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Radium 223 Dichloride Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 31, 2024.

Applies to radium 223 dichloride: intravenous solution.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

This medicine can cause birth defects if the father is using it when his sexual partner becomes pregnant. If you are sexually active with a female who could become pregnant, use a condom during treatment with this medicine and for 6 months after the last dose. Your sexual partner must also use an effective form of birth control during treatment and for 6 months after the last dose. If a pregnancy occurs while you are receiving this medicine, tell your doctor right away.

Xofigo® can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

This medicine may increase your risk for fractures when used with abiraterone (Zytiga®) plus prednisone or prednisolone.

Check with your doctor right away if you have confusion, decrease in the amount of urine, dizziness, dry mouth, fainting, increased heart rate, lightheadedness, rapid breathing, sunken eyes, thirst, or unusual tiredness or weakness. These may be symptoms of dehydration.

Check with your doctor right away if you have bloody urine, decrease in the amount of urine, swelling of the face, fingers, or lower legs, trouble breathing, or weight gain. These could be symptoms of kidney problems.

You will be exposed to radiation with this medicine. Talk to your doctor if you have concerns about this.

Serious side effects

Along with its needed effects, radium 223 dichloride may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking radium 223 dichloride:

More common side effects

  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • chest pain
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tingling of the hands or feet
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common side effects

  • confusion
  • decreased frequency or amount of urine
  • dizziness
  • dry mouth
  • fainting
  • high fever
  • hoarseness
  • increase in heart rate
  • increased blood pressure
  • increased thirst
  • lightheadedness
  • loss of appetite
  • nausea
  • rapid breathing
  • sunken eyes
  • thirst
  • vomiting
  • weight gain
  • wrinkled skin

Other side effects

Some side effects of radium 223 dichloride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

Less common side effects

  • redness, pain, and swelling at the injection site

For healthcare professionals

Applies to radium 223 dichloride: intravenous solution.

General adverse events

The most common side effects (incidence of 10% or greater) were nausea, diarrhea, vomiting, and peripheral edema.

The most common hematologic laboratory abnormalities (incidence of 10% or greater) were anemia, lymphocytopenia, leukopenia, thrombocytopenia, and neutropenia.[Ref]

Hematologic

Gastrointestinal

Local

Other

Renal

See also:

References

1. (2019) "Product Information. Xofigo (radium Ra 223 dichloride)." Bayer Pharmaceutical Inc

Further information

Radium 223 dichloride side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.