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Stiolto Respimat Side Effects

Generic Name: olodaterol / tiotropium

Note: This document contains side effect information about olodaterol / tiotropium. Some of the dosage forms listed on this page may not apply to the brand name Stiolto Respimat.

For the Consumer

Applies to olodaterol / tiotropium: inhalation spray

Along with its needed effects, olodaterol/tiotropium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olodaterol / tiotropium:

Less common or rare

  • Bladder pain
  • blindness
  • bloody or cloudy urine
  • blurred vision
  • confusion
  • decrease in the frequency of urination
  • decrease in urine volume
  • decreased urination
  • decreased vision
  • difficult, burning, or painful urination
  • difficulty in passing urine (dribbling)
  • dizziness
  • dry mouth
  • eye pain
  • fainting
  • fast or irregular heartbeat
  • fever
  • frequent urge to urinate
  • headache
  • hives, itching, or rash
  • hoarseness
  • increase in heart rate
  • irritation
  • joint pain, stiffness, or swelling
  • lightheadedness
  • lower back or side pain
  • nausea or vomiting
  • nervousness
  • pounding in the ears
  • rapid breathing
  • redness of the skin
  • slow or fast heartbeat
  • sunken eyes
  • swelling of the eyelids, face, lips, hands, or feet
  • tearing
  • thirst
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness
  • wrinkled skin

Incidence Not Known

  • Cough
  • eye pain or discomfort
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • visual halos or colored images

Some side effects of olodaterol / tiotropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

Less common or rare

  • Bleeding gums
  • bloody nose
  • creamy white, curd-like patches in the mouth or throat
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dry skin
  • heartburn
  • irritation in the mouth
  • mouth ulcers
  • muscle pain or stiffness
  • pain in the joints
  • pain or tenderness around the eyes and cheekbones
  • pain when eating or swallowing
  • redness and swelling of the gums
  • redness, swelling, or soreness of the tongue
  • swelling or inflammation of the mouth
  • trouble sleeping
  • voice changes

For Healthcare Professionals

Applies to olodaterol / tiotropium: inhalation aerosol

General

The most common serious adverse reactions were COPD exacerbation and pneumonia.[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, cough, epistaxis, pharyngitis, dysphonia, bronchospasm, laryngitis, sinusitis[Ref]

Cardiovascular

Common (1% to 10%): Atrial fibrillation, palpitations, supraventricular tachycardia[Ref]

Dermatologic

Common (1% to 10%): Rash, pruritus, angioneurotic edema, urticaria, skin infection, and skin ulcer, dry skin[Ref]

Gastrointestinal

Common (1% to 10%): Dry mouth, constipation, oropharyngeal candidiasis, dysphagia, gastroesophageal reflux disease, gingivitis, glossitis, stomatitis, intestinal obstruction including ileus paralytic[Ref]

Genitourinary

Common (1% to 10%): Urinary retention, dysuria, urinary tract infection

Hypersensitivity

Common (1% to 10%): Immediate hypersensitivity reactions[Ref]

Metabolic

Common (1% to 10%): Dehydration[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia, joint swelling[Ref]

Nervous system

Common (1% to 10%): Dizziness, insomnia[Ref]

Ocular

Common (1% to 10%): Glaucoma, increased intraocular pressure, blurred vision[Ref]

References

1. "Product Information. Stiolto Respimat (olodaterol-tiotropium)." Boehringer Ingelheim, Ridgefield, CT.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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