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Sular Side Effects

Generic name: nisoldipine

Medically reviewed by Last updated on May 21, 2023.

Note: This document contains side effect information about nisoldipine. Some dosage forms listed on this page may not apply to the brand name Sular.

Applies to nisoldipine: oral tablet extended release.

Serious side effects of Sular

Along with its needed effects, nisoldipine (the active ingredient contained in Sular) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nisoldipine:

More common

Less common


Other side effects of Sular

Some side effects of nisoldipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to nisoldipine: oral tablet extended release.


The most commonly reported side effects included peripheral edema, headache, dizziness, and pharyngitis.[Ref]


Peripheral edema occurred as a dose-related event, with the highest frequency (27%) reported in patients receiving doses of 34 mg/day.

Peripheral edema and vasodilation were more commonly reported in white patients.[Ref]

Very common (10% or more): Peripheral edema (up to 22%)

Common (1% to 10%): Chest pain, palpitation, vasodilation

Frequency not reported: Angina, atrial fibrillation, congestive heart failure, first degree atrioventricular (AV) block, hypertension, hypotension, jugular venous distension, myocardial infarction, postural hypotension, supraventricular tachycardia, systolic ejection murmur, T wave abnormalities on ECG, T wave flattening, T wave inversion, T wave nonspecific changes, venous insufficiency, ventricular extrasystoles

Postmarketing reports: Chest tightness, tachycardia[Ref]

Nervous system

Very common (10% or more): Headache (up to 22%)

Common (1% to 10%): Dizziness

Frequency not reported: Amnesia, ataxia, cerebral ischemia, cerebrovascular accident, hypertonia, hypoesthesia, migraine, paresthesia, somnolence, syncope, taste disturbance, tremor, vertigo[Ref]

Headache was more commonly reported in elderly patients.[Ref]


Common (1% to 10%): Pharyngitis, sinusitis

Frequency not reported: Asthma, dyspnea, end inspiratory wheeze, epistaxis, fine rales, increased cough, laryngitis, pharyngitis, pleural effusion, rhinitis, sinusitis

Postmarketing reports: Shortness of breath[Ref]


Common (1% to 10%): Rash

Frequency not reported: Acne, alopecia, cellulitis, dry skin, ecchymosis, exfoliative dermatitis, facial edema, fungal dermatitis, herpes simplex, herpes zoster, maculopapular rash, petechia, pruritus, pustular rash, skin discoloration, skin ulcer, sweating, urticaria

Postmarketing reports: Photosensitivity[Ref]


Common (1% to 10%): Nausea

Frequency not reported: Colitis, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastritis, gastrointestinal hemorrhage, gingival hyperplasia, glossitis, melena, mouth ulceration[Ref]


Frequency not reported: Abnormal vision, amblyopia, blepharitis, conjunctivitis, glaucoma, itchy eyes, keratoconjunctivitis, retinal detachment, temporary unilateral vision loss, vitreous floater, watery eyes[Ref]


Frequency not reported: Anorexia, diabetes mellitus, gout, hypokalemia, increased appetite, increased nonprotein nitrogen, increased serum creatine kinase, weight gain, weight loss[Ref]


Frequency not reported: Abnormal dreams, abnormal thinking, anxiety, confusion, decreased libido, depression, insomnia, nervousness[Ref]


Frequency not reported: Arthralgia, arthritis, leg cramps, myalgia, myasthenia, myositis, tenosynovitis[Ref]


Frequency not reported: Dysuria, hematuria, impotence, nocturia, urinary frequency, vaginal hemorrhage, vaginitis[Ref]


Frequency not reported: Chills, ear pain, fever, flu syndrome, malaise, otitis media, tinnitus[Ref]


Frequency not reported: Abnormal liver function tests, hepatomegaly[Ref]


Frequency not reported: Increased blood urea nitrogen, increased serum creatinine[Ref]


Frequency not reported: Anemia, leukopenia[Ref]


Frequency not reported: Thyroiditis

Postmarketing reports: Gynecomastia[Ref]


Postmarketing reports: Angioedema, systemic hypersensitivity reaction[Ref]


1. Product Information. Sular (nisoldipine). Astra-Zeneca Pharmaceuticals. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.