Vitrakvi Side Effects

Generic name: larotrectinib

Medically reviewed by Drugs.com. Last updated on Sep 15, 2022.

Note: This document contains side effect information about larotrectinib. Some dosage forms listed on this page may not apply to the brand name Vitrakvi.

Applies to larotrectinib: oral capsule, oral solution.

Serious side effects of Vitrakvi

Along with its needed effects, larotrectinib (the active ingredient contained in Vitrakvi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking larotrectinib:

More common

Being forgetful
black, tarry, stools
bladder pain
bloating or swelling of the face, arms, hands, lower legs, or feet
bloody or cloudy urine
blurred vision
chest tightness
chills
confusion as to time, place, or person
cough
difficult, burning, or painful urination
discouragement
dizziness
falls
fear, nervousness
feeling sad or empty
fever
frequent urge to urinate
headache
holding false beliefs that cannot be changed by fact
irritability
lack of appetite
loss of interest or pleasure
loss of memory
lower back or side pain
nervousness
painful or difficult urination
pale skin
pounding in the ears
problems with memory
problems with speech or speaking
rapid weight gain
seeing, hearing, or feeling things that are not there
sleepiness or unusual drowsiness
slow or fast heartbeat
sore throat
tingling of the hands or feet
trouble breathing
trouble concentrating
trouble sleeping
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual excitement, nervousness, or restlessness
unusual tiredness or weakness
unusual weight gain or loss

Less common

Chest pain or discomfort
confusion
decreased urination
diarrhea
dry mouth
fainting
heartburn
increase in heart rate
increased thirst
indigestion
irregular heartbeat
itching, pain, redness, swelling, tenderness, or warmth on the skin
lightheadedness
loss of consciousness
muscle pain, cramps, or weakness
nausea
problems with movement or walking
rapid, shallow breathing
seizures
severe stomach pain, cramping, or burning
sunken eyes
swelling of the face, ankles, or hands
vomiting
vomiting of material that looks like coffee grounds, severe and continuing
wrinkled skin
yellow skin or eyes

Other side effects of Vitrakvi

Some side effects of larotrectinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain
constipation
decreased appetite
difficulty in moving
increased weight
joint pain or swelling
muscle stiffness
pain in the arms or legs
stuffy nose

Less common

Lack or loss of strength

For Healthcare Professionals

Applies to larotrectinib: oral capsule, oral solution.

Hematologic

Very common (10% or more): Anemia (42%), hypoalbuminemia (35%), neutropenia (23%)^[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (14%), myalgia (14%), muscular weakness (13%), back pain (12%), pain in extremity (12%)^[Ref]

Metabolic

Very common (10% or more): Peripheral edema (15%), increased weight (15%), decreased appetite (13%)^[Ref]

Psychiatric

Common (1% to 10%): Delirium, memory impairment^[Ref]

Hepatic

Very common (10% or more): Hepatotoxicity (45%), Increased ALT (45%), increased AST (45%), increased alkaline phosphatase (30%)^[Ref]

Respiratory

Very common (10% or more): Cough (26%), dyspnea (18%), nasal congestion (10%)^[Ref]

Other

Very common (10% or more): Fatigue (37%), pyrexia (18%), fall (10%)^[Ref]

General

The most common adverse reactions (20% or greater) were fatigue, nausea, dizziness, vomiting, anemia, increased AST, cough, increased ALT, constipation, and diarrhea.^[Ref]