Medically reviewed by Drugs.com. Last updated on Feb 8, 2021.
Applies to the following strengths: 250 mcg/mL; 50 mcg/mL
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Acute Coronary Syndrome
Initial dose: 25 mcg/kg IV within 5 minutes
Maintenance dose: 0.15 mcg/kg/min IV infusion for up to 18 hours
Use: To reduce the rate of thrombotic cardiovascular events in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
Renal Dose Adjustments
CrCl greater than 60 mL/min: Data not available
CrCl 60 mL/min or less: Following usual bolus dose, initiate constant infusion at 0.075 mcg/kg/min.
Liver Dose Adjustments
Data not available
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
-Do not freeze.
-Protect from light.
Reconstitution/preparation techniques: The manufacturer product information should be consulted.
-Do not administer through the same IV line as diazepam.
-Do not add other drugs or remove solution directly with a syringe.
-Do not use plastic containers in series connections.
-Hematologic: Platelet counts, hemoglobin, and hematocrit prior to treatment, 6 hours after the initial dose, and daily thereafter; platelet counts to exclude pseudothrombocytopenia if platelets decrease to less than 90,000 cells/mm3; activated partial thromboplastin time (aPTT) prior to treatment and regularly thereafter to determine the anticoagulant effects of heparin.
Patient advice: Advise patients to report any signs of bleeding or bruising to their healthcare provider.
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