Radium 223 Dichloride Dosage

Medically reviewed by Drugs.com. Last updated on Mar 7, 2025.

Usual Adult Dose for:

Prostate Cancer

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Precautions
Dialysis
Other Comments

Usual Adult Dose for Prostate Cancer

55 kilobecquerel (kBq) or 1.49 microcurie, per kg body weight, IV, every 4 weeks

Duration of therapy: 6 doses

Comments: See manufacturer's product information for complete dosing instructions including decay correction factor table and calculation of correct volume for dosing.

Use: The treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases, and no known visceral metastatic disease.

Renal Dose Adjustments

Mild to moderate renal impairment (CrCl 30 to 89 mL/min): No adjustment recommended
Severe renal impairment (CrCl less than 30 mL/min): Data not available

Liver Dose Adjustments

Mild hepatic impairment: No adjustment recommended
Moderate to severe hepatic impairment: Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for dosing related precautions.

Dialysis

Data not available

Other Comments

Administration advice: Administer by slow intravenous injection over 1 minute.

Storage requirements: Store in the original container or equivalent radiation shielding.

Reconstitution/preparation techniques: The manufacturer's product information should be consulted.

General:

Follow procedures for proper handling and disposal of radioactive pharmaceuticals.
This preparation is approved for use only by persons under license by the Nuclear Regulatory Commission or the relevant regulatory authority of an Agreement State.