Vitamin B6 Side Effects
Generic Name: pyridoxine
Note: This document contains side effect information about pyridoxine. Some of the dosage forms listed on this page may not apply to the brand name Vitamin B6.
For the Consumer
Applies to pyridoxine: capsule, injectable, solution, tablet, tablet enteric coated, tablet extended release
Along with its needed effects, pyridoxine (the active ingredient contained in Vitamin B6) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking pyridoxine:With large doses
- numbness of hands or feet
For Healthcare Professionals
Applies to pyridoxine: compounding powder, injectable solution, oral capsule, oral tablet
The profound sensory loss following treatment with high doses of parenteral pyridoxine (the active ingredient contained in Vitamin B6) may not be reversible.[Ref]
Nervous system side effects have included sensory neuropathy with axonal degeneration. The adverse neurologic side effects have been reported following a single large dose (10 g) administered intravenously. It may rarely occur following chronic administration of lower doses. Peripheral sensory neuropathy has also been reported.[Ref]
Hypersensitivity side effects have been reported rarely.[Ref]
Dermatologic side effects have included allergic contact dermatitis. Photosensitivity has been confirmed in a female patient taking pyridoxine (the active ingredient contained in Vitamin B6) 100 mg orally daily.[Ref]
1. Albin RL, Albers JW "Long-term follow-up of pyridoxine-induced acute sensory neuropathy- neuronopathy." Neurology 40 (1990): 1319
2. "Multum Information Services, Inc. Expert Review Panel"
3. Morimoto K, Kawada A, Hiruma M, Ishibashi A "Photosensitivity from pyridoxine hydrochloride (vitamin b-6)." J Am Acad Dermatol 35 (1996): 304-5
4. Camarasa JG, Serra-Baldrich E, Lluch M "Contact allergy to vitamin B6." Contact Dermatitis 23 (1990): 115
Some side effects of Vitamin B6 may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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- Drug class: vitamins
Other brands: Aminoxin
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