Skip to main content

Buprenex: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on March 28, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Buprenex is a potent analgesic that should be only used to treat moderate to severe pain under strict conditions when other analgesics have proved inadequate. Sedation is the main side effect and it also carries a risk for life-threatening respiratory depression, addiction, abuse, and misuse that may lead to overdose and death.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Buprenex may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Buprenex. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with Buprenex include:

Any medication that releases serotonin (such as amitriptyline, tramadol, or St. John's Wort) may interact with Buprenex and cause serotonin syndrome, a potentially fatal condition that occurs when levels of serotonin get too high in your body. Symptoms can range from mild (shivering and diarrhea) to severe (muscle rigidity, fever, and seizures).

Avoid drinking alcohol or taking illegal or recreational drugs while taking Buprenex.

Note that this list is not all-inclusive and includes only common medications that may interact with Buprenex. You should refer to the prescribing information for Buprenex for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Buprenex only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: March 28, 2023.