Rezine Side Effects
Generic name: hydroxyzine
Medically reviewed by Drugs.com. Last updated on Apr 26, 2021.
Note: This document contains side effect information about hydroxyzine. Some of the dosage forms listed on this page may not apply to the brand name Rezine.
For the Consumer
Applies to hydroxyzine: oral capsule, oral syrup, oral tablet
Other dosage forms:
Side effects requiring immediate medical attention
Along with its needed effects, hydroxyzine (the active ingredient contained in Rezine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking hydroxyzine:
Incidence not known
- Chest pain or discomfort
- difficulty with swallowing
- fast heartbeat
- hives, itching, or skin rash
- irregular or slow heart rate
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- tightness in the chest
- unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur while taking hydroxyzine:
Symptoms of overdose
Side effects not requiring immediate medical attention
Some side effects of hydroxyzine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Shakiness in the legs, arms, hands, or feet
- trembling or shaking of the hands or feet
Incidence not known
- Dry mouth
- seeing, hearing, or feeling things that are not there
For Healthcare Professionals
Applies to hydroxyzine: compounding powder, intramuscular solution, oral capsule, oral suspension, oral syrup, oral tablet
The most commonly reported side effects included sleepiness, headache, and tiredness.[Ref]
Very common (10% or more): Sleepiness (up to 13.74%)
Common (1% to 10%): Headache
Rare (0.01% to 0.1%): Convulsion, tremor
Frequency not reported: Anticholinergic activity, central nervous system (CNS) depression, drowsiness, incoordination, involuntary motor activity, psychomotor impairment, stimulation
Common (1% to 10%): Tiredness
Frequency not reported: Antimuscarinic effects, lassitude
Postmarketing reports: Asthenia, malaise, pyrexia, sudden death[Ref]
Common (1% to 10%): Dry mouth
Frequency not reported: QT prolongation, Torsade de Pointes
Frequency not reported: Hypersensitivity reaction
Frequency not reported: Respiratory depression
Postmarketing reports: Bronchospasm[Ref]
Postmarketing reports: Acute generalized exanthematous pustulosis (AGEP), bullous condition (pemphigoids, toxic epidermal necrolysis), dermatitis, erythema, erythema multiforme, fixed drug eruptions, increased sweating, maculopapular rash, pruritus, rash, Stevens-Johnson syndrome, urticaria[Ref]
Postmarketing reports: Accommodation disorder, blurred vision, oculogyric crisis[Ref]
Postmarketing reports: Weight gain[Ref]
Frequently asked questions
More about Rezine (hydroxyzine)
Related treatment guides
1. "Product Information. Atarax (hydroxyzine)" Pfizer US Pharmaceuticals, New York, NY.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. "Product Information. Vistaril (hydroxyzine)." Pfizer US Pharmaceuticals, New York, NY.
Some side effects may not be reported. You may report them to the FDA.