Tirofiban Side Effects
Medically reviewed by Drugs.com. Last updated on Mar 24, 2024.
Applies to tirofiban: intravenous solution.
Serious side effects of tirofiban
Along with its needed effects, tirofiban may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking tirofiban:
More common side effects
- abdominal or stomach pain or swelling
- arm, back, or jaw pain
- black, tarry stools
- blood in the eyes
- blood in the urine
- bruising or purple areas on the skin
- chest pain or discomfort
- chest tightness or heaviness
- coughing up blood
- decreased alertness
- fast or irregular heartbeat
- headache
- joint pain or swelling
- nausea
- nosebleeds
Less common side effects
- bleeding gums
- lightheadedness or fainting
- pinpoint red spots on the skin
- severe, unusual tiredness or weakness
- slow heartbeat
- swelling of the hands, ankles, feet, or lower legs
Incidence not known
- chills or fever
- cough
- difficulty swallowing
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- skin rash, hives, or itching
- trouble breathing
Other side effects of tirofiban
Some side effects of tirofiban may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- pain in the legs or hips
Less common side effects
- dizziness
- sweating
For healthcare professionals
Applies to tirofiban: intravenous powder for injection, intravenous solution.
General adverse events
Bleeding is the most common adverse reaction. Clinical trial adverse reactions were reported in patients taking this drug in addition to heparin.[Ref]
Hematologic
- Very common (10% or more): Thrombolysis in myocardial infarction (TIMI) minor bleeding (up to 10.5%)
- Common (1% to 10%): TIMI major bleeding, transfusions, platelets decreased to less than 90,000 cells/mm3
- Uncommon (0.1% to 1%): Platelets decreased to less than 50,000 cells/mm3
- Postmarketing reports: Platelets decreased to less than 10,000 cells/mm3, fatal bleeding[Ref]
Nervous system
- Common (1% to 10%): Vasovagal reaction, dizziness, headache
- Postmarketing reports: Intracranial bleeding[Ref]
Cardiovascular
- Common (1% to 10%): Bradycardia, coronary artery dissection
- Postmarketing reports: Hemopericardium[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea
- Postmarketing reports: Retroperitoneal bleeding[Ref]
Other
Dermatologic
- Common (1% to 10%): Sweating[Ref]
Genitourinary
- Common (1% to 10%): Pelvic pain[Ref]
Musculoskeletal
- Common (1% to 10%): Leg pain[Ref]
Immunologic
- Postmarketing reports: Severe allergic reactions, anaphylactic reactions[Ref]
Respiratory
- Postmarketing reports: Pulmonary hemorrhage[Ref]
References
1. (2001) "Product Information. Aggrastat (tirofiban)." Merck & Co., Inc
2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
3. Cerner Multum, Inc. "Australian Product Information."
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Further information
Tirofiban side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.