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Semprex-D Side Effects

Generic Name: acrivastine / pseudoephedrine

Medically reviewed by Last updated on June 25, 2020.

Note: This document contains side effect information about acrivastine / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name Semprex-D.

In Summary

Common side effects of Semprex-D include: dizziness and drowsiness. Other side effects include: insomnia, sedated state, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to acrivastine/pseudoephedrine: oral capsule

Side effects requiring immediate medical attention

Along with its needed effects, acrivastine / pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Get emergency help immediately if any of the following symptoms of overdose occur while taking acrivastine / pseudoephedrine:

Symptoms of overdose

  • Blurred vision
  • chest pain or discomfort
  • cold, clammy, or pale skin
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • irregular heartbeats
  • seizures
  • shortness of breath
  • slow heart rate
  • sweating
  • unusual tiredness or weakness

Side effects not requiring immediate medical attention

Some side effects of acrivastine / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dry mouth
  • headache
  • sleepiness or unusual drowsiness

Less common

  • Acid or sour stomach
  • belching
  • body aches or pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • heartburn
  • hoarseness
  • indigestion
  • lack or loss of strength
  • nausea
  • nervousness
  • runny nose
  • stomach discomfort, upset, or pain
  • tender, swollen glands in the neck
  • trouble sleeping
  • trouble swallowing
  • voice changes

For Healthcare Professionals

Applies to acrivastine / pseudoephedrine: oral capsule

Nervous system

Very common (10% or more): Headache (19%), somnolence (12%)

Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%): Dry mouth, nausea, dyspepsia[Ref]


Postmarketing reports: Serious hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, erythema multiforme)[Ref]


Common (1% to 10%): Insomnia, nervousness


Common (1% to 10%): Dysmenorrhea


Common (1% to 10%): Pharyngitis, cough increase


Common (1% to 10%): Asthenia


1. "Product Information. Semprex-D (acrivastine-pseudoephedrine)." Endo Laboratories LLC, Chadds Ford, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.