Sanctura XR Side Effects

Generic name: trospium

Medically reviewed by Drugs.com. Last updated on Apr 17, 2025.

Note: This document provides detailed information about Sanctura XR.

Applies to trospium: oral capsule extended release, oral tablet Side Effects associated with trospium. Some dosage forms listed on this page may not apply specifically to the brand name Sanctura XR.

Applies to trospium: oral capsule extended release, oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

This medicine may cause a serious type of allergic reaction called angioedema. Angioedema may be life-threatening and requires immediate medical attention. Stop taking trospium (the active ingredient contained in Sanctura XR) and check with your doctor right away if you have a rash, itching, a large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, trouble breathing, or chest tightness while you are using this medicine.

This medicine, especially in high doses, may cause some people to become dizzy, drowsy, confused, or have blurred vision. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy, not alert, or not able to see well. Drinking alcohol with this medicine may increase your risk of having drowsiness.

This medicine may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine, since overheating may result in heat stroke.

This medicine may cause a dry mouth, nose, and throat. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. If your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Sanctura XR

Along with its needed effects, trospium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trospium:

Other side effects of Sanctura XR

Some side effects of trospium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to trospium: oral capsule extended release, oral tablet.

Cardiovascular adverse events

• Uncommon (0.1% to 1%): Tachycardia, chest pain
• Frequency not reported: Tachyarrhythmia
• Postmarketing reports: Palpitations, supraventricular tachycardia, chest pain, syncope, hypertensive crisis^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain, constipation aggravated, dyspepsia, flatulence, nausea, dyspepsia, abdominal distension
• Uncommon (0.1% to 1%): Abdominal distention, vomiting, dry throat, diarrhea
• Postmarketing reports: Gastritis^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Uncommon (0.1% to 1%): Dysgeusia
• Rare (less than 0.1%): Dizziness^[Ref]

Ocular

• Common (1% to 10%): Dry eyes
• Uncommon (0.1% to 1%): Blurred vision
• Rare (less than 0.1%): Vision disorders
• Postmarketing reports: Vision abnormal^[Ref]

Psychiatric

• Postmarketing reports: Confusion, hallucinations, somnolence, delirium, agitation^[Ref]

Other

• Common (1% to 10%): Fatigue^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Dry skin
• Rare (0.01% to 0.1%): Rash
• Very rare (less than 0.01%): Angioedema
• Frequency not reported: Pruritus, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN)^[Ref]

Hypersensitivity

• Frequency not reported: Anaphylactic reaction^[Ref]

Immunologic

• Common (1% to 10%): Influenza^[Ref]

Musculoskeletal

• Rare (less than 0.1%): Myalgia, arthralgia
• Postmarketing reports: Rhabdomyolysis^[Ref]

Hepatic

• Frequency not reported: Mild to moderate increase in serum transaminase levels^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, nasal dryness
• Frequency not reported: Dyspnea^[Ref]

See also:

Further information

Sanctura XR side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer