Tranxene T-Tab Side Effects
Generic name: clorazepate
Medically reviewed by Drugs.com. Last updated on Sep 12, 2024.
Note: This document provides detailed information about Tranxene T-Tab Side Effects associated with clorazepate. Some dosage forms listed on this page may not apply specifically to the brand name Tranxene T-Tab.
Applies to clorazepate: oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
Risks from Concomitant Use with Opioids; Abuse, Misuse, and Addiction; and Dependence and Withdrawal Reactions. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.
Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate.
Limit dosages and durations to the minimum required.
Follow patients for signs and symptoms of respiratory depression and sedation.The use of benzodiazepines, including clorazepate, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death.
Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes.
Before prescribing clorazepate and throughout out treatment, assess each patient’s risk for abuse, misuse, and addiction.The continued use of benzodiazepines, including clorazepate, may lead to clinically significant physical dependence.
The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose.
Abrupt discontinuation or rapid dosage reduction of clorazepate after continued use may precipitate acute withdrawal reactions, which can be life-threatening.
To reduce the risk of withdrawal reactions, use a gradual taper to discontinue clorazepate or reduce the dosage.
Serious side effects of Tranxene T-Tab
Along with its needed effects, clorazepate (the active ingredient contained in Tranxene T-Tab) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking clorazepate:
Less common side effects
- bladder pain
- bloody or cloudy urine
- difficult, burning, or painful urination
- frequent urge to urinate
- lower back or side pain
- shakiness and unsteady walk
- slurred speech
- trembling or shaking of the hands or feet
- unsteadiness, trembling, or other problems with muscle control or coordination
Get emergency help immediately if any of the following symptoms of overdose occur while taking clorazepate:
Symptoms of overdose
- agitation
- change in consciousness
- changes in patterns and rhythms of speech
- drowsiness
- loss of consciousness
- loss of strength or energy
- mood or mental changes
- nightmares
- shakiness and unsteady walk
- sleepiness
- slurred speech
- talkativeness
- trouble speaking
- unsteadiness, trembling, or other problems with muscle control or coordination
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- unusual excitement, nervousness, restlessness, or irritability
Other side effects of Tranxene T-Tab
Some side effects of clorazepate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- blurred vision
- diarrhea
- discouragement
- dizziness
- double vision
- dry mouth
- feeling sad or empty
- headache
- indigestion
- irritability
- loss of appetite
- loss of interest or pleasure
- mental confusion
- nausea or vomiting
- nervousness
- passing of gas
- seeing double
- skin rash
- stomach pain, fullness, or discomfort
- trouble with concentrating
- trouble with sleeping
- unusual tiredness or weakness
For healthcare professionals
Applies to clorazepate: oral tablet.
General adverse events
The most commonly reported side effect was drowsiness.[Ref]
Nervous system
- Frequency not reported: Ataxia, dizziness, drowsiness, headache, nervousness, slurred speech[Ref]
Psychiatric
- Frequency not reported: Depression, insomnia, irritability, mental confusion, suicidal ideation/behavior[Ref]
Gastrointestinal
- Frequency not reported: Dry mouth, various gastrointestinal complaints[Ref]
Ocular
- Frequency not reported: Blurred vision, diplopia[Ref]
Dermatologic
- Frequency not reported: Transient skin rash[Ref]
Other
Genitourinary
- Frequency not reported: Genitourinary complaints[Ref]
Hepatic
- Frequency not reported: Abnormal liver function tests[Ref]
Renal
- Frequency not reported: Abnormal kidney function tests[Ref]
Hematologic
- Frequency not reported: Decreased hematocrit[Ref]
Cardiovascular
- Frequency not reported: Decrease in systolic blood pressure[Ref]
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References
1. (2001) "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical
More about Tranxene T-Tab (clorazepate)
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Further information
Tranxene T-Tab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
