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Probenecid and Colchicine Side Effects

Generic Name: colchicine / probenecid

Note: This document contains side effect information about colchicine / probenecid. Some of the dosage forms listed on this page may not apply to the brand name Probenecid and Colchicine.

For the Consumer

Applies to colchicine / probenecid: oral tablet

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • A burning, numbness, or tingling feeling that is not normal.
  • Very upset stomach or throwing up.
  • Very loose stools (diarrhea).
  • Back pain, belly pain, or blood in the urine. May be signs of a kidney stone.
  • Not able to pass urine or change in how much urine is passed.
  • Any unexplained bruising or bleeding.
  • Feeling very tired or weak.
  • Pale skin.
  • Very bad muscle problems may happen with this drug. This can also lead to kidney problems. Tell your doctor if you have muscle pain or weakness, mainly if you feel very tired or weak or have a fever. Tell your doctor if you are unable to pass urine or you have a change in how much urine is passed.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Headache.
  • Flushing.
  • Loose stools (diarrhea).
  • Not hungry.
  • Upset stomach or throwing up.
  • Hair loss.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to colchicine / probenecid: oral tablet

Nervous system

Probenecid:
Frequency not reported: Headache, dizziness

Colchicine:
Frequency not reported: Peripheral neuritis[Ref]

Gastrointestinal

Probenecid:
Frequency not reported: Nausea, vomiting, abdominal pain, anorexia, sore gums

Colchicine:
Frequency not reported: Nausea, vomiting, abdominal pain, or diarrhea (may be particularly troublesome in the presence of peptic ulcer or spastic colon)[Ref]

Renal

Probenecid:
Frequency not reported: Nephrotic syndrome, renal colic

Colchicine:
Frequency not reported: Renal damage with hematuria and oliguria have occurred with toxic doses

Hematologic

Probenecid:
Frequency not reported: Leukopenia, aplastic anemia, hemolytic anemia (may be due to genetic deficiency of glucose 6 phosphate dehydrogenase) and anemia

Colchicine:
Frequency not reported: Thrombocytopenia, pancytopenia, leukopenia, agranulocytosis, bone marrow failure, disseminated intravascular coagulation, aplastic anemia[Ref]

Hepatic

Probenecid:
Frequency not reported: Hepatic necrosis.

Hypersensitivity

Probenecid:
Frequency not reported: Anaphylaxis, fever, urticaria, pruritus

Colchicine:
Frequency not reported: Urticaria[Ref]

Dermatologic

Probenecid:
Frequency not reported: Dermatitis, alopecia, flushing

Colchicine:
Frequency not reported: Dermatitis, purpura, alopecia[Ref]

Metabolic

Probenecid:
Frequency not reported: Precipitation of acute gouty arthritis[Ref]

Musculoskeletal

Colchicine:
Frequency not reported: Muscular weakness[Ref]

Genitourinary

Probenecid:
Frequency not reported: Urinary frequency, azoospermia, uric acid stones with or without hematuria, costovertebral pain[Ref]

Other

At toxic doses, other side effects associated with colchicine have included severe diarrhea, generalized vascular damage, and renal damage with hematuria and oliguria.[Ref]

References

1. "Product Information. Colchicine-Probenecid (colchicine-probenecid)." Watson Pharmaceuticals, Corona, CA.

Some side effects of Probenecid and Colchicine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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