Proglycem Side Effects
Generic name: diazoxide
Medically reviewed by Drugs.com. Last updated on Apr 5, 2023.
Note: This document contains side effect information about diazoxide. Some dosage forms listed on this page may not apply to the brand name Proglycem.
Applies to diazoxide: oral suspension.
Side effects include:
Sodium and fluid retention, tachycardia, palpitations, increased uric acid concentrations, hyperglycemia or glycosuria, GI intolerance, hirsutism, thrombocytopenia.
For Healthcare Professionals
Applies to diazoxide: compounding powder, injectable solution, oral capsule, oral suspension.
Cardiovascular
Angina with myocardial and cerebral infarction have been associated with the use of a 300 mg intravenous dose of diazoxide (the active ingredient contained in Proglycem)
One case of optic nerve infarction was reported following a single 300 mg bolus dose of diazoxide, as a result of a sudden reduction in diastolic pressure.
Results from one prospective trial conducted in patients with severe hypertension and coronary artery disease showed a 50% incidence of ischemic changes in the electrocardiogram following single 300 mg bolus injections of diazoxide.[Ref]
Common (1% to 10%): Tachycardia, palpitations
Frequency not reported: Hypotension, transient hypertension, chest pain[Ref]
Nervous system
Frequency not reported: Transient loss of taste, headache, dizziness, polyneuritis, paresthesia, extrapyramidal signs[Ref]
Gastrointestinal
Frequency not reported: Nausea, vomiting, abdominal pain, ileus, diarrhea[Ref]
Metabolic
Sodium and fluid retention may precipitate congestive heart failure in patients with compromised cardiac reserve.[Ref]
Common (1% to 10%): Increased levels of serum uric acid
Frequency not reported: Sodium retention, fluid retention, diabetic ketoacidosis, hyperosmolar nonketotic coma, hyperglycemia, glycosuria, anorexia[Ref]
Respiratory
Frequency not reported: Pulmonary hypertension[Ref]
Other
Frequency not reported: Weakness, malaise, fever[Ref]
Hematologic
Frequency not reported: Thrombocytopenia with or without purpura, neutropenia, eosinophilia, decreased hemoglobin/hematocrit, excessive bleeding, azotemia, lymphadenopathy[Ref]
Immunologic
Frequency not reported: Decreased IgG, monilial dermatitis, herpes[Ref]
Musculoskeletal
Frequency not reported: Advance in bone age[Ref]
Ocular
Frequency not reported: Transient cataracts, subconjunctival hemorrhage, ring scotoma, blurred vision, diplopia, lacrimation[Ref]
Psychiatric
Frequency not reported: Anxiety, insomnia[Ref]
Genitourinary
Frequency not reported: Decreased urinary output, hematuria, albuminuria, galactorrhea, enlargement of lump in breast[Ref]
Hepatic
Frequency not reported: Increased AST, increased alkaline phosphatase[Ref]
Renal
Frequency not reported: Decreased creatinine clearance, reversible nephrotic syndrome[Ref]
Dermatologic
Frequency not reported: Hirsutism of lanugo type (mainly on the forehead, back, and limbs), skin rash, pruritus, loss of scalp hair[Ref]
Endocrine
Frequency not reported: Gout, acute pancreatitis/pancreatic necrosis[Ref]
Frequently asked questions
- Should you use a diuretic with diazoxide?
- How does diazoxide (Proglycem) cause hyperglycemia?
- Is diazoxide a vasodilator?
- How does diazoxide slow insulin?
More about Proglycem (diazoxide)
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- Drug class: agents for hypertensive emergencies
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References
1. Product Information. Proglycem (diazoxide). Teva Pharmaceuticals USA. 2015.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.