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Colchicine and probenecid

Generic name: colchicine and probenecid [ KOL-chi-seen-and-pro-BEN-e-sid ]
Dosage form: oral tablet (0.5 mg-500 mg)
Drug class: Antigout agents

Medically reviewed by on Aug 25, 2022. Written by Cerner Multum.

What is colchicine and probenecid?

Colchicine alters the way your body responds to uric acid crystals. Too much uric acid in the body is what leads to the symptoms of gout (swelling and pain).

Probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

Colchicine and probenecid is a combination medicine used to prevent gout attacks. This medication will not cure gout and it will not stop a gout attack that has already started.

Colchicine and probenecid may also be used for purposes not listed in this medication guide.


This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Take all of your gout medications as directed.

Before taking this medicine

This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Take all of your gout medications as directed.

To make sure colchicine and probenecid is safe for you, tell your doctor if you have:

It is not known whether colchicine and probenecid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether colchicine and probenecid passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the side effects of this medication.

How should I take colchicine and probenecid?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take colchicine and probenecid in larger or smaller amounts or for longer than recommended.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using colchicine and probenecid.

You may take this medicine with food or milk if it upsets your stomach. You may also use an antacid.

You may not notice the effects of this medicine right away. Your gout attacks should occur less often as you continue to take colchicine and probenecid. Taking the medicine for several months may cause the attacks to stop altogether. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Drink several full glasses of water every day to prevent kidney stones. Follow your doctor's instructions about the type and amount of liquids you should drink each day.

Your doctor will need to check your progress while you are using colchicine and probenecid.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking colchicine and probenecid?

Avoid drinking alcohol, which can raise uric acid levels in your blood and may also increase your risk of stomach problems caused by colchicine and probenecid.

Colchicine and probenecid side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Colchicine and probenecid may cause serious side effects. Stop using colchicine and probenecid and call your doctor at once if you have:

  • painful urination, severe pain in your side or lower back, blood in your urine, little or no urinating;

  • fever, severe muscle weakness, mood changes, seizure (convulsions);

  • easy bruising or bleeding, unusual weakness; or

  • severe diarrhea, nausea, vomiting, or stomach pain.

Common side effects of colchicine and probenecid may include:

  • mild nausea or stomach pain, loss of appetite;

  • headache;

  • dizziness;

  • hair loss; or

  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Colchicine and probenecid dosing information

Usual Adult Dose for Gouty Arthritis:

Initial: 1 tablet orally once a day for 1 week
Maintenance: 1 tablet orally twice a day
-If symptoms of gouty arthritis are not controlled or 24-hour uric acid excretion is not above 700 mg, may increase dose in 1 tablet increments every 4 weeks as tolerated
Maximum dose: 4 tablets per day

-One tablet contains probenecid 500 mg-colchicine 0.5 mg.
-Therapy should not be started until an acute gouty attack has subsided; if an acute attack is precipitated during therapy, this drug may be continued without changing the dose; additional colchicine or other appropriate therapy should be given to control the acute attack.
-To prevent crystallization of uric acid in urine, a liberal fluid intake (2 L/day) and alkalization of the urine should be encouraged; alkalization of urine may be relaxed when serum urate levels return to normal limits and tophaceous deposits disappear.
-The maintenance dose may be decreased in increments of 1 tablet every 6 months when acute attacks have been absent for 6 months or more and serum urate levels remain within normal limits; maintenance dosage should not be reduced to the point serum urate levels start to rise.

Use: For the treatment of chronic gouty arthritis complicated by frequent, recurrent acute attacks of gout.

What other drugs will affect colchicine and probenecid?

Other drugs may interact with colchicine and probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.