Xylocaine-MPF Side Effects

Generic name: lidocaine

Medically reviewed by Drugs.com. Last updated on Jul 17, 2023.

Note: This document provides detailed information about Xylocaine-MPF Side Effects associated with lidocaine. Some dosage forms listed on this page may not apply specifically to the brand name Xylocaine-MPF.

Applies to lidocaine: injection solution.

Other dosage forms:

• intradermal powder

Precautions

It is very important that your doctor check you or your child's progress closely while you are receiving this medicine to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause a rare, but serious blood problem called methemoglobinemia. The risk may be increased in children younger than 6 months of age, elderly patients, or patients with certain inborn defects. It is more likely to occur in patients receiving too much of the medicine, but can also occur with small amounts. Check with your doctor right away if you or your child has the following symptoms after receiving this medicine: pale, gray, or blue-colored skin, lips, or nails, confusion, headache, lightheadedness, fast heartbeat, or unusual tiredness or weakness.

If you receive this medicine into your lower back (epidural), you may experience temporary loss of sensation and movement, usually in the lower half of your body. Talk with your doctor if you have concerns.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Xylocaine-MPF

Along with its needed effects, lidocaine (the active ingredient contained in Xylocaine-MPF) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lidocaine:

Other side effects of Xylocaine-MPF

Some side effects of lidocaine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to lidocaine: compounding powder, injectable solution, intravenous solution.

General adverse events

Adverse reactions following administration of this drug are similar in nature to those observed with other amide local anesthetic agents. The most serious adverse reactions tend to be systemic in nature. In general, these adverse reactions are dose-related and may result from high plasma levels caused by excessive dosage, rapid absorption, or inadvertent intravascular injection, or may result from a hypersensitivity, idiosyncrasy, or diminished tolerance on the part of the patient.^[Ref]

Cardiovascular

• Frequency not reported: Bradycardia, hypotension, cardiovascular collapse, cardiac arrest, circulatory collapse, hypertension, arrhythmia, maternal hypotension, shock, tachycardia, ventricular fibrillation, heart block, myocardial depression, peripheral vasodilation^[Ref]

Nervous system

• Frequency not reported: Lightheadedness, headache, dizziness, drowsiness, cold/numbness, tremor, convulsions, unconsciousness, positional headache, peripheral nerve symptoms, spinal cord deficit, paresthesia, speech slurred, arachnoiditis, peripheral nerve injury, coma, paralysis of the lower extremities, cauda equina syndrome, Horner's syndrome, hemiparesis, circumoral paresthesia, nystagmus^[Ref]

Gastrointestinal

• Frequency not reported: Vomiting, nausea, bowel control loss, swallowing difficult, numbness of tongue^[Ref]

Psychiatric

• Frequency not reported: Nervousness, apprehension, euphoria, confusion, agitation, disorientation, psychosis, restlessness, excitement^[Ref]

Hematologic

• Frequency not reported: Methemoglobinemia^[Ref]

Dermatologic

• Frequency not reported: Urticaria, cutaneous lesion, dermatitis, rash, angioedema, face edema^[Ref]

Genitourinary

• Frequency not reported: Bladder control loss, sexual function loss, perineal sensation loss, urinary retention^[Ref]

Immunologic

• Frequency not reported: Allergic reaction, anaphylaxis/anaphylactoid reaction^[Ref]

Local

• Frequency not reported: Persistent anesthesia^[Ref]

Metabolic

• Frequency not reported: Hypoglycemia^[Ref]

Musculoskeletal

• Frequency not reported: Twitching, backache, leg pain, buttock pain^[Ref]

Ocular

• Frequency not reported: Blurred/doubled vision, diplopia, transient amaurosis, bilateral amaurosis^[Ref]

Other

• Frequency not reported: Tinnitus, feeling hot, edema, shiver, total spinal block, hyperacusis, weakness, sphincter control loss^[Ref]

Respiratory

• Frequency not reported: Respiratory depression, respiratory arrest, dyspnea, bronchospasm, hypoventilation, apnea, respiratory inadequacy, respiratory failure, yawning^[Ref]

See also:

Further information

Xylocaine-MPF side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer