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Generic Name: glycopyrrolate (oral) (GLY koe PIE roe late)
Brand Names: Cuvposa

Medically reviewed by P. Thornton, DipPharm Last updated on Jul 1, 2019.

What is Cuvposa?

Cuvposa (glycopyrrolate) reduces the secretions of certain organs in the body.

Cuvposa is used to reduce drooling in children ages 3 to 16 who have certain medical conditions, such as cerebral palsy.

Cuvposa may also be used for purposes not listed in this medication guide.

Important Information

You should not use Cuvposa if you have urination problems, a blockage in your stomach or intestines, severe constipation, severe ulcerative colitis or toxic megacolon, glaucoma, myasthenia gravis, or active bleeding with heart and blood circulation problems.

Before you take Cuvposa, tell your doctor if you have kidney disease, heart disease, a heart rhythm disorder, a stomach disorder, a colostomy or ileostomy, a thyroid disorder, high blood pressure, vision problems, or numbness and tingling.

Take Cuvposa on an empty stomach, at least 1 hour before or 2 hours after a meal. This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Drinking alcohol can increase certain side effects of Cuvposa, such as dizziness and drowsiness. Avoid becoming overheated or dehydrated during exercise and in hot weather. Glycopyrrolate can decrease sweating and you may be more prone to heat stroke.

Before taking this medicine

You should not use Cuvposa if you are allergic to glycopyrrolate, or if you have:

To make sure Cuvposa is safe for you, tell your doctor if you have ever had:

  • liver or kidney disease;

  • heart problems or a heart rhythm disorder;

  • high blood pressure;

  • a stomach disorder such as ulcerative colitis, hiatal hernia, reflux disease, or slow digestion;

  • a colostomy or ileostomy;

  • a thyroid disorder; or

  • a nerve disorder.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using Cuvposa. Glycopyrrolate may slow breast milk production.

Do not give this medicine to a child without medical advice.

How should I take Cuvposa?

Take Cuvposa exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may need to take Cuvposa on an empty stomach, at least 1 hour before or 2 hours after a meal. Follow the instructions provided with your medicine.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Glycopyrrolate doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Cuvposa dosing information

Usual Pediatric Dose for Excessive Salivation:

3 years to 16 years with neurologic conditions associated with problem drooling:

Initiate dosing at 0.02 mg/kg orally three times daily and titrate in increments of 0.02 mg/kg every 5 to 7 days, based on therapeutic response and adverse reactions. Maximum recommended dose is 0.1 mg/kg three times daily, not to exceed 1.5 to 3 mg per dose based upon weight. Administer at least one hour before or two hours after meals.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe muscle weakness, loss of movement, dilated pupils, jerky muscle movements, or seizure (convulsions).

What should I avoid while taking Cuvposa?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Glycopyrrolate can decrease sweating and you may be more prone to heat stroke.

Drinking alcohol with this medicine can cause side effects.

Cuvposa side effects

Get emergency medical help if you have signs of an allergic reaction to Cuvposa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Cuvposa and call your doctor at once if you have:

  • severe constipation, severe stomach pain and bloating;

  • diarrhea (especially if you have a colostomy or ileostomy);

  • painful or difficult urination;

  • fast or pounding heartbeats, fluttering in your chest;

  • confusion, severe drowsiness;

  • eye pain, seeing halos around lights;

  • fever, shallow breathing, weak pulse, hot and red skin; or

  • (in a child taking this medicine) dry diapers, fussiness, or excessive crying.

Common Cuvposa side effects may include:

  • constipation, nausea, vomiting, bloating;

  • drowsiness, dizziness, weakness, feeling nervous;

  • slow heartbeats;

  • sleep problems (insomnia);

  • blurred vision, sensitivity to light;

  • dry mouth, decreased sense of taste;

  • decreased sweating, decreased urination;

  • impotence, sexual problems;

  • headache; or

  • rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cuvposa?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with glycopyrrolate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cuvposa only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.