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Tirofiban Side Effects

For the Consumer

Applies to tirofiban: intravenous solution

Along with its needed effects, tirofiban may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking tirofiban:

More common
  • Abdominal or stomach pain or swelling
  • arm, back, or jaw pain
  • black, tarry stools
  • blood in the eyes
  • blood in the urine
  • bruising or purple areas on the skin
  • chest pain or discomfort
  • chest tightness or heaviness
  • coughing up blood
  • decreased alertness
  • fast or irregular heartbeat
  • headache
  • joint pain or swelling
  • nausea
  • nosebleeds
Less common
  • Bleeding gums
  • lightheadedness or fainting
  • pinpoint red spots on the skin
  • severe, unusual tiredness or weakness
  • slow heartbeat
  • swelling of the hands, ankles, feet, or lower legs
Incidence not known
  • Chills or fever
  • cough
  • difficulty swallowing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash, hives, or itching
  • trouble breathing

Some side effects of tirofiban may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Pain in the legs or hips
Less common

For Healthcare Professionals

Applies to tirofiban: intravenous powder for injection, intravenous solution


Bleeding is the most common adverse reaction. Clinical trial adverse reactions were reported in patients taking this drug in addition to heparin.[Ref]


Very common (10% or more): Thrombolysis in myocardial infarction (TIMI) minor bleeding (up to 10.5%)
Common (1% to 10%): TIMI major bleeding, transfusions, platelets decreased to less than 90,000 cells/mm3
Uncommon (0.1% to 1%): Platelets decreased to less than 50,000 cells/mm3
Postmarketing reports: Platelets decreased to less than 10,000 cells/mm3, fatal bleeding[Ref]

Nervous system

Common (1% to 10%): Vasovagal reaction, dizziness, headache
Postmarketing reports: Intracranial bleeding[Ref]


Common (1% to 10%): Bradycardia, coronary artery dissection
Postmarketing reports: Hemopericardium[Ref]


Common (1% to 10%): Nausea
Postmarketing reports: Retroperitoneal bleeding[Ref]


Common (1% to 10%): Edema/swelling
Postmarketing reports: Spinal epidural hematoma[Ref]


Common (1% to 10%): Sweating[Ref]


Common (1% to 10%): Pelvic pain[Ref]


Common (1% to 10%): Leg pain[Ref]


Postmarketing reports: Severe allergic reactions, anaphylactic reactions[Ref]


Postmarketing reports: Pulmonary hemorrhage[Ref]


1. "Product Information. Aggrastat (tirofiban)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of tirofiban may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.