Vitrakvi Side Effects

Generic name: larotrectinib

Medically reviewed by Drugs.com. Last updated on Jun 26, 2024.

Note: This document provides detailed information about Vitrakvi.

Applies to larotrectinib: oral capsule, oral solution Side Effects associated with larotrectinib. Some dosage forms listed on this page may not apply specifically to the brand name Vitrakvi.

Applies to larotrectinib: oral capsule, oral solution.

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. It may also cause birth defects if the father is using it when his sexual partner becomes pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Female patients should use effective birth control during treatment with this medicine and for at least 1 week after the last dose. Male patients who have female partners should use effective birth control during treatment with this medicine and for 1 week after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

Check with your doctor right away if you have confusion, dizziness, memory loss, mood or mental changes, or sleep problems. These may be symptoms of a nervous system problem.

This medicine may make you dizzy, confused, or less alert than you are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

This medicine may increase your risk of bone fractures. Check with your doctor right away if you have bone pain, changes in movement, or any bone problems. Ask your doctor about ways to keep your bones strong to help prevent fractures.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

If you plan to have children, talk with your doctor before using this medicine. Some women using this medicine have become infertile (unable to have children).

Cancer medicines can cause diarrhea, nausea, vomiting, or stomach pain in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these unwanted effects.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Serious side effects of Vitrakvi

Along with its needed effects, larotrectinib (the active ingredient contained in Vitrakvi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking larotrectinib:

Other side effects of Vitrakvi

Some side effects of larotrectinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to larotrectinib: oral capsule, oral solution.

General adverse events

The most common adverse reactions (20% or greater) were fatigue, nausea, dizziness, vomiting, anemia, increased AST, cough, increased ALT, constipation, and diarrhea.^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (14%), myalgia (14%), muscular weakness (13%), back pain (12%), pain in extremity (12%)^[Ref]

Metabolic

• Very common (10% or more): Peripheral edema (15%), increased weight (15%), decreased appetite (13%)^[Ref]

Psychiatric

• Common (1% to 10%): Delirium, memory impairment^[Ref]

Hepatic

• Very common (10% or more): Hepatotoxicity (45%), Increased ALT (45%), increased AST (45%), increased alkaline phosphatase (30%)^[Ref]

Respiratory

• Very common (10% or more): Cough (26%), dyspnea (18%), nasal congestion (10%)^[Ref]

Other

• Very common (10% or more): Fatigue (37%), pyrexia (18%), fall (10%)^[Ref]

Hematologic

• Very common (10% or more): Anemia (42%), hypoalbuminemia (35%), neutropenia (23%)^[Ref]

Nervous system

• Very common (10% or more): Neurotoxicity (53%), dizziness (28%), headache (14%)
• Common (1% to 10%): Dysarthria, gait disturbance, tremor, paresthesia
• Uncommon (0.1% to 1%): Grade 4 encephalopathy^[Ref]

Cardiovascular

• Very common (10% or more): Hypertension (11%)^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (29%), vomiting (26%), constipation (23%), diarrhea (22%), abdominal pain (13%)^[Ref]

See also:

Frequently asked questions

• What type of drug is Vitrakvi (larotrectinib)?

Further information

Vitrakvi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer