Robinul Side Effects

Generic name: glycopyrrolate

Medically reviewed by Drugs.com. Last updated on Mar 24, 2022.

Note: This document contains side effect information about glycopyrrolate. Some of the dosage forms listed on this page may not apply to the brand name Robinul.

For the Consumer

Applies to glycopyrrolate: oral solution, oral tablet, oral tablet disintegrating

Other dosage forms:

Side effects requiring immediate medical attention

Along with its needed effects, glycopyrrolate (the active ingredient contained in Robinul) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glycopyrrolate:

More common

Body aches or pain
chills
constipation
cough
decrease in the frequency of urination
decrease in urine volume
difficulty in passing urine (dribbling)
difficulty with breathing
ear congestion
feeling of warmth
fever
headache
loss of voice
painful urination
redness of the face, neck, arms, and occasionally, upper chest
runny or stuffy nose
sneezing
sore throat
unusual tiredness or weakness

Less common

Chest pain or tightness
confusion
dizziness
dry heaves
dry mouth
fainting
increase in heart rate
lightheadedness
pain or tenderness around the eyes and cheekbones
rapid breathing
stomach pain or discomfort
stuffy nose
sunken eyes
thirst
trouble breathing
vomiting
wrinkled skin

Incidence not known

Change in taste
difficulty swallowing
fast heartbeat
hives, itching, skin rash
loss of taste
pale or blue lips, fingernails, or skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

Get emergency help immediately if any of the following symptoms of overdose occur while taking glycopyrrolate:

Blurred vision
confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
muscle weakness
sweating
trouble breathing
unusual tiredness or weakness

Side effects not requiring immediate medical attention

Some side effects of glycopyrrolate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Altered mood
anxiety
attack, assault, or force
bloated
chapped lips
crying
dry skin
dry tongue
excess air or gas in the stomach or intestines
full feeling
hyperventilation
irregular heartbeats
irritability
moaning
nervousness
pain
paleness of the skin
passing gas
rash
restlessness
shaking
trouble with sleeping
uncontrolled eye movements

Incidence not known

Decreased interest in sexual intercourse
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance

For Healthcare Professionals

Applies to glycopyrrolate: compounding powder, inhalation capsule, inhalation solution, injectable solution, intravenous solution, oral solution, oral tablet, oral tablet disintegrating

Gastrointestinal

Very common (10% or more): Dry mouth (40%), vomiting (40%), constipation (35%)

Frequency not reported: Abdominal distension, abdominal pain, stomach discomfort, chapped lips, flatulence, retching, dry tongue^[Ref]

Cardiovascular

Very common (10% or more): Flushing (30%)

Frequency not reported: Heart rate increase, pallor^[Ref]

Nervous system

Very common (10% or more): Headache (15%)

Frequency not reported: Convulsion, dysgeusia, nystagmus

Postmarketing reports: Loss of taste^[Ref]

Genitourinary

Very common (10% or more): Urinary retention (15%)

Postmarketing reports: Suppression of lactation^[Ref]

Immunologic

Very common (10% or more): Sinusitis (15%), upper respiratory tract infection (15%)

Frequency not reported: Pneumonia, tracheostomy infection, urinary tract infection^[Ref]

Respiratory

Very common (10% or more): Nasal congestion (30%)

Frequency not reported: Increased viscosity of bronchial secretion, nasal dryness^[Ref]

Psychiatric

Frequency not reported: Irritability, agitation, restlessness, abnormal behavior, aggression, crying, impulse control disorder, moaning, mood altered^[Ref]