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Tussigon Side Effects

Generic Name: homatropine / hydrocodone

Note: This document contains side effect information about homatropine / hydrocodone. Some of the dosage forms listed on this page may not apply to the brand name Tussigon.

For the Consumer

Applies to homatropine / hydrocodone: oral solution, oral syrup, oral tablet

Along with its needed effects, homatropine/hydrocodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking homatropine / hydrocodone:

Incidence Not Known

  • Decrease in the frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • painful urination

Get emergency help immediately if any of the following symptoms of overdose occur while taking homatropine / hydrocodone:

Symptoms of Overdose

  • Difficult or troubled breathing
  • irregular, fast or slow, or shallow breathing
  • pale or blue lips, fingernails, or skin

Some side effects of homatropine / hydrocodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Incidence Not Known

  • Drowsiness
  • fear or nervousness
  • itching skin or rash
  • mood changes
  • relaxed and calm
  • sleepiness
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

For Healthcare Professionals

Applies to homatropine / hydrocodone: oral syrup, oral tablet


The more commonly reported adverse effects have included, drowsiness, dizziness, and difficulty urinating; nausea and vomiting have occurred and appear to be more frequent in ambulatory patients.[Ref]

Nervous system

One study has suggested that the respiratory depression caused by hydrocodone may be of benefit in the treatment of dyspnea related to chronic obstructive pulmonary disease and restrictive lung disease. However, the potential for the precipitation of respiratory insufficiency makes such use of hydrocodone hazardous and such use should be undertaken, if at all, only with extreme caution.[Ref]

Frequency not reported: Sedation, drowsiness, lethargy, mental and physical impairment, dizziness[Ref]


Frequency not reported: Dose-related respiratory depression including fatal respiratory depression


Postmarketing reports: Cardiorespiratory arrest[Ref]


Frequency not reported: Nausea, vomiting, constipation[Ref]


Postmarketing reports: Accidental overdose, death due to drug toxicity, non-accidental overdose, overdose[Ref]



Frequency not reported: Ureteral spasm, spasm of vesicle sphincters, urinary retention[Ref]


Postmarketing reports: Skin rash, pruritus[Ref]


Frequency not reported: Mental clouding, anxiety, fear, dysphoria, psychic dependence, mood changes


1. "Product Information. Homatropine Methylbromide-Hydrocodone (homatropine-hydrocodone)." KVK-Tech Inc, Newtown, PA.

2. Sackner MA "Effects of hydrocodone bitartrate on breathing pattern of patients with chronic obstructive pulmonary disease and restrictive lung disease." Mt Sinai J Med 51 (1984): 222-6

3. "Product Information. Hycodan (homatropine-hydrocodone)" Endo Laboratories LLC, Chadds Ford, PA.

4. Fricke J, Halladay SC, Bynum L, Francisco CA "Pain relief after dental impaction surgery using ketorolac, hydrocodone plus acetaminophen, or placebo." Clin Ther 15 (1993): 500-9

5. Morrison AB "Toxicity and abuse of hydrocodone bitartrate." Can Med Assoc J 120 (1979): 1338

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Tussigon (homatropine / hydrocodone)

Consumer resources

Other brands: Hycodan, Hydromet

Professional resources

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