Sular Side Effects
Generic name: nisoldipine
Medically reviewed by Drugs.com. Last updated on May 11, 2024.
Note: This document provides detailed information about Sular.
Applies to nisoldipine: oral tablet extended release Side Effects associated with nisoldipine. Some dosage forms listed on this page may not apply specifically to the brand name Sular.
Applies to nisoldipine: oral tablet extended release.
Precautions
It is important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects .
It is very important that your doctor check your blood regularly while you are taking this medicine. You may also need to monitor your blood pressure at home. If you notice any changes to your recommended blood pressure, call your doctor right away .
Low blood pressure (hypotension) may occur while taking this medicine. Check with your doctor right away if you have the following symptoms: blurred vision; confusion; severe dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; or unusual tiredness or weakness .
This medicine may cause dizziness, lightheadedness, or fainting. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you experience these effects.
Nisoldipine should not be taken with a high-fat meal or with grapefruit juice or other grapefruit products because these may increase the levels of nisoldipine (the active ingredient contained in Sular) in the body .
Serious side effects of Sular
Along with its needed effects, nisoldipine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking nisoldipine:
More common side effects
- bloating or swelling of face, arms, hands, lower legs, or feet
- rapid weight gain
- tingling of hands or feet
- unusual weight gain or loss
Less common side effects
- chest pain
- dizziness, lightheadedness, or fainting
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling of warmth or heat
- flushing or redness of skin, especially on face and neck
- headache
- rash
- sweating
Rare side effects
- chest tightness
- shortness of breath
- swelling of the arms, face, legs, lips, tongue, or throat
Other side effects of Sular
Some side effects of nisoldipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- body aches or pain
- congestion
- cough
- dryness or soreness of throat
- fever
- heartbeat sensations
- hoarseness
- pain or tenderness around eyes and cheekbones
- runny nose
- stuffy nose
- tender, swollen glands in neck
- trouble in swallowing
- voice changes
For healthcare professionals
Applies to nisoldipine: oral tablet extended release.
General adverse events
The most commonly reported side effects included peripheral edema, headache, dizziness, and pharyngitis.[Ref]
Cardiovascular
- Very common (10% or more): Peripheral edema (up to 22%)
- Common (1% to 10%): Chest pain, palpitation, vasodilation
- Frequency not reported: Angina, atrial fibrillation, congestive heart failure, first degree atrioventricular (AV) block, hypertension, hypotension, jugular venous distension, myocardial infarction, postural hypotension, supraventricular tachycardia, systolic ejection murmur, T wave abnormalities on ECG, T wave flattening, T wave inversion, T wave nonspecific changes, venous insufficiency, ventricular extrasystoles
- Postmarketing reports: Chest tightness, tachycardia[Ref]
Peripheral edema occurred as a dose-related event, with the highest frequency (27%) reported in patients receiving doses of 34 mg/day.
Peripheral edema and vasodilation were more commonly reported in white patients.[Ref]
Nervous system
- Very common (10% or more): Headache (up to 22%)
- Common (1% to 10%): Dizziness
- Frequency not reported: Amnesia, ataxia, cerebral ischemia, cerebrovascular accident, hypertonia, hypoesthesia, migraine, paresthesia, somnolence, syncope, taste disturbance, tremor, vertigo[Ref]
Headache was more commonly reported in elderly patients.[Ref]
Respiratory
- Common (1% to 10%): Pharyngitis, sinusitis
- Frequency not reported: Asthma, dyspnea, end inspiratory wheeze, epistaxis, fine rales, increased cough, laryngitis, pharyngitis, pleural effusion, rhinitis, sinusitis
- Postmarketing reports: Shortness of breath[Ref]
Dermatologic
- Common (1% to 10%): Rash
- Frequency not reported: Acne, alopecia, cellulitis, dry skin, ecchymosis, exfoliative dermatitis, facial edema, fungal dermatitis, herpes simplex, herpes zoster, maculopapular rash, petechia, pruritus, pustular rash, skin discoloration, skin ulcer, sweating, urticaria
- Postmarketing reports: Photosensitivity[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea
- Frequency not reported: Colitis, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastritis, gastrointestinal hemorrhage, gingival hyperplasia, glossitis, melena, mouth ulceration[Ref]
Ocular
- Frequency not reported: Abnormal vision, amblyopia, blepharitis, conjunctivitis, glaucoma, itchy eyes, keratoconjunctivitis, retinal detachment, temporary unilateral vision loss, vitreous floater, watery eyes[Ref]
Metabolic
- Frequency not reported: Anorexia, diabetes mellitus, gout, hypokalemia, increased appetite, increased nonprotein nitrogen, increased serum creatine kinase, weight gain, weight loss[Ref]
Psychiatric
- Frequency not reported: Abnormal dreams, abnormal thinking, anxiety, confusion, decreased libido, depression, insomnia, nervousness[Ref]
Musculoskeletal
- Frequency not reported: Arthralgia, arthritis, leg cramps, myalgia, myasthenia, myositis, tenosynovitis[Ref]
Genitourinary
- Frequency not reported: Dysuria, hematuria, impotence, nocturia, urinary frequency, vaginal hemorrhage, vaginitis[Ref]
Other
- Frequency not reported: Chills, ear pain, fever, flu syndrome, malaise, otitis media, tinnitus[Ref]
Hepatic
- Frequency not reported: Abnormal liver function tests, hepatomegaly[Ref]
Renal
- Frequency not reported: Increased blood urea nitrogen, increased serum creatinine[Ref]
Hematologic
- Frequency not reported: Anemia, leukopenia[Ref]
Endocrine
- Frequency not reported: Thyroiditis
- Postmarketing reports: Gynecomastia[Ref]
Hypersensitivity
- Postmarketing reports: Angioedema, systemic hypersensitivity reaction[Ref]
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References
1. (2001) "Product Information. Sular (nisoldipine)." Astra-Zeneca Pharmaceuticals
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Further information
Sular side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.