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Olodaterol and tiotropium

Generic Name: olodaterol and tiotropium (OH loe DAT er ol and TYE oh TROE pee um)
Brand Name: Stiolto Respimat 28 ACT, Stiolto Respimat 60 ACT

Medically reviewed by Drugs.com on Nov 9, 2018 – Written by Cerner Multum

What is olodaterol and tiotropium?

See also: Stiolto

Olodaterol and tiotropium is a combination medicine used to prevent airflow obstruction or bronchospasm in people with COPD (chronic obstructive pulmonary disease). Olodaterol and tiotropium will not treat a bronchospasm attack that has already begun.

Olodaterol and tiotropium is for use only in people with COPD and should not be used to treat asthma.

Olodaterol and tiotropium may also be used for purposes not listed in this medication guide.

Important Information

Olodaterol and tiotropium is for use only in people with chronic obstructive pulmonary disease (COPD) and should not be used to treat asthma.

Olodaterol and tiotropium may increase the risk of death or hospitalization in people with asthma, but the risk in people with COPD is not known.

Call your doctor at once if you have new or worsening COPD symptoms.

Before taking this medicine

You should not use olodaterol and tiotropium if you are allergic to olodaterol, tiotropium, or ipratropium (Atrovent, Combivent, DuoNeb).

Olodaterol and tiotropium may increase the risk of death or hospitalization in people with asthma, but the risk in people with COPD is not known. Talk with your doctor about your own risk.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breast-feeding.

Olodaterol and tiotropium is not approved for use by anyone younger than 18 years old.

How should I use olodaterol and tiotropium?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

The usual dose of this medicine is 2 inhalations once per day. Use the medicine at the same time each day, and not more than once in a 24-hour period. Using too much of this medicine can cause life-threatening side effects.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use only the inhaler device provided with your medicine or you may not get the correct dose. Use the new inhaler each time you get your prescription refilled.

Olodaterol and tiotropium is not a rescue medicine for bronchospasm attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

Store at room temperature. Do not allow the medicine to freeze.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Do not use more than two inhalations every 24 hours.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using olodaterol and tiotropium?

Avoid getting olodaterol and tiotropium in your eyes.

Do not use a second inhaled bronchodilator unless your doctor tells you to. This includes albuterol (Combivent, DuoNeb), arformoterol (Brovana), formoterol (Perforomist, Symbicort, Bevespi, Dulera), indacaterol (Arcapta), olodaterol (Striverdi), salmeterol (Serevent), or vilanterol (Breo Ellipta).

This medicine may cause dizziness and blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Olodaterol and tiotropium side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • wheezing, choking, or other breathing problems after using this medicine;

  • new or worsening COPD symptoms, sudden shortness of breath;

  • painful or difficult urination;

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;

  • severe headache, pounding in your neck or ears;

  • chest pain, fast or pounding heartbeats, fluttering in your chest;

  • high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor; or

  • low potassium--leg cramps, constipation, irregular heartbeats, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Olodaterol and tiotropium dosing information

Usual Adult Dose for Chronic Obstructive Pulmonary Disease -- Maintenance:

-2 inhalations orally once a day, at the same time
Maximum dose: 2 inhalations every 24 hours

Use: Long-term treatment of airflow obstruction in patients with COPD, including chronic bronchitis and/or emphysema

What other drugs will affect olodaterol and tiotropium?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect olodaterol and tiotropium, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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