Spectrobid Side Effects
Generic name: bacampicillin
Medically reviewed by Drugs.com. Last updated on Aug 25, 2022.
Note: This document contains side effect information about bacampicillin. Some dosage forms listed on this page may not apply to the brand name Spectrobid.
Applies to bacampicillin: oral tablet.
Besides the urticarial rash of hypersensitivity to bacampicillin (the active ingredient contained in Spectrobid) a delayed hypersensitivity maculopapular rash may occur 10 to 12 days after bacampicillin therapy is begun.
Hypersensitivity reactions occur in up to 5% of patients treated with bacampicillin. Such reactions may include urticarial rashes, edema, hypotension, fever, eosinophilia, Stevens-Johnson syndrome, and dyspnea. Anaphylaxis is rare. Bacampicillin should not be given to patients with a penicillin allergy.[Ref]
Gastrointestinal adverse effects occur in 2% to 5% of treated patients and may include diarrhea, nausea, vomiting, and abdominal cramps. Rare cases of hepatitis and pancreatitis have been reported with ampicillin, the active form of bacampicillin (the active ingredient contained in Spectrobid) Monitoring of liver function tests is recommended in patients with liver dysfunction.[Ref]
Bacampicillin-associated diarrhea is usually self-limited and is likely related to alterations in the intestinal microflora. Such alterations may predispose patients to the development of diarrhea from Clostridium difficile toxin. Rare cases of transiently increased liver function tests and chronic cholestasis associated with ampicillin have been reported.
Acute pancreatitis associated with ampicillin has been reported and confirmed by rechallenge with ampicillin in a patient with no other obvious cause of pancreatitis.[Ref]
Hematologic adverse effects of bacampicillin are rare and include thrombocytopenia, red cell aplasia, and anemia.[Ref]
More about Spectrobid (bacampicillin)
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- Drug class: aminopenicillins
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8. Hughes GS "Ampicillin and hematologic effects." Ann Intern Med 99 (1983): 573
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Some side effects may not be reported. You may report them to the FDA.