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Proben-C Side Effects

Generic name: colchicine / probenecid

Medically reviewed by Last updated on Sep 1, 2020.

Note: This document contains side effect information about colchicine / probenecid. Some of the dosage forms listed on this page may not apply to the brand name Proben-C.

For the Consumer

Applies to colchicine/probenecid: oral tablet

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • A burning, numbness, or tingling feeling that is not normal.
  • Very upset stomach or throwing up.
  • Severe diarrhea.
  • Back pain, belly pain, or blood in the urine. May be signs of a kidney stone.
  • Not able to pass urine or change in how much urine is passed.
  • Any unexplained bruising or bleeding.
  • Feeling very tired or weak.
  • Pale skin.
  • Very bad muscle problems have happened with this drug. This can also lead to kidney problems. Tell your doctor if you have muscle pain or weakness, especially if you feel very tired or weak or have a fever. Tell your doctor if you are not able to pass urine or you have a change in how much urine is passed.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to colchicine / probenecid: oral tablet

Nervous system


Frequency not reported: Headache, dizziness


Frequency not reported: Peripheral neuritis[Ref]



Frequency not reported: Nausea, vomiting, abdominal pain, anorexia, sore gums


Frequency not reported: Nausea, vomiting, abdominal pain, or diarrhea (may be particularly troublesome in the presence of peptic ulcer or spastic colon)[Ref]



Frequency not reported: Nephrotic syndrome, renal colic


Frequency not reported: Renal damage with hematuria and oliguria have occurred with toxic doses



Frequency not reported: Leukopenia, aplastic anemia, hemolytic anemia (may be due to genetic deficiency of glucose 6 phosphate dehydrogenase) and anemia


Frequency not reported: Thrombocytopenia, pancytopenia, leukopenia, agranulocytosis, bone marrow failure, disseminated intravascular coagulation, aplastic anemia[Ref]



Frequency not reported: Hepatic necrosis.



Frequency not reported: Anaphylaxis, fever, urticaria, pruritus


Frequency not reported: Urticaria[Ref]



Frequency not reported: Dermatitis, alopecia, flushing


Frequency not reported: Dermatitis, purpura, alopecia[Ref]



Frequency not reported: Precipitation of acute gouty arthritis[Ref]



Frequency not reported: Muscular weakness[Ref]



Frequency not reported: Urinary frequency, azoospermia, uric acid stones with or without hematuria, costovertebral pain[Ref]


At toxic doses, other side effects associated with colchicine have included severe diarrhea, generalized vascular damage, and renal damage with hematuria and oliguria.[Ref]


1. "Product Information. Colchicine-Probenecid (colchicine-probenecid)." Watson Pharmaceuticals, Corona, CA.

More about Proben-C (colchicine / probenecid)

Consumer resources

Other brands
Probenecid and Colchicine

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.