Trimox Side Effects

Generic name: amoxicillin

Medically reviewed by Drugs.com. Last updated on Jan 23, 2025.

Note: This document provides detailed information about Trimox Side Effects associated with amoxicillin. Some dosage forms listed on this page may not apply specifically to the brand name Trimox.

Applies to amoxicillin: oral capsule, oral powder for suspension, oral tablet, oral tablet chewable, oral tablet extended release.

Precautions

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

This medicine may cause a serious allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a skin rash; itching; shortness of breath; trouble with breathing; trouble with swallowing; or any swelling of your hands, face, mouth, or throat after you or your child receive this medicine.

Amoxicillin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you Stop taking amoxicillin (the active ingredient contained in Trimox) Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Before you have any medical tests, tell the doctor in charge that you or your child are taking this medicine. The results of some tests may be affected by this medicine.

In some young patients, tooth discoloration may occur while using this medicine. The teeth may appear to have brown, yellow, or gray stains. To help prevent this, brush and floss your teeth regularly or have a dentist clean your teeth.

Birth control pills may not work while you are using this medicine. To keep from getting pregnant, use another form of birth control along with your birth control pills. Other forms include a condom, a diaphragm, or a contraceptive foam or jelly.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Trimox

Some side effects of amoxicillin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Trimox

Along with its needed effects, amoxicillin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin:

For healthcare professionals

Applies to amoxicillin: oral capsule, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet dispersible, oral tablet extended release.

General adverse events

The most frequently reported side effects were diarrhea, nausea, and skin rash.^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea, nausea, abdominal pain
• Uncommon (0.1% to 1%): Vomiting
• Frequency not reported: Hemorrhagic/pseudomembranous colitis, tooth discolored, black hairy tongue, glossitis, stomatitis
• Postmarketing reports: Sore mouth/tongue^[Ref]

Dermatologic

• Common (1% to 10%): Erythema, exanthema, rash
• Uncommon (0.1% to 1%): Urticaria, pruritus
• Very rare (less than 0.01%): Angioedema, hypersensitivity vasculitis
• Frequency not reported: Erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson Syndrome, bullous dermatitis, exfoliative dermatitis, toxic epidermal necrolysis/Lyell's syndrome, acute generalized exanthematous pustulosis, maculopapular rash, erythema nodosum, pemphigoid reactions^[Ref]

Genitourinary

• Common (1% to 10%): Vulvovaginal mycotic infection^[Ref]

Nervous system

• Common (1% to 10%): Headache, taste perversion
• Very rare (less than 0.01%): Convulsion, dizziness, hyperkinesia
• Frequency not reported: Reversible hyperactivity, central nervous system toxicity, encephalopathy^[Ref]

Immunologic

• Very rare (less than 0.01%): Anaphylaxis, serum sickness-like reaction
• Frequency not reported: Jarisch-Herxheimer reaction^[Ref]

Renal

• Very rare (less than 0.01%): Crystalluria, interstitial nephritis
• Frequency not reported: Nephropathy^[Ref]

Hematologic

• Very rare (less than 0.01%): Leucopenia, severe neutropenia, agranulocytosis, hemolytic anemia, thrombocytopenia, bleeding time prolonged, prothrombin time prolonged
• Frequency not reported: Anemia, thrombocytopenic purpura, eosinophilia, platelet function defective, lymphadenopathy^[Ref]

Other

• Common (1% to 10%): Candidiasis, fungal/mycotic infection
• Very rare (less than 0.01%): Mucocutaneous candidiasis
• Frequency not reported: Intestinal candidiasis, oral moniliasis, vaginal moniliasis, fever, chills^[Ref]

Hepatic

• Very rare (less than 0.01%): Hepatitis, cholestatic jaundice, AST increased, ALT increased
• Frequency not reported: Hepatic dysfunction, hepatic cholestasis, acute cytolytic hepatitis^[Ref]

Respiratory

• Frequency not reported: Bronchospasm, acute severe dyspnea, pneumonitis allergic^[Ref]

Local

• Frequency not reported: Phlebitis, injection site pain^[Ref]

Metabolic

• Frequency not reported: Electrolyte disturbance, hypokalemia^[Ref]

Musculoskeletal

• Frequency not reported: Joint pain, arthralgia^[Ref]

Psychiatric

• Frequency not reported: Agitation, anxiety, insomnia, confusion, behavior changed, hallucination^[Ref]

See also:

Frequently asked questions

• What are the best antibiotics for a tooth infection?
• Can you drink alcohol with amoxicillin?
• Does amoxicillin expire? Is it safe to take after expiration?
• Is amoxicillin safe for dogs?
• Amoxicillin rash: When should I be concerned?
• What is the best antibiotic to treat strep throat?
• Does amoxicillin help with tooth infection and pain?
• What's the difference between amoxicillin and penicillin?
• What are the best antibiotics for pneumonia?

Further information

Trimox side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer