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Teriparatide Side Effects

In Summary

Commonly reported side effects of teriparatide include: arthralgia, pain, and rhinitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to teriparatide: subcutaneous solution

Along with its needed effects, teriparatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as bone cancer. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur while taking teriparatide:

More common Less common
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • cough
  • difficult or labored breathing
  • fainting
  • fast or irregular heartbeat
  • fever or chills
  • nausea
  • shortness of breath
  • sneezing
  • sore throat
  • sweating
  • tightness in the chest
  • wheezing
Incidence not known
  • Hives or welts
  • itching
  • redness of the skin
  • skin rash
  • swelling or puffiness of the mouth and face

Some side effects of teriparatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching
  • blurred vision
  • body aches or pain
  • congestion
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness
  • heartburn
  • hoarseness
  • indigestion
  • lack or loss of strength
  • muscle pain or stiffness
  • muscle spasm
  • nervousness
  • pain in the joints
  • pounding in the ears
  • runny nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
Less common
  • Abdominal or stomach cramps
  • back pain
  • discomfort
  • discouragement
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • indigestion
  • irritability
  • lack of appetite
  • leg cramps
  • loss of interest or pleasure
  • neck pain
  • rash
  • sensation of spinning
  • sleeplessness
  • swollen mouth and tongue
  • tiredness
  • tooth disorder
  • trouble concentrating
  • trouble sleeping
  • unpleasant taste
  • urge to have bowel movement
Rare
  • Pain at the place of injection during or following the injection
  • tingling feeling in the hands and feet
  • urge for bowel movement
Incidence not known
  • Bruising at the injection site
  • flushing
  • minor bleeding at the injection site
  • unusually warm skin

For Healthcare Professionals

Applies to teriparatide: subcutaneous device

Cardiovascular

Common (1% to 10%): Hypotension, hypertension, palpitations, chest pain, angina pectoris
Uncommon (0.1% to 1%): Tachycardia, cardiac murmur
Frequency not reported: Peripheral edema[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, hiatus hernia, gastro-esophageal reflux disease, constipation, diarrhea, dyspepsia, gastrointestinal disorder, tooth disorder
Uncommon (0.1% to 1%): Hemorrhoids[Ref]

Musculoskeletal

Very common (10% or more): Pain in limb, arthralgia (10%)
Common (1% to 10%): Muscle cramps, neck pain, leg cramps
Uncommon (0.1% to 1%): Myalgia, arthralgia, back cramp/pain[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, sciatica, syncope[Ref]

Respiratory

Common (1% to 10%): Dyspnea, rhinitis, cough increased, pharyngitis, pneumonia
Uncommon (0.1% to 1%): Emphysema[Ref]

Dermatologic

Common (1% to 10%): Rash, sweating increased[Ref]

Endocrine

Frequency not reported: Transient hypoparathyroidism[Ref]

Hypersensitivity

Rare (less than 0.1%): Anaphylaxis, possible allergic events soon after injection (e.g., acute dyspnea, oro/facial edema, generalized urticaria, chest pain, edema (mainly peripheral)
Postmarketing reports: Drug hypersensitivity, angioedema, urticaria[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Local

Common (1% to 10%): Mild and transient injection site events (e.g., pain, swelling, erythema, localized bruising, pruritus, minor bleeding at injection site)
Uncommon (0.1% to 1%): Injection site erythema, injection site reaction[Ref]

Metabolic

Common (1% to 10%): Hypercholesterolemia
Uncommon (0.1% to 1%): Hypercalcemia (greater than 2.76 mmol/L), hyperuricemia, weight gain, alkaline phosphatase increase[Ref]

Other

Very common (10% or more): Pain (21%)
Common (1% to 10%): Vertigo, fatigue, asthenia, syncope[Ref]

Psychiatric

Common (1% to 10%): Depression, insomnia[Ref]

Renal

Uncommon (0.1% to 1%): Urinary incontinence, polyuria, micturition urgency, nephrolithiasis
Rare (less than 0.1%): Renal failure/impairment[Ref]

Oncologic

Frequency not reported: Osteosarcoma[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Forteo (teriparatide)." Lilly, Eli and Company, Indianapolis, IN.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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