Medically reviewed by Drugs.com. Last updated on Feb 18, 2019.
Applies to the following strengths: 250 mcg/mL; 50 mcg/mL
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Acute Coronary Syndrome
Initial dose: 25 mcg/kg IV within 5 minutes
Maintenance dose: 0.15 mcg/kg/min IV infusion for up to 18 hours
Use: To reduce the rate of thrombotic cardiovascular events in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
Renal Dose Adjustments
CrCl greater than 60 mL/min: Data not available
CrCl 60 mL/min or less: Following usual bolus dose, initiate constant infusion at 0.075 mcg/kg/min.
Liver Dose Adjustments
Data not available
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
-Do not freeze.
-Protect from light.
Reconstitution/preparation techniques: The manufacturer product information should be consulted.
-Do not administer through the same IV line as diazepam.
-Do not add other drugs or remove solution directly with a syringe.
-Do not use plastic containers in series connections.
-Hematologic: Platelet counts, hemoglobin, and hematocrit prior to treatment, 6 hours after the initial dose, and daily thereafter; platelet counts to exclude pseudothrombocytopenia if platelets decrease to less than 90,000 cells/mm3; activated partial thromboplastin time (aPTT) prior to treatment and regularly thereafter to determine the anticoagulant effects of heparin.
Patient advice: Advise patients to report any signs of bleeding or bruising to their healthcare provider.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Other brands: Aggrastat