Skip to main content

Transderm-Scop Side Effects

Generic name: scopolamine

Medically reviewed by Last updated on Dec 21, 2023.

Note: This document contains side effect information about scopolamine. Some dosage forms listed on this page may not apply to the brand name Transderm-Scop.

Applies to scopolamine: transdermal patch extended release.

Serious side effects of Transderm-Scop

Along with its needed effects, scopolamine (the active ingredient contained in Transderm-Scop) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking scopolamine:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking scopolamine:

Symptoms of overdose

Other side effects of Transderm-Scop

Some side effects of scopolamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

More common

For Healthcare Professionals

Applies to scopolamine: compounding powder, injectable solution, oral tablet, transdermal film extended release.


The most commonly reported side effects included dry mouth, dizziness, and somnolence.[Ref]


Very common (10% or more): Dry mouth (up to 66.7%)

Rare (0.01% to 0.1%): Nausea, vomiting

Frequency not reported: Constipation, gastrointestinal disorders, mild to moderate gastrointestinal tract symptoms, swallowing difficulty[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 16.7%)

Common (1% to 10%): Drowsiness, sedation, somnolence

Uncommon (0.1% to 1%): Central nervous system simulation

Rare (0.01% to 0.1%): Attention disturbance, balance disturbances, headache, increased seizure frequency, memory impairment

Frequency not reported: Anticholinergic effects, coma, dystonia, eclamptic seizures, loss of consciousness, neuroleptic malignant syndrome

Postmarketing reports: Coordination abnormalities, speech disorder, vertigo[Ref]

Increased seizure frequency occurred in patients with epilepsy.

Eclamptic seizures occurred in pregnant patients.[Ref]


Common (1% to 10%): Accommodation disorder, blurred vision, cycloplegia, eyelid irritation, mydriasis/unilateral mydriasis, myopia, pupil dilation, visual accommodation disorder, visual impairment

Very rare (less than 0.01%): Acute glaucoma precipitation, closed angle glaucoma, narrow angle glaucoma

Frequency not reported: Acute angle closure glaucoma, angle closure glaucoma, increased intraocular pressure, loss of accommodation, periorbital swelling, photophobia

Postmarketing reports: Amblyopia, dry eyes, eye pruritus[Ref]


Common (1% to 10%): Agitation, confusion

Uncommon (0.1% to 1%): Hallucinations, restlessness

Rare (0.01% to 0.1%): Disorientation, visual hallucinations

Frequency not reported: Delirium, mental confusion, mental excitement, neuropsychiatric adverse reactions, psychiatric disorders, psychotic disorder

Postmarketing reports: Acute psychosis, paranoia[Ref]


Common (1% to 10%): Skin irritation

Uncommon (0.1% to 1%): Abnormal sweating, pruritus, skin reactions, urticaria

Very rare (less than 0.01%): Generalized rash

Frequency not reported: Decreased sweating, dyshidrosis, dry skin, erythema, mild to moderate skin reactions, rash[Ref]


Common (1% to 10%): Tachycardia

Frequency not reported: Arrhythmias, cardiorespiratory distress, decreased blood pressure, edema, flushing, mild to moderate cardiovascular system symptoms, palpitations, transient bradycardia[Ref]


Common (1% to 10%): Pharyngitis

Frequency not reported: Asthma syndrome, dyspnea, mild to moderate respiratory tract reactions, reduced bronchial secretions[Ref]


Rare (0.01% to 0.1%): Urinary retention

Frequency not reported: Impaired micturition, micturition difficulty, urinary disorders, urinary disturbances, urinary emergency

Postmarketing reports: Dysuria[Ref]


Frequency not reported: Allergic reaction, anaphylactic reactions, anaphylactic shock/fatal anaphylactic shock, anaphylactoid reactions, hypersensitivity reactions with respective clinical/laboratory manifestations, other hypersensitivity[Ref]


Frequency not reported: Drug withdrawal symptoms/post-removal symptoms, hyperthermia at high temperatures (decreased sweating), idiosyncratic reactions[Ref]


Frequency not reported: Injection site pain, MRI skin burns/application site burning (patch)[Ref]


Frequency not reported: Facial swelling[Ref]


Frequency not reported: Thirst[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Cerner Multum, Inc. "Australian Product Information."

3. (2022) "Product Information. Transderm-Scop (scopolamine)." Sandoz Inc

4. "Product Information. Scopolamine (scopolamine)." Perrigo, L. Company

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.