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Sular Side Effects

Generic Name: nisoldipine

Note: This document contains side effect information about nisoldipine. Some of the dosage forms listed on this page may not apply to the brand name Sular.

For the Consumer

Applies to nisoldipine: oral tablet extended release

Along with its needed effects, nisoldipine (the active ingredient contained in Sular) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nisoldipine:

More common
  • Bloating or swelling of face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of hands or feet
  • unusual weight gain or loss
Less common
  • Chest pain
  • dizziness, lightheadedness, or fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth or heat
  • flushing or redness of skin, especially on face and neck
  • headache
  • rash
  • sweating
  • Chest tightness
  • shortness of breath
  • swelling of the arms, face, legs, lips, tongue, or throat

Some side effects of nisoldipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Body aches or pain
  • congestion
  • cough
  • dryness or soreness of throat
  • fever
  • heartbeat sensations
  • hoarseness
  • pain or tenderness around eyes and cheekbones
  • runny nose
  • stuffy nose
  • tender, swollen glands in neck
  • trouble in swallowing
  • voice changes

For Healthcare Professionals

Applies to nisoldipine: oral tablet extended release


The most commonly reported side effects included peripheral edema, headache, dizziness, and pharyngitis.[Ref]


Peripheral edema occurred as a dose-related event, with the highest frequency (27%) reported in patients receiving doses of 34 mg/day.

Peripheral edema and vasodilation were more commonly reported in white patients.[Ref]

Very common (10% or more): Peripheral edema (up to 22%)
Common (1% to 10%): Chest pain, palpitation, vasodilation
Frequency not reported: Angina, atrial fibrillation, congestive heart failure, first degree atrioventricular (AV) block, hypertension, hypotension, jugular venous distension, myocardial infarction, postural hypotension, supraventricular tachycardia, systolic ejection murmur, T wave abnormalities on ECG, T wave flattening, T wave inversion, T wave nonspecific changes, venous insufficiency, ventricular extrasystoles
Postmarketing reports: Chest tightness, tachycardia[Ref]

Nervous system

Very common (10% or more): Headache (up to 22%)
Common (1% to 10%): Dizziness
Frequency not reported: Amnesia, ataxia, cerebral ischemia, cerebrovascular accident, hypertonia, hypoesthesia, migraine, paresthesia, somnolence, syncope, taste disturbance, tremor, vertigo[Ref]

Headache was more commonly reported in elderly patients.[Ref]


Common (1% to 10%): Pharyngitis, sinusitis
Frequency not reported: Asthma, dyspnea, end inspiratory wheeze, epistaxis, fine rales, increased cough, laryngitis, pharyngitis, pleural effusion, rhinitis, sinusitis
Postmarketing reports: Shortness of breath[Ref]


Common (1% to 10%): Rash
Frequency not reported: Acne, alopecia, cellulitis, dry skin, ecchymosis, exfoliative dermatitis, facial edema, fungal dermatitis, herpes simplex, herpes zoster, maculopapular rash, petechia, pruritus, pustular rash, skin discoloration, skin ulcer, sweating, urticaria
Postmarketing reports: Photosensitivity[Ref]


Common (1% to 10%): Nausea
Frequency not reported: Colitis, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastritis, gastrointestinal hemorrhage, gingival hyperplasia, glossitis, melena, mouth ulceration[Ref]


Frequency not reported: Abnormal vision, amblyopia, blepharitis, conjunctivitis, glaucoma, itchy eyes, keratoconjunctivitis, retinal detachment, temporary unilateral vision loss, vitreous floater, watery eyes[Ref]


Frequency not reported: Anorexia, diabetes mellitus, gout, hypokalemia, increased appetite, increased nonprotein nitrogen, increased serum creatine kinase, weight gain, weight loss[Ref]


Frequency not reported: Abnormal dreams, abnormal thinking, anxiety, confusion, decreased libido, depression, insomnia, nervousness[Ref]


Frequency not reported: Arthralgia, arthritis, leg cramps, myalgia, myasthenia, myositis, tenosynovitis[Ref]


Frequency not reported: Dysuria, hematuria, impotence, nocturia, urinary frequency, vaginal hemorrhage, vaginitis[Ref]


Frequency not reported: Chills, ear pain, fever, flu syndrome, malaise, otitis media, tinnitus[Ref]


Frequency not reported: Abnormal liver function tests, hepatomegaly[Ref]


Frequency not reported: Increased blood urea nitrogen, increased serum creatinine[Ref]


Frequency not reported: Anemia, leukopenia[Ref]


Frequency not reported: Thyroiditis
Postmarketing reports: Gynecomastia[Ref]


Postmarketing reports: Angioedema, systemic hypersensitivity reaction[Ref]


1. "Product Information. Sular (nisoldipine)." Zeneca Pharmaceuticals, Wilmington, DE.

Some side effects of Sular may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.