Serentil Side Effects
Generic name: mesoridazine
Note: This document provides detailed information about Serentil Side Effects associated with mesoridazine. Some dosage forms listed on this page may not apply specifically to the brand name Serentil.
Applies to mesoridazine: injectable solution, oral concentrate, oral tablet.
Important warnings
This medicine can cause some serious health issues
If you experience any of the following serious side effects, stop taking mesoridazine (the active ingredient contained in Serentil) and seek emergency medical treatment:
-
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
-
uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs;
-
fever;
-
muscle rigidity;
-
muscle spasms of the face or neck;
-
sweating;
-
irregular pulse;
-
fast or irregular heartbeats.
-
severe restlessness or tremor;
-
severe drowsiness;
-
blurred vision;
-
dizziness or fainting; or
-
a rash.
Other, less serious side effects may be more likely to occur. Continue to take mesoridazine and talk to your doctor if you experience:
-
dry mouth or stuffy nose;
-
mild restlessness, drowsiness, or tremor;
-
difficult urination or dark urine;
-
decreased sex drive;
-
increased appetite; or
-
menstrual irregularities or swollen breasts.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
For healthcare professionals
Applies to mesoridazine: injectable solution, oral concentrate, oral tablet.
Cardiovascular adverse events
Cardiovascular side effects including hypotension and tachycardia have been reported. Mesoridazine (the active ingredient contained in Serentil) has also been reported to prolong the QTc interval in a dose related manner.[Ref]
Drugs with the potential to prolong the QTc interval have been associated with torsades de pointes-type arrhythmias and sudden death.[Ref]
Nervous system
Central nervous system side effects including drowsiness, Parkinson's syndrome, dizziness, weakness, tremor, restlessness, ataxia, dystonia, rigidity, slurring, akathisia, and motoric reactions (opisthotonos) have been reported. Autonomic nervous system effects including dry mouth, nausea and vomiting, fainting, stuffy nose, photophobia, constipation, and blurred vision have also been reported.[Ref]
Adverse effects including rigidity and motoric effects tend to occur later in therapy.[Ref]
Genitourinary
Genitourinary side effects including inhibition of ejaculation, impotence, enuresis, incontinence and priapism have been reported.[Ref]
Dermatologic
Dermatologic side effects including itching, rash, hypertrophic papillae of the tongue, and angioneurotic edema have been reported.[Ref]
References
1. (2001) "Product Information. Serentil (mesoridazine)." Boehringer-Ingelheim
2. Starck LC, Talley BJ, Brannan SK (1994) "Mesoridazine use and priapism [letter]." Am J Psychiatry, 151, p. 946
3. Compton MT, Miller AH (2001) "Priapism associated with conventional and atypical antipsychotic medications: A review." J Clin Psychiatry, 62, p. 362-6
More about Serentil (mesoridazine)
- Check interactions
- Compare alternatives
- Drug images
- Dosage information
- During pregnancy
- Drug class: phenothiazine antipsychotics
- Breastfeeding
Professional resources
Related treatment guides
Further information
Serentil side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.