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Vitamin B6 Side Effects

Generic name: pyridoxine

Medically reviewed by Last updated on Jan 20, 2024.

Note: This document contains side effect information about pyridoxine. Some dosage forms listed on this page may not apply to the brand name Vitamin B6.

Applies to pyridoxine: capsule, powder, solution, tablet, tablet extended release.

Serious side effects of Vitamin B6

Along with its needed effects, pyridoxine (the active ingredient contained in Vitamin B6) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking pyridoxine:

With large doses

For Healthcare Professionals

Applies to pyridoxine: compounding powder, injectable solution, oral capsule, oral tablet.

Nervous system

The profound sensory loss following treatment with high doses of parenteral pyridoxine (the active ingredient contained in Vitamin B6) may not be reversible.[Ref]

Frequency not reported: Paresthesia, somnolence[Ref]


Frequency not reported: Low serum folic acid levels[Ref]


1. Product Information. Pyridoxine Hydrochloride (pyridoxine). APP (Abraxis Pharmaceutical Products). 2018.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.