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Vagistat-1 Side Effects

Generic name: tioconazole topical

Medically reviewed by Drugs.com. Last updated on Jul 7, 2023.

Note: This document contains side effect information about tioconazole topical. Some dosage forms listed on this page may not apply to the brand name Vagistat-1.

Applies to tioconazole topical: intravaginal ointment.

Side effects include:

Vulvovaginal burning, irritation, vaginitis, pruritus, headache.

For Healthcare Professionals

Applies to tioconazole topical: vaginal ointment w/applicator.

Other

Topical solution:

-Common (1% to 10%): Peripheral edema

-Frequency not reported: Pain[Ref]

Dermatologic

Topical solution:

-Uncommon (0.1% to 1%): Rash, dermatitis

-Frequency not reported: Bullous eruption, contact dermatitis, dry skin, nail disorder (including nail discoloration, periungual inflammation, nail pain), pruritus, skin irritation, skin exfoliation, urticaria[Ref]

Local

Topical solution: Local irritation (including local allergic reactions) usually occurred during the first week of therapy and was transient and mild.[Ref]

Topical solution:

-Frequency not reported: Local irritation (including local allergic reactions)

Vaginal ointment:

-Frequency not reported: Burning, itching, pain, irritation, dryness[Ref]

Genitourinary

Vaginal ointment:

-Frequency not reported: Increased vaginal burning, increased vaginal itching, increased vaginal irritation, vaginal swelling/redness, difficulty/burning on urination[Ref]

Gastrointestinal

Vaginal ointment:

-Frequency not reported: Abdominal pain/cramping[Ref]

Hypersensitivity

Topical solution:

-Frequency not reported: Allergic reaction

Other formulations than the dermatological preparation:

-Frequency not reported: Anaphylactoid reactions[Ref]

Nervous system

Topical solution:

-Frequency not reported: Paresthesia

Vaginal ointment:

-Frequency not reported: Headache[Ref]

Ocular

Topical solution:

-Frequency not reported: Periorbital edema[Ref]

Respiratory

Vaginal ointment:

-Frequency not reported: Upper respiratory infection[Ref]

Frequently asked questions

References

1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Stein GE, Gurwith D, Mummaw N, Gurwith M. Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis. Antimicrob Agents Chemother. 1986;29:969-71.

3. Clissold SP, Heel RC. Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses. Drugs. 1986;31:29-51.

4. Product Information. Vagistat-1 (tioconazole topical). Bristol-Myers Squibb. 2022.

5. Onayemi O, Aldridge RD, Shaw S. Allergic contact dermatitis from tioconazole. A report of 2 cases. Contact Dermatitis. 1992;26:193-4.

6. Stubb S, Heikkila H, Reitamo S, Forstrom L. Contact allergy to tioconazole. Contact Dermatitis. 1992;26:155-8.

7. Izu R, Aguirre A, Gonzalez M, Diaz-Perez JL. Contact dermatitis from tioconazole with cross-sensitivity to other imidazoles. Contact Dermatitis. 1992;26:130-1.

8. Jones SK, Kennedy CT. Contact dermatitis from tioconazole. Contact Dermatitis. 1990;22:122-3.

9. Gibson G, Buckley A, Murphy GM. Allergic contact dermatitis from tioconazole without cross- sensitivity to other imidazoles. Contact Dermatitis. 1994;30:308.

10. Quirino AP, Barros MA. Contact dermatitis from tioconazole. Contact Dermatitis. 1994;30:240-1.

11. Piletta P, Pasche-Koo F, Saurat JH. Contact dermatitis from tioconazole mimicking "one hand two feet syndrome". Contact Dermatitis. 1993;28:308.

12. Marren P, Powell S. Contact sensitivity to tioconazole and other imidazoles. Contact Dermatitis. 1992;27:129-30.

13. Brunelli D, Vincenzi C, Morelli R, Tosti A. Contact dermatitis from tioconazole. Contact Dermatitis. 1992;27:120.

14. Faria A, Goncalo S, Goncalo M, Freitas C, Baptista PP. Allergic contact dermatitis from tioconazole. Contact Dermatitis. 1996;35:250-2.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.