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Unoprostone ophthalmic Side Effects

In Summary

Commonly reported side effects of unoprostone ophthalmic include: xerophthalmia, burning sensation of eyes, eye pruritus, conjunctival injection, stinging of eyes, and increased eyelash length. Other side effects include: visual disturbance, eyelid disease, abnormal lacrimation, foreign body sensation, and decreased eyelash length. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to unoprostone ophthalmic: ophthalmic solution

As well as its needed effects, unoprostone ophthalmic may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking unoprostone ophthalmic, check with your doctor or nurse as soon as possible:

Less common:
  • Blood in the whites of the eyes
  • blurred vision or eye pain
  • eye irritation or redness
Rare:
  • Blindness
  • color blindness
  • decreased vision or other changes in vision

Severity: Minor

Some unoprostone ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abnormal tearing of eyes
  • burning or stinging of eyes
  • chills
  • cough
  • diarrhea
  • double vision
  • dry eyes
  • fever
  • general feeling of discomfort or illness
  • headache
  • itching of eyes
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Less common or rare:
  • Discharge from eye
  • inflammation of the eye
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • sensitivity to light

Severity: Minor

Some unoprostone ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Feeling of having something in the eye
  • increased or decreased length of eyelashes
Less common or rare:
  • Change in the color of the iris or eyelid
  • increase in number of eyelashes
  • difficulty seeing at night
  • increased sensitivity of eyes to sunlight

For Healthcare Professionals

Applies to unoprostone ophthalmic: ophthalmic solution

Ocular

Unoprostone ophthalmic may change the eye color. This is caused by a gradual increase of the brown pigment in the iris. The change in iris color is slow and may not be noticeable for months.

When administered to animals for 12 months, one of ten animals exhibited increased pigmentation of the iris.

The manufacturer reports after 12 months of therapy an increased length in eyelashes (>= 1 mm) in approximately 10% to 14% of patients and a decreased length in eyelashes in 7% of patients.[Ref]

Very common (10% or more): Burning/stinging, dry eyes, itching, increased length of eyelashes
Common (1% to 10%): Abnormal vision, eyelid disorder, foreign body sensation, lacrimation disorder, blepharitis, cataract, conjunctivitis, corneal lesion, discharge from the eye, eye hemorrhage, eye pain, keratitis, irritation, photophobia, vitreous disorder
Uncommon (0.1% to 1%): Acute elevated intraocular pressure, color blindness, corneal deposits, corneal edema, corneal opacity, diplopia, hyperpigmentation of the eyelid, increased number of eyelashes, iris hyperpigmentation, iritis, optic atrophy, ptosis, retinal hemorrhage, visual field defect, decrease in the length of eyelashes
Postmarketing reports: Corneal erosion, chemosis[Ref]

Respiratory

Common (1% to 10%): Bronchitis, increased cough, pharyngitis, rhinitis, sinusitis[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache[Ref]

Musculoskeletal

Common (1% to 10%): Back pain[Ref]

Metabolic

Common (1% to 10%): Diabetes mellitus[Ref]

Cardiovascular

Common (1% to 10%): Hypertension
Postmarketing reports: Palpitations[Ref]

Gastrointestinal

Postmarketing reports: Dry mouth, nausea, vomiting[Ref]

Other

Common (1% to 10%): Accidental injury, pain[Ref]

Hypersensitivity

Common (1% to 10%): Allergic reaction[Ref]

General

The most commonly reported side effects were burning/stinging, dry eyes, itching, and increased length of eyelashes.[Ref]

Immunologic

Common (1% to 10%): Flu-like syndrome[Ref]

Psychiatric

Common (1% to 10%): Insomnia[Ref]

References

1. "Product Information. Rescula (unoprostone ophthalmic)" Ciba Vision Ophthalmics, Duluth, GA.

It is possible that some side effects of unoprostone ophthalmic may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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