Tezepelumab Side Effects

Medically reviewed by Drugs.com. Last updated on May 25, 2024.

Applies to tezepelumab: subcutaneous solution.

Common side effects of tezepelumab

Some side effects of tezepelumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• back pain
• body aches or pain
• cough
• difficulty in moving
• dryness or soreness of the throat
• fever
• muscle pain or stiffness
• redness, pain, or itching at the injection site
• stuffy or runny nose
• tender, swollen glands in the neck
• trouble swallowing
• voice changes

Serious side effects of tezepelumab

Along with its needed effects, tezepelumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tezepelumab:

Incidence not known

• burning, dry, or itching eyes
• chest tightness
• discharge, excessive tearing
• fast heartbeat
• hives, itching, skin rash
• hoarseness
• irritation
• joint pain, stiffness, or swelling
• lightheadedness, dizziness, or fainting
• redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
• redness of the skin
• swelling of the eyelids, face, lips, mouth, tongue, hands, or feet
• trouble breathing

For healthcare professionals

Applies to tezepelumab: subcutaneous solution.

General

The most common adverse reactions included pharyngitis, arthralgia, and back pain. The safety profile in pediatric patients was generally similar to the overall study population.^[Ref]

Cardiovascular

• Frequency not reported: MACE (major adverse cardiovascular events)

One clinical trial observed higher incidence rates per 100 patient-years for both serious cardiac adverse events and MACE in patients treated with this drug as compared to placebo; however, the clinical implications of these findings were not described by the manufacturer.

Dermatologic

• Common (1% to 10%): Rash

Rash included rash, pruritic rash, erythematous rash, maculopapular rash, and macular rash.

Hypersensitivity

• Postmarketing reports: Anaphylaxis

Immunologic

• Common (1% to 10%): Anti-drug antibodies

Local

• Common (1% to 10%): Injection site reactions

Injection site reactions included injection site erythema, injection site swelling, and injection site pain.

In one clinical study, injection site reactions were observed in a higher percentage of patients who used the prefilled pen (5.7%) versus the prefilled syringe (0%).

Musculoskeletal

• Common (1% to 10%): Arthralgia, back pain

Respiratory

• Common (1% to 10%): Pharyngitis

Pharyngitis included pharyngitis, bacterial pharyngitis, streptococcal pharyngitis, and viral pharyngitis.

Frequently asked questions

• How do I use the Tezspire pen?

Further information

Tezepelumab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer