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Serentil Side Effects

Generic Name: mesoridazine

Note: This page contains side effects data for the generic drug mesoridazine. It is possible that some of the dosage forms included below may not apply to the brand name Serentil.

Applies to mesoridazine: injectable solution, oral concentrate, oral tablet


Drugs with the potential to prolong the QTc interval have been associated with torsades de pointes-type arrhythmias and sudden death.[Ref]

Cardiovascular side effects including hypotension and tachycardia have been reported. Mesoridazine has also been reported to prolong the QTc interval in a dose related manner.[Ref]

Nervous system

Central nervous system side effects including drowsiness, Parkinson's syndrome, dizziness, weakness, tremor, restlessness, ataxia, dystonia, rigidity, slurring, akathisia, and motoric reactions (opisthotonos) have been reported. Autonomic nervous system effects including dry mouth, nausea and vomiting, fainting, stuffy nose, photophobia, constipation, and blurred vision have also been reported.[Ref]

Adverse effects including rigidity and motoric effects tend to occur later in therapy.[Ref]


Genitourinary side effects including inhibition of ejaculation, impotence, enuresis, incontinence and priapism have been reported.[Ref]


Dermatologic side effects including itching, rash, hypertrophic papillae of the tongue, and angioneurotic edema have been reported.[Ref]


1. "Product Information. Serentil (mesoridazine)" Boehringer-Ingelheim, Ridgefield, CT.

2. Starck LC, Talley BJ, Brannan SK "Mesoridazine use and priapism [letter]." Am J Psychiatry 151 (1994): 946

3. Compton MT, Miller AH "Priapism associated with conventional and atypical antipsychotic medications: A review." J Clin Psychiatry 62 (2001): 362-6

It is possible that some side effects of Serentil may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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