, coma, delirium]), fast heart rate, dizziness, flushing, muscle tremor or rigidity and stomach symptoms (including nausea, vomiting, and diarrhea). Another serious syndrome called Neuroleptic Malignant Syndrome has also been reported; symptoms include high body temperature, muscle rigidity, and mental disturbances; discontinue immediately and seek urgent medical advice.
  • May increase the risk of bleeding, especially if used with other drugs that also increase bleeding risk.
  • May precipitate a manic episode in people with undiagnosed bipolar disorder.
  • May cause lowering of total body sodium (called hyponatremia); elderly people or people taking diuretics or already dehydrated may be more at risk.
  • May cause a discontinuation syndrome if abruptly stopped; symptoms include irritability, low mood, dizziness, electric shock sensations, headache, and confusion.
  • Rarely causes seizures.
  • Infants exposed to paroxetine during the first trimester of pregnancy have an increased risk of birth defects, particularly cardiovascular birth defects. If a woman becomes pregnant during treatment with paroxetine she should be advised of the potential risks to the fetus and offered the choice of discontinuing treatment with paroxetine, switching to another antidepressant, or continuing with paroxetine if the benefits outweigh the risks. Only initiate paroxetine in women who are already pregnant or intending to become pregnant if other treatment options are not suitable. Paroxetine is excreted into breastmilk and the infant should be monitored for adverse effects and breastfeeding discontinued if any are apparent.

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

  • Paroxetine may be used in the treatment of depression or anxiety disorders. Common side effects include a headache and nausea. Taking paroxetine with other medications such as tramadol that also release serotonin or overdosing on paroxetine may cause serotonin syndrome (symptoms include mental status changes [such as agitation, hallucinations, coma, delirium]), fast heart rate, or dizziness).

5. Tips

  • Swallow paroxetine tablets whole, do not crush or chew. May be taken with or without food.
  • Be alert for changes in behavior including agitation, depressed mood, and suicide-related events and seek medical advice if changes are apparent.
  • Do not drive or operate machinery until the full effects of paroxetine are known as it may impair your judgment and affect your ability to drive or operate machinery.
  • Report any problems with bleeding or bruising to your doctor, also report any unexplained skin changes (such as blisters or rashes), problems with urination, eye pain or swelling and vision changes to your doctor.
  • Children and adolescents should have their height and weight monitored during treatment.
  • Do not stop suddenly as withdrawal symptoms may occur; taper off slowly on a doctor's advice.
  • Seek medical advice if a rash develops while taking paroxetine. Discontinue if a severe allergic reaction to paroxetine occurs.
  • Seek urgent medical advice if symptoms consistent with serotonin syndrome (such as agitation, hallucinations, fast heart rate, dizziness, flushing, nausea, diarrhea) or Neuroleptic Malignant Syndrome (including a high body temperature, muscle rigidity, or mental disturbances) develop.
  • Tell your doctor if you are pregnant, intending to become pregnant, or are breastfeeding because paroxetine may not be suitable for you.

6. Response and effectiveness

  • Peak plasma concentrations of paroxetine are reached in approximately five hours. Some reduction in the symptoms of depression or anxiety may be noticed within a few weeks; however, it may take up to six to eight weeks for the full effects of paroxetine to develop.

7. Interactions

Medicines that interact with paroxetine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with paroxetine. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with paroxetine include:

  • anticoagulants (blood thinners), such as warfarin, or other drugs that have blood thinning effects such as aspirin or NSAIDs
  • anticonvulsants, such as phenytoin, phenobarbital, or primidone
  • antipsychotics (such as butyrophenones, phenothiazines, or thioxanthenes) and atypical antipsychotics (eg, olanzapine, quetiapine, ziprasidone)
  • any medication that may cause drowsiness, such as benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as codeine, morphine)
  • diuretics, such as furosemide
  • medications that may affect the heartbeat, such as amiodarone, encainide, or flecainide
  • pimozide and other drugs that are metabolized by the same enzymes such as astemizole, cimetidine, cisapride, cyclosporine, ketoconazole, terfenadine, or triazolam
  • other antidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), and SSRIs (eg, fluoxetine, sertraline)
  • other medications that affect serotonin, such as amphetamines, fentanyl, lithium, tramadol, triptans (eg, almotriptan, eletriptan, or sumatriptan), or St. John's Wort
  • thioridazine
  • others, such as HIV medications (fosamprenavir, ritonavir), procyclidine, or theophylline.

Avoid drinking alcohol or taking illegal or recreational drugs while taking paroxetine.

Note that this list is not all-inclusive and includes only common medications that may interact with paroxetine. You should refer to the prescribing information for paroxetine for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use paroxetine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2023 Revision date: September 9, 2022.