Semprex-D Side Effects
Generic Name: acrivastine / pseudoephedrine
Note: This page contains side effects data for the generic drug acrivastine / pseudoephedrine. It is possible that some of the dosage forms included below may not apply to the brand name Semprex-D.
Common side effects of Semprex-D include: dizziness and drowsiness. Other side effects include: insomnia, sedation, and xerostomia. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to acrivastine / pseudoephedrine: oral capsule
As well as its needed effects, acrivastine / pseudoephedrine may cause unwanted side effects that require medical attention.
If any of the following symptoms of overdose occur while taking acrivastine / pseudoephedrine, get emergency help immediately:Symptoms of overdose:
- Blurred vision
- chest pain or discomfort
- cold, clammy, or pale skin
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- irregular heartbeats
- shortness of breath
- slow heart rate
- unusual tiredness or weakness
Minor Side Effects
Some acrivastine / pseudoephedrine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- Dry mouth
- sleepiness or unusual drowsiness
- Acid or sour stomach
- body aches or pain
- dryness or soreness of the throat
- lack or loss of strength
- runny nose
- stomach discomfort, upset, or pain
- tender, swollen glands in the neck
- trouble sleeping
- trouble swallowing
- voice changes
For Healthcare Professionals
Applies to acrivastine / pseudoephedrine: oral capsule
Although acrivastine has little effect on the central nervous system, a reduction in motor skills when taken with alcohol has been seen in at least one study. Patients should be warned not to take acrivastine with alcohol or other sedating drugs.[Ref]
Nervous system side effects of pseudoephedrine have included stimulation, resulting in tremor, anxiety, and nervousness. Insomnia has been reported in up to 30% of pseudoephedrine-treated patients. Headache has also been reported.
Nervous system side effects of acrivastine have included uncommon reports of sedation especially when given in combination with pseudoephedrine. Acrivastine has caused more sedation than placebo, but less than other antihistamines with sedating qualities. Acrivastine has also rarely caused headache, somnolence, and dizziness.[Ref]
Cardiovascular side effects of pseudoephedrine have included significant increases in heart rate. Hypertension and arrhythmias may be problematic in susceptible patients.[Ref]
Pseudoephedrine causes vasoconstriction which generally does not produce hypertension, but may be problematic for patients with preexisting hypertension. Arrhythmias may be produced in predisposed patients. Rarely, pseudoephedrine has been reported to cause coronary artery spasm and chest pain.[Ref]
Gastrointestinal side effects of pseudoephedrine have included anorexia and gastric irritation in approximately 5% of patients. Dry mouth, nose, or throat has occurred in up to 15% of patients.
Gastrointestinal side effects of acrivastine have included dry mouth, and rarely, nausea.[Ref]
Hypersensitivity side effects of pseudoephedrine have included reports of fixed drug eruptions.
Hypersensitivity side effects of acrivastine have included rare reports of reactions.[Ref]
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15. Rosen RA "Angina associated with pseudoephedrine ." Ann Emerg Med 10 (1981): 230-1
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18. Tomb RR, Lepoittevin JP, Espinassouze F, Heid E, Foussereau J "Systemic contact dermatitis from pseudoephedrine." Contact Dermatitis 24 (1991): 86-8
19. Camisa C "Fixed drug eruption due to pseudoephedrine." Cutis 41 (1988): 339-40
20. Quan MB, Chow WC "Nonpigmenting fixed drug eruption after pseudoephedrine." Int J Dermatol 35 (1996): 367-70
21. Shelley WB, Shelley ED "Nonpigmenting fixed drug eruption as a distinctive reaction pattern: examples caused by sensitivity to pseudoephedrine hydrochloride and tetrahydrozoline." J Am Acad Dermatol 17 (1987): 403-7
It is possible that some side effects of Semprex-D may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
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