Prialt Side Effects

Generic name: ziconotide

Medically reviewed by Drugs.com. Last updated on Oct 27, 2022.

Note: This document contains side effect information about ziconotide. Some dosage forms listed on this page may not apply to the brand name Prialt.

Summary

Common side effects of Prialt include: abnormal gait, aphasia, asthenia, dizziness, memory impairment, speech disturbance, ataxia, hypertonia, visual disturbance, and anorexia. Other side effects include: hallucination, nystagmus disorder, urinary retention, vertigo, abnormality in thinking, dysesthesia, fever, and paresthesia. Continue reading for a comprehensive list of adverse effects.

Applies to ziconotide: intrathecal solution.

Warning

Intrathecal route (Solution)

Ziconotide is contraindicated in patients with a preexisting history of psychosis. Severe psychiatric symptoms and neurological impairment may occur during treatment with ziconotide. Monitor all patients frequently for evidence of cognitive impairment, hallucinations, or changes in mood or consciousness. Discontinue ziconotide therapy in the event of serious neurological or psychiatric signs or symptoms.

Serious side effects of Prialt

Along with its needed effects, ziconotide (the active ingredient contained in Prialt) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ziconotide:

More common

Anxiety
being forgetful
change in walking and balance
changes in patterns and rhythms of speech
clumsiness or unsteadiness
confusion
decrease in the frequency of urination
decrease in urine volume
delusions
dementia
difficulty in passing urine (dribbling)
difficulty with speaking
feeling unusually cold
painful urination
problems with speech or speaking
seeing, hearing, or feeling things that are not there
shakiness and unsteady walk
shakiness in the legs, arms, hands, or feet
shivering
slurred speech
thoughts of killing oneself
trembling or shaking of the hands or feet
uncontrolled eye movements
unsteadiness, trembling, or other problems with muscle control or coordination

Less common

Aggressive or angry
chest pain
chills
confusion as to time, place, or person
convulsions
cough
dark-colored urine
dizziness
drowsiness
fainting
fast heartbeat
fearfulness, suspiciousness, or other mental changes
feeling that others are watching you or controlling your behavior
feeling that others can hear your thoughts
fever
general feeling of illness
holding false beliefs that cannot be changed by fact
lightheadedness
muscle spasm or jerking of all extremities
muscle stiffness
rapid, shallow breathing
severe mood or mental changes
shortness of breath
sneezing
sore throat
stiff neck or back
tightness in the chest
troubled breathing
trouble in concentration
trouble in sleeping
unusual behavior unusual excitement, nervousness, or restlessness
unusual tiredness or weakness
wheezing

Rare

Actions that are out of control
changes in behavior
irritability
talking, feeling, and acting with excitement

Incidence not known

Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Get emergency help immediately if any of the following symptoms of overdose occur while taking ziconotide:

Symptoms of overdose

Decreased awareness or responsiveness
severe sleepiness

Other side effects of Prialt

Some side effects of ziconotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blurred vision
crawling feelings
diarrhea
dizziness
dizziness or lightheadedness
excessive muscle tone, tension, or tightness
feeling of constant movement of self or surroundings
headache
itching
lack or loss of strength
loss of appetite
loss of memory
nausea
pain in the arms or legs
problems with memory
sensation of spinning
sleepiness or unusual drowsiness
vomiting
weight loss

Less common

Acid or sour stomach
back pain
bad, unusual, or unpleasant (after) taste
belching
bladder pain
bloody or cloudy urine
bruising
change in taste
congestion
constipation
continuing ringing or buzzing or other unexplained noise in the ears
crying
dehydration
depersonalization
depression
difficulty seeing at night
difficulty with moving
double vision
dry mouth
dry skin
dysphoria
euphoria
fainting
frequent urge to urinate
hearing loss
heartburn
hoarseness
increased sensitivity of the eyes to sunlight
increased sensitivity to pain or touch
indigestion
loss of bladder control
loss of taste
lung disorder
nerve pain
pain in the joints
pain or tenderness around the eyes and cheekbones
pale skin
pounding in the ears
quick to react or overreact emotionally
rapidly changing moods
red, scaly, swollen, or peeling areas of the skin
redness or pain at the catheter site
runny nose
severe muscle stiffness
shortness of breath or troubled breathing
sleeplessness
slow or fast heartbeat
stomach discomfort, upset, or pain
stuffy nose
sweating
swelling or redness in the joints
tender, swollen glands in the neck
tightness of the chest or wheezing
trouble with swallowing
unusual bleeding or bruising
unusual tiredness or weakness
voice changes
warmth on the skin
weakness or heaviness in the legs

Incidence not known

Burning sensation on the skin
flaking and falling off of skin
skin blisters
sores on the skin

For Healthcare Professionals

Applies to ziconotide: intrathecal solution.

General

The most common reported adverse reactions have included dizziness, nausea, confusional state, and nystagmus.^[Ref]

Psychiatric

Very common (10% or more): Confusional state (15%)

Common (1% to 10%): Amnesia, memory impairment, anxiety, insomnia, agitation, cognitive disorder, depression, depression aggravated, disorientation, hallucination, hallucination auditory, hallucination visual, irritability, mood disorder, nervousness, paranoia

Uncommon (0.1% to 1%): Suicide attempt

Frequency not reported: Psychotic disorder, suicidal ideation^[Ref]

Psychotic disorder and suicide ideation occurred in less than 2% of patients; suicide attempt was reported in less than 1% of patients; these events were assessed by clinical investigators as related to drug therapy.^[Ref]

Nervous system

Very common (10% or more): Dizziness, (40%), ataxia (14%), headache (13%), somnolence (17%)

Common (1% to 10%): dysarthria, dysgeusia, nystagmus, tremor, aphasia, areflexia, balance impaired, burning sensation, coordination abnormal, disturbance in attention, dizziness postural, hypnoanesthesia, mental impairment, paresthesia, sedation, speech disorder

Frequency not reported: Cerebrovascular accident, meningitis, stupor, loss of consciousness, clonic convulsion and grandmal convulsion^[Ref]

Cerebrovascular accident, meningitis, stupor, loss of consciousness, clonic convulsion and grandmal convulsion occurred in less than 2% of patients; these events were assessed by clinical investigators as related to drug therapy.^[Ref]

Musculoskeletal

Rhabdomyolysis occurred in less than 2% of patients and was assessed by clinical investigators as related to drug therapy^[Ref]

Very common (10% or more): Abnormal gait (14%)

Common (1% to 10%): Muscle spasms, pain in limb, increased blood creatine phosphokinase, muscle cramp, muscle weakness, myalgia

Frequency not reported: Rhabdomyolysis^[Ref]

Immunologic

Frequency not reported: Sepsis

Sepsis occurred in less than 2% of patients and was assessed by clinical investigators as related to drug therapy.

Gastrointestinal

Very common (10% or more): Nausea (40%), diarrhea (18%), vomiting (16%)

Common (1% to 10%): Abdominal pain, constipation, dry mouth, nausea aggravated^[Ref]

Dermatologic

Common (1% to 10%): Pruritus, increased sweating

Postmarketing reports: Hypersensitivity reactions including angioedema, serious skin reactions including bullous dermatitis, skin ulcers, skin exfoliation, and burning skin sensation^[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity reactions including angioedema, serious skin reactions including bullous dermatitis, skin ulcers, skin exfoliation, and burning skin sensation

Ocular

Common (1% to 10%): Blurred vision, diplopia, visual disturbance^[Ref]

Cardiovascular

Atrial fibrillation and abnormal electrocardiogram were reported in less than 2% of patient; these events were assessed by clinical investigators as related to drug therapy.^[Ref]

Common (1% to 10%): Peripheral edema, hypotension, orthostatic hypotension

Frequency not reported: Atrial fibrillation^[Ref]

Metabolic

Common (1% to 10%): Anorexia, decreased appetite^[Ref]

Respiratory

Respiratory side effects including bronchitis, increased cough, dyspnea, lung disorder, pharyngitis, pneumonia, rhinitis, and sinusitis have been reported in at least 2% of patients participating in the clinical trials. Respiratory distress has been reported in less than 2% of patients participating in the clinical trials. Fatal aspiration pneumonia has