Ultiva Side Effects
Generic name: remifentanil
Medically reviewed by Drugs.com. Last updated on Jan 13, 2025.
Note: This document provides detailed information about Ultiva Side Effects associated with remifentanil. Some dosage forms listed on this page may not apply specifically to the brand name Ultiva.
Applies to remifentanil: intravenous powder for solution, intravenous solution.
Important warnings
This medicine can cause some serious health issues
Intravenous route (powder for solution)
Remifentanil exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death.
Assess each patient’s risk prior to prescribing remifentanil.
Precautions
Your doctor will check your progress closely while you or your child are receiving this medicine . This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.
Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with remifentanil (the active ingredient contained in Ultiva) may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. .
This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
Tell your doctor if you or your child have stiffness in the muscles of your neck, chest, hands, or legs after receiving this medicine.
Check with your doctor right away if you or your child have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.
This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.
Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn baby. Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Ultiva
Along with its needed effects, remifentanil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking remifentanil:
More common side effects
- blurred vision
- chest pain or discomfort
- confusion
- difficult or troubled breathing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- irregular, fast or slow, or shallow breathing
- lightheadedness, dizziness, or fainting
- muscle stiffness or tightness
- pale or blue lips, fingernails, or skin
- shortness of breath
- slow or irregular heartbeat
- sweating
- unusual tiredness or weakness
Less common side effects
- bluish lips or skin
- chills
- decrease in cardiac output
- fast, pounding, or heartbeat or pulse
- feeling of warmth
- fever
- headache
- nausea or vomiting
- nervousness
- not breathing
- pain after surgery
- pain in the shoulders, arms, jaw, or neck
- pounding in the ears
- problems with bleeding or clotting
- redness of the face, neck, arms, and occasionally, upper chest
- shivering
Rare side effects
- abdominal or stomach pain
- black, tarry stools
- bleeding gums
- blood in the urine or stools
- body aches or pain
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- congestion
- cough or hoarseness
- cough producing mucus
- coughing that sometimes produces a pink frothy sputum
- coughing up blood
- decreased frequency or amount of urine
- difficult, fast, or noisy breathing
- difficulty with swallowing
- disorientation
- dry mouth
- dryness or soreness of the throat
- dysphoria
- eye pain
- flushed, dry skin
- fruit-like breath odor
- general feeling of illness
- hiccups
- hives, itching, or skin rash
- increased blood pressure
- increased hunger
- increased menstrual flow or vaginal bleeding
- increased sweating
- increased thirst
- increased urination
- loss of appetite
- lower back or side pain
- muscle cramps or pain
- nervousness
- noisy breathing
- nosebleeds
- numbness or tingling in the hands, feet, or lips
- painful or difficult urination
- pale skin
- paralysis
- pinpoint red spots on the skin
- prolonged bleeding from cuts
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid heartbeat
- red or black, tarry stools
- red or dark brown urine
- runny nose
- seizures
- shakiness in the legs, arms, hands, or feet
- small clicking, bubbling, or rattling sounds in the lungs when listening with a stethoscope
- stuffy nose
- swelling in the legs and ankles
- swelling of the face, fingers, or lower legs
- tender, swollen glands in the neck
- tightness in the chest
- troubled breathing with exertion
- unexplained weight loss
- unusual bleeding or bruising
- voice changes
- vomiting
- weakness and heaviness of the legs
- weight gain
Other side effects of Ultiva
Some side effects of remifentanil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- anxiety
- blurred or loss of vision
- difficulty having a bowel movement (stool)
- disturbed color perception
- double vision
- halos around lights
- hyperventilation
- night blindness
- overbright appearance of lights
- pain at the injection site
- restlessness
- trouble with sleeping
- tunnel vision
Rare side effects
- burning while urinating
- heartburn
- hives or welts
- loss of bladder control
- loss of memory
- nightmares
- problems with memory
- seeing, hearing, or feeling things that are not there
- severe constipation
- severe vomiting
- trouble with urinating
- uncontrolled eye movements
For healthcare professionals
Applies to remifentanil: intravenous powder for injection, intravenous solution.
General adverse events
The most commonly reported adverse reactions have included respiratory depression, bradycardia, hypotension, and skeletal muscle rigidity. In pediatric patients, the most commonly reported events were nausea, vomiting, and shivering.[Ref]
Respiratory
- Common (1% to 10%): Respiratory depression
- Uncommon (0.1% to 1%): Apnea, hypoxia
- Frequency not reported: Cough, dyspnea, bronchospasm, laryngospasm, rhonchi, stridor, nasal congestion, pharyngitis, pleural effusion, hiccups, pulmonary edema, rales, bronchitis, rhinorrhea
Opioids:
- Frequency not reported: Serious respiratory depression
Cough, dyspnea, bronchospasm, laryngospasm, rhonchi, stridor, nasal congestion, pharyngitis, pleural effusion, hiccups, pulmonary edema, rales, bronchitis, and rhinorrhea have been reported in less than 1% of patients.
