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Colchicine / probenecid Side Effects

For the Consumer

Applies to colchicine / probenecid: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking colchicine / probenecid: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have:

  • painful urination, severe pain in your side or lower back, blood in your urine, little or no urinating;

  • fever, severe muscle weakness, mood changes, seizure (convulsions);

  • easy bruising or bleeding, unusual weakness; or

  • severe diarrhea, nausea, vomiting, or stomach pain.

Common side effects may include:

  • mild nausea or stomach pain, loss of appetite;

  • headache;

  • dizziness;

  • hair loss; or

  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to colchicine / probenecid: oral tablet

Nervous system

Probenecid:
Frequency not reported: Headache, dizziness

Colchicine:
Frequency not reported: Peripheral neuritis[Ref]

Gastrointestinal

Probenecid:
Frequency not reported: Nausea, vomiting, abdominal pain, anorexia, sore gums

Colchicine:
Frequency not reported: Nausea, vomiting, abdominal pain, or diarrhea (may be particularly troublesome in the presence of peptic ulcer or spastic colon)[Ref]

Renal

Probenecid:
Frequency not reported: Nephrotic syndrome, renal colic

Colchicine:
Frequency not reported: Renal damage with hematuria and oliguria have occurred with toxic doses

Hematologic

Probenecid:
Frequency not reported: Leukopenia, aplastic anemia, hemolytic anemia (may be due to genetic deficiency of glucose 6 phosphate dehydrogenase) and anemia

Colchicine:
Frequency not reported: Thrombocytopenia, pancytopenia, leukopenia, agranulocytosis, bone marrow failure, disseminated intravascular coagulation, aplastic anemia[Ref]

Hepatic

Probenecid:
Frequency not reported: Hepatic necrosis.

Hypersensitivity

Probenecid:
Frequency not reported: Anaphylaxis, fever, urticaria, pruritus

Colchicine:
Frequency not reported: Urticaria[Ref]

Dermatologic

Probenecid:
Frequency not reported: Dermatitis, alopecia, flushing

Colchicine:
Frequency not reported: Dermatitis, purpura, alopecia[Ref]

Metabolic

Probenecid:
Frequency not reported: Precipitation of acute gouty arthritis[Ref]

Musculoskeletal

Colchicine:
Frequency not reported: Muscular weakness[Ref]

Genitourinary

Probenecid:
Frequency not reported: Urinary frequency, azoospermia, uric acid stones with or without hematuria, costovertebral pain[Ref]

Other

At toxic doses, other side effects associated with colchicine have included severe diarrhea, generalized vascular damage, and renal damage with hematuria and oliguria.[Ref]

References

1. "Product Information. Colchicine-Probenecid (colchicine-probenecid)." Watson Pharmaceuticals, Corona, CA.

Not all side effects for colchicine / probenecid may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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