Skip to main content

Semprex-D Side Effects

Generic name: acrivastine / pseudoephedrine

Medically reviewed by Last updated on Jul 30, 2022.

Note: This document contains side effect information about acrivastine / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name Semprex-D.


Common side effects of Semprex-D include: dizziness and drowsiness. Other side effects include: insomnia, sedated state, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to acrivastine/pseudoephedrine: oral capsule

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad dizziness or passing out.
  • A fast heartbeat.
  • A heartbeat that does not feel normal.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling nervous and excitable.
  • Not able to sleep.
  • Feeling sleepy.
  • Headache.
  • Dry mouth.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to acrivastine / pseudoephedrine: oral capsule

Nervous system

Very common (10% or more): Headache (19%), somnolence (12%)

Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%): Dry mouth, nausea, dyspepsia[Ref]


Postmarketing reports: Serious hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, erythema multiforme)[Ref]


Common (1% to 10%): Insomnia, nervousness


Common (1% to 10%): Dysmenorrhea


Common (1% to 10%): Pharyngitis, cough increase


Common (1% to 10%): Asthenia

More about Semprex-D (acrivastine / pseudoephedrine)

Patient resources

Professional resources

Related treatment guides


1. "Product Information. Semprex-D (acrivastine-pseudoephedrine)." Endo Laboratories LLC (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.