Cardiovascular
- Very common (10% or more): Hypotension (up to 19%)
- Common (1% to 10%): Bradycardia, atrial fibrillation, atrial flutter, myocardial ischemia, edema, flushing
- Uncommon (0.1% to 1%): Decreased cardiac output
- Rare (0.01% to 0.1%): Tachycardia, hypertension
- Frequency not reported: Various atrial and ventricular arrhythmias, heart block, ECG change consistent with myocardial ischemia, elevated CPK-MB level, syncope, premature ventricular beats, atrioventricular block
- Postmarketing reports: Asystole
Cardiovascular side effects such as hypotension and bradycardia have been reported to occur most frequently during the induction and maintenance period. Bradycardia and hypotension are probably due to a centrally mediated increase in vagal nerve activity. Glycopyrrolate, atropine and/or ephedrine may be useful in treating these effects. Unlike morphine, decreases in blood pressure are not due to histamine release.
In male patients and in those patient older 65 years, the incidence of hypotension is higher. Various atrial and ventricular arrhythmias, heart block, ECG change consistent with myocardial ischemia, elevated CPK-MB level, and syncope have been reported in less than 1% of patients.
Gastrointestinal
- Very common (10% or more): Nausea (up to 44%), vomiting (up to 22%)
- Common (1% to 10%): Constipation, heartburn
- Frequency not reported: Abdominal discomfort, xerostomia, gastro-esophageal reflux, dysphagia, diarrhea, ileus
Musculoskeletal
- Common (1% to 10%): Skeletal muscle rigidity
- Frequency not reported: Muscle stiffness, musculoskeletal chest pain
Gastrointestinal
Nausea has been reported to occur in very commonly, especially when used as a postoperative analgesic and upon discontinuation. Abdominal discomfort, xerostomia, gastro-esophageal reflux, dysphagia, diarrhea, and ileus have been reported in less than 1% of patients.
Musculoskeletal
Rigidity may be lessened by concomitant administration of a muscle relaxant. Muscle stiffness and musculoskeletal chest pain have been reported in less than 1% of patients.
Nervous system
- Common (1% to 10%): Dizziness, headache
- Frequency not reported: Serotonin syndrome, involuntary movement, prolonged emergence from anesthesia, awareness under anesthesia without pain, rapid awakening from anesthesia, tremors, paresthesia, nystagmus, twitch, seizure
Involuntary movement, prolonged emergence from anesthesia, awareness under anesthesia without pain, rapid awakening from anesthesia, tremors, paresthesia, nystagmus, twitch, and seizure have been reported in less than 1% of patients.
Hypersensitivity
- Frequency not reported: Anaphylactic reaction
Anaphylactic reaction was reported in less than 1% of patients.
Psychiatric
- Common (1% to 10%): Agitation
- Frequency not reported: Anxiety, confusion, disorientation, dysphoria, nightmares, hallucinations, amnesia
Anxiety, confusion, disorientation, dysphoria, nightmares, hallucinations, amnesia have been reported in less than 1% of patients.
Local
- Common (1% to 10%): Pain at IV site
- Frequency not reported: Erythema, pruritus, rash
Erythema, pruritus, and rash at the infusion site was reported in less than 1% of patients.
Dermatologic
- Common (1% to 10%): Pruritus, sweating
Rash and urticaria have been reported in less than 1% of patients.
Other
- Common (1% to 10%): Shivering, fever, chills, sensation of warmth
- Frequency not reported: Decreased body temperature
Hematologic
- Common (1% to 10%): Coagulation disorder
- Frequency not reported: Anemia, lymphopenia, leukocytosis, thrombocytopenia
Anemia, lymphopenia, leukocytosis, and thrombocytopenia have been reported in less than 1% of patients.
Ocular
- Common (1% to 10%): Visual disturbances
Metabolic
- Frequency not reported: Hyperglycemia, electrolyte disorders, increased CPK level
Genitourinary
- Frequency not reported: Urine retention, oliguria, dysuria, urine incontinence
Urine retention, oliguria, dysuria, and urine incontinence have been reported in less than 1% of patients.
Hepatic
- Frequency not reported: Abnormal liver function
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References
1. Cerner Multum, Inc. "Australian Product Information."
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Further information
Ultiva side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.