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Tezepelumab Side Effects

Medically reviewed by Last updated on Jun 23, 2023.

Applies to tezepelumab: subcutaneous solution.

Serious side effects of Tezepelumab

Along with its needed effects, tezepelumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tezepelumab:

Incidence not known

  • Burning, dry, or itching eyes
  • chest tightness
  • discharge, excessive tearing
  • fast heartbeat
  • hives, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • lightheadedness, dizziness, or fainting
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • redness of the skin
  • swelling of the eyelids, face, lips, mouth, tongue, hands, or feet
  • trouble breathing

Other side effects of Tezepelumab

Some side effects of tezepelumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Back pain
  • body aches or pain
  • cough
  • difficulty in moving
  • dryness or soreness of the throat
  • fever
  • muscle pain or stiffness
  • redness, pain, or itching at the injection site
  • stuffy or runny nose
  • tender, swollen glands in the neck
  • trouble swallowing
  • voice changes

For Healthcare Professionals

Applies to tezepelumab: subcutaneous solution.


The most reported adverse reactions have included pharyngitis, arthralgia, and back pain.[Ref]


Common (1% to 10%): Pharyngitis (including bacterial, streptococcal, and viral pharyngitis)


Common (1% to 10%): Anti-drug antibodies


Common (1% to 10%): Arthralgia, back pain


Common (1% to 10%): Injection site reactions (e.g., injection site erythema, injection site swelling, injection site pain)

Frequently asked questions


1. Product Information. Tezspire (tezepelumab). Amgen USA. 2021.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.