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Teriparatide Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 17, 2025.

Applies to teriparatide: subcutaneous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your risk of having osteosarcoma (bone cancer). This is more likely to occur if you have a history of radiation treatment involving your bones. Check with your doctor right away if you have bone pain that does not go away or a new soft tissue mass that is tender to palpation.

This medicine may increase levels of calcium in the blood and urine. High calcium in the urine may cause kidney stones. Call your doctor right away if you have blood in the urine, confusion, constipation, dry mouth, metallic taste, muscle weakness, nausea or vomiting, pain in the side, back, or stomach, or weight loss.

This medicine may cause some people to become dizzy or drowsy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of teriparatide

Along with its needed effects, teriparatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking teriparatide:

More common side effects

  • confusion
  • constipation
  • depression
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • loss of appetite
  • metallic taste
  • muscle weakness
  • nausea
  • stomach pain
  • thirst
  • unusual tiredness
  • vomiting
  • weight loss

Less common side effects

  • arm, back, or jaw pain
  • chest pain, discomfort, tightness, or heaviness
  • cough
  • fainting
  • fast or irregular heartbeat
  • fever or chills
  • nausea
  • sneezing
  • sore throat
  • sweating
  • trouble breathing

Incidence not known

  • hives or welts, itching, skin rash
  • redness of the skin
  • swelling or puffiness of the mouth and face

Other side effects of teriparatide

Some side effects of teriparatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • acid or sour stomach
  • belching
  • blurred vision
  • body aches or pain
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness
  • heartburn
  • hoarseness
  • indigestion
  • lack or loss of strength
  • muscle pain, stiffness, or spasm
  • nervousness
  • pain in the joints
  • pounding in the ears
  • runny or stuffy nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes

Less common side effects

  • back pain
  • discomfort
  • discouragement
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • indigestion
  • irritability
  • lack of appetite
  • leg cramps
  • loss of interest or pleasure
  • neck pain
  • sensation of spinning
  • sleeplessness
  • stomach cramps
  • swollen mouth and tongue
  • tiredness
  • tooth disorder
  • trouble concentrating
  • trouble sleeping
  • unpleasant taste
  • urge to have bowel movement

Incidence not known

  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • flushing
  • unusually warm skin

For healthcare professionals

Applies to teriparatide: subcutaneous solution.

General adverse events

The more commonly reported side effects have included arthralgia, pain, and nausea.

Hypersensitivity

Oncologic

Cases of bone tumor and osteosarcoma have been reported during the postmarketing period; however, an increased risk of osteosarcoma was not observed in observational studies. Two osteosarcoma surveillance safety studies (US claims-based database studies) designed to assess the incidence rate of osteosarcoma showed 3 osteosarcoma cases among 379,283 patients and zero cases among 153,316 patients receiving this drug. A similar risk for osteosarcoma has been observed with comparators. The interpretation of these results suggests caution as data sources do not allow for complete measurement and control for confounders.[Ref]

Genitourinary

Cardiovascular

Gastrointestinal

Musculoskeletal

Nervous system

Respiratory

Dermatologic

Endocrine

Hematologic

Local

Metabolic

Other

Psychiatric

Renal

See also:

References

1. (2002) "Product Information. Forteo (teriparatide)." Lilly, Eli and Company

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Frequently asked questions

Further information

Teriparatide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.