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Ziv-Aflibercept Dosage

Medically reviewed by Drugs.com. Last updated on Apr 15, 2024.

Applies to the following strengths: 25 mg/mL

Usual Adult Dose for Colorectal Cancer

4 mg/kg IV over 1 hour every 2 weeks; administer this drug prior to any component of the FOLFIRI regimen on the day of treatment


Use: This drug in combination with 5-fluorouracil, leucovorin, irinotecan-(FOLFIRI), is indicated for patients with metastatic colorectal cancer (mCRC) that is resistant to or has progressed following an oxaliplatin-containing regimen

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Discontinue this drug for:


Temporarily suspend this drug for:

Precautions

US BOXED WARNINGS:
HEMORRHAGE:

Recommendations:
GI PERFORATION:
Recommendation:
COMPROMISED WOUND HEALING:
Recommendations:

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

PVC containing DEHP or DEHP free PVC containing trioctyl-trimellitate (TOTM) or polypropylene or polyethylene lined PVC or polyurethane

Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.