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Ziv-aflibercept Side Effects

Medically reviewed by Last updated on Sep 14, 2023.

Applies to ziv-aflibercept: intravenous solution.

Serious side effects of Ziv-aflibercept

Along with its needed effects, ziv-aflibercept may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ziv-aflibercept:

More common

Less common


Incidence not known

Other side effects of Ziv-aflibercept

Some side effects of ziv-aflibercept may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to ziv-aflibercept: intravenous solution.


Very common (10% or more): Hypertension (41%)

Common (1% to 10%): Arterial thromboembolic events (ATE) (e.g., transient ischemic attack, cerebrovascular accident, angina pectoris)

Postmarketing reports: Cardiac failure, ejection fraction decreased[Ref]


Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (11%)

Common (1% to 10%): Skin hyperpigmentation[Ref]


Very common (10% or more): Diarrhea (69%), stomatitis (50%), abdominal pain (27%), abdominal pain upper (11%)

Common (1% to 10%): Fistulas (anal, enterovesical, enterocutaneous, colovaginal, intestinal sites), dehydration, oropharyngeal pain, hemorrhoids, rectal hemorrhage, proctalgia

Uncommon (0.1% to 1%): GI hemorrhage, toothache[Ref]


Common (1% to 10%): Urinary tract infection


Very common (10% or more): Leukopenia (78%), neutropenia (67%), thrombocytopenia (35%), hemorrhage (38%)[Ref]


Uncommon (0.1% to 1%): Hypersensitivity[Ref]


Very common (10% or more): Infections (46%)

Common (1% to 10%): Immunogenicity[Ref]


Very common (10% or more): Anorexia (32%), weight loss (32%)

Postmarketing reports: Osteonecrosis of the jaw[Ref]

Nervous system

Very common (10% or more): Headache (22%)

Uncommon (0.1% to 1%): Reversible posterior leukoencephalopathy syndrome (RPLS)[Ref]


Very common (10% or more): Fatigue (48%), dysphonia (25%), asthenia (18%)

Uncommon (0.1% to 1%): Compromised wound healing[Ref]


Very common (10% or more): Proteinuria (62%), serum creatinine increased (23%)[Ref]


Very common (10% or more): Epistaxis (28%), dyspnea (12%)

Common (1% to 10%): Rhinorrhea, nasopharyngitis[Ref]


Very common (10% or more): AST increased (62%), ALT increased (50%)[Ref]


1. (2012) "Product Information. Zaltrap (ziv-aflibercept)." sanofi-aventis

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.