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Truxazole Side Effects

Generic name: sulfisoxazole

Medically reviewed by Last updated on Mar 22, 2024.

Note: This document contains side effect information about sulfisoxazole. Some dosage forms listed on this page may not apply to the brand name Truxazole.

Applies to sulfisoxazole: compounding powder, oral suspension, oral tablet.


Take this medication for the full prescribed length of time. Your symptoms may get better before the infection is completely cleared. Sulfisoxazole will not treat a viral infection such as the common cold or flu.

Do not share this medication with another person, even if they have the same symptoms you have.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking sulfisoxazole and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Get emergency medical help if you have any of these signs of an allergic reaction while taking sulfisoxazole (the active ingredient contained in Truxazole) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

Less serious side effects of sulfisoxazole may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to sulfisoxazole: compounding powder, oral suspension, oral tablet.


In general, although not every side effect listed in the side effects section may have been reported with the use of sulfisoxazole (the active ingredient contained in Truxazole) they have all been reported with the use of one or more sulfonamide compounds.

Sulfisoxazole was generally well tolerated. Less than 0.1% of patients experienced serious side effects from sulfisoxazole.[Ref]


Hypersensitivity side effects have included anaphylaxis, erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis, angioedema, arteritis and vasculitis, serum sickness, conjunctival and scleral injection, generalized allergic reactions, and allergic myocarditis.[Ref]

The use of sulfonamide antibiotics is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis, although these phenomena are rare as a whole.[Ref]


Dermatologic side effects have included exfoliative dermatitis, rash, pruritus, photosensitivity, periarteritis nodosa, systemic lupus erythematosus, and generalized skin eruptions.[Ref]


Hematologic side effects have included agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia, purpura, hemolytic anemia, eosinophilia, clotting disorders including hypoprothrombinemia, hypofibrinogenemia, sulfhemoglobinemia, and methemoglobinemia.[Ref]


Hepatic side effects have included hepatitis, hepatocellular necrosis, and jaundice. Elevated liver-associated enzymes have been reported in patients with hepatitis. Rare cases of hepatic necrosis have been associated with some sulfonamides.[Ref]


Renal side effects have included elevated BUN and creatinine, acute renal failure, nephritis, and nephrosis with oliguria and anuria. The frequency of renal complications is lower with the more soluble sulfonamides, such as sulfisoxazole (the active ingredient contained in Truxazole) [Ref]


Genitourinary side effects have included crystalluria, hematuria, and urinary retention.


Cardiovascular side effects have included tachycardia, palpitations, syncope, cyanosis, angioedema, arteritis, and vasculitis.


Gastrointestinal side effects have included pseudomembranous colitis, nausea, emesis, anorexia, abdominal pain, diarrhea, gastrointestinal hemorrhage, melena, flatulence, glossitis, stomatitis, enlarged salivary gland, and pancreatitis.

Pseudomembranous colitis has occurred during or after sulfisoxazole therapy.

Nervous system

Nervous system side effects have included headache, dizziness, peripheral neuritis, paresthesia, convulsions, drowsiness, hearing loss, insomnia, tinnitus, vertigo, ataxia, and intracranial hypertension.[Ref]


Psychiatric side effects have included psychosis, hallucination, disorientation, depression, anxiety, and apathy.


Other side effects have included edema (including periorbital), pyrexia, weakness, fatigue, lassitude, rigors, flushing, and chills.


Respiratory side effects have included cough, shortness of breath, pulmonary infiltrates, and pneumonitis.


Musculoskeletal side effects have included arthralgia and myalgia.


Endocrine side effects have been reported rarely in patients receiving sulfonamides and have included goiter development, diuresis, and hypoglycemia.


1. "Multum Information Services, Inc. Expert Review Panel"

2. Flach A, Peterson J, Mathias T (1982) "Photosensitivity to topically applied sulfisoxazole ointment." Arch Ophthalmol, 100, p. 1286-7

3. Flach A (1981) "Photosensitivity to sulfisoxazole ointment." Arch Ophthalmol, 99, p. 609-10

4. Roujeau JC, Kelly JP, Naldi L, et al. (1995) "Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis." N Engl J Med, 333, p. 1600-7

5. Kounis GN, Kouni SA, Chiladakis JA, Kounis NG (2009) "Comment: Mesalamine-Associated Hypersensitivity Myocarditis in Ulcerative Colitis and the Kounis Syndrome (February)." Ann Pharmacother, 43, p. 393-4

6. (2001) "Product Information. Gantrisin (sulfisoxazole)." Roche Laboratories

7. Boyer W, Lake C (1983) "Interaction of phenelzine and sulfisoxazole." Am J Psychiatry, 140, p. 264-5

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.