Olodaterol / Tiotropium Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 3, 2025.

Applies to olodaterol / tiotropium: inhalation spray.

Precautions

It is very important that your doctor check your progress closely while you are using this medicine to see if it is working properly. Blood and urine tests may be needed to check for unwanted effects.

Tell your doctor if you are also using any other medicine for your COPD. Your doctor may want you to use it only during a severe COPD attack. Follow your doctor's instructions on how you should take your medicine.

This medicine should not be used if you are having a severe asthma or COPD attack, or if symptoms of an asthma or COPD attack has already started. Your doctor may prescribe another medicine for you to use in case of an acute COPD attack. If the other medicine does not work as well, tell your doctor right away.

Talk with your doctor or get medical care right away if:

• Your symptoms do not improve after using this medicine or if they become worse.
• Your short-acting inhaler does not seem to work as well as it used to and you need it more often than normal.
• You have a big decrease in your peak flow when measured as directed by your doctor.

This medicine may increase the risk of worsening asthma, which may lead to hospitalization, intubation, and death in patients with asthma who take this medicine without an inhaled steroid medicine. Talk to your doctor if you have concerns about this.

This medicine may cause allergic reactions, including anaphylaxis and angioedema. Check with your doctor right away if you develop a skin rash, itching, trouble breathing, or large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals after using this medicine.

This medicine may cause paradoxical bronchospasm, which means your breathing or wheezing will get worse. Paradoxical bronchospasm may be life-threatening. Check with your doctor right away if you have coughing or difficulty breathing after using this medicine.

This medicine may cause heart or blood vessel problems, including heart rhythm problems. Check with your doctor right away if you have chest pain or tightness, decreased urine output, dilated neck veins, extreme fatigue, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, troubled breathing, or weight gain.

Check with your doctor right away if you have any changes to your eyes, such as eye pain, eye discomfort, blurred vision, visual halos, or colored images with red eyes while you are using this medicine. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).

Check with your doctor right away if you have decrease in urine volume, decrease in the frequency of urination, difficulty in passing urine, or painful urination.

Hypokalemia (low potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have more than one of the following symptoms: convulsions, decreased urine, dry mouth, increased thirst, irregular heartbeat, loss of appetite, mood changes, muscle pain or cramps, nausea or vomiting, numbness or tingling in the hands, feet, or lips, or unusual tiredness or weakness.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines, and herbal or vitamin supplements.

Serious side effects

Along with its needed effects, olodaterol/tiotropium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olodaterol / tiotropium:

Other side effects

Some side effects of olodaterol / tiotropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to olodaterol / tiotropium: inhalation aerosol.

General adverse events

The most common serious adverse reactions were COPD exacerbation and pneumonia.^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, cough, epistaxis, pharyngitis, dysphonia, bronchospasm, laryngitis, sinusitis^[Ref]

Cardiovascular

• Common (1% to 10%): Atrial fibrillation, palpitations, supraventricular tachycardia^[Ref]

Dermatologic

• Common (1% to 10%): Rash, pruritus, angioneurotic edema, urticaria, skin infection, and skin ulcer, dry skin^[Ref]

Gastrointestinal

• Common (1% to 10%): Dry mouth, constipation, oropharyngeal candidiasis, dysphagia, gastroesophageal reflux disease, gingivitis, glossitis, stomatitis, intestinal obstruction including ileus paralytic^[Ref]

Genitourinary

• Common (1% to 10%): Urinary retention, dysuria, urinary tract infection

Hypersensitivity

• Common (1% to 10%): Immediate hypersensitivity reactions^[Ref]

Metabolic

• Common (1% to 10%): Dehydration^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, arthralgia, joint swelling^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, insomnia^[Ref]

Ocular

• Common (1% to 10%): Glaucoma, increased intraocular pressure, blurred vision^[Ref]

See also:

Further information

Olodaterol/tiotropium side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer