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Tirofiban Side Effects

For the Consumer

Applies to tirofiban: intravenous solution

As well as its needed effects, tirofiban may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking tirofiban, check with your doctor or nurse immediately:

More common:
  • Abdominal or stomach pain or swelling
  • arm, back, or jaw pain
  • black, tarry stools
  • blood in the eyes
  • blood in the urine
  • bruising or purple areas on the skin
  • chest pain or discomfort
  • chest tightness or heaviness
  • coughing up blood
  • decreased alertness
  • fast or irregular heartbeat
  • headache
  • joint pain or swelling
  • nausea
  • nosebleeds
Less common:
  • Bleeding gums
  • lightheadedness or fainting
  • pinpoint red spots on the skin
  • severe, unusual tiredness or weakness
  • slow heartbeat
  • swelling of the hands, ankles, feet, or lower legs
Incidence not known:
  • Chills or fever
  • cough
  • difficulty swallowing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash, hives, or itching
  • trouble breathing

Minor Side Effects

Some tirofiban side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Pain in the legs or hips
Less common:
  • Dizziness
  • sweating

For Healthcare Professionals

Applies to tirofiban: intravenous powder for injection, intravenous solution

General

Bleeding is the most common adverse reaction. Clinical trial adverse reactions were reported in patients taking this drug in addition to heparin.[Ref]

Hematologic

Very common (10% or more): Thrombolysis in myocardial infarction (TIMI) minor bleeding (up to 10.5%)
Common (1% to 10%): TIMI major bleeding, transfusions, platelets decreased to less than 90,000 cells/mm3
Uncommon (0.1% to 1%): Platelets decreased to less than 50,000 cells/mm3
Postmarketing reports: Platelets decreased to less than 10,000 cells/mm3, fatal bleeding[Ref]

Nervous system

Common (1% to 10%): Vasovagal reaction, dizziness, headache
Postmarketing reports: Intracranial bleeding[Ref]

Cardiovascular

Common (1% to 10%): Bradycardia, coronary artery dissection
Postmarketing reports: Hemopericardium[Ref]

Gastrointestinal

Common (1% to 10%): Nausea
Postmarketing reports: Retroperitoneal bleeding[Ref]

Other

Common (1% to 10%): Edema/swelling
Postmarketing reports: Spinal epidural hematoma[Ref]

Dermatologic

Common (1% to 10%): Sweating[Ref]

Genitourinary

Common (1% to 10%): Pelvic pain[Ref]

Musculoskeletal

Common (1% to 10%): Leg pain[Ref]

Immunologic

Postmarketing reports: Severe allergic reactions, anaphylactic reactions[Ref]

Respiratory

Postmarketing reports: Pulmonary hemorrhage[Ref]

References

1. "Product Information. Aggrastat (tirofiban)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of tirofiban may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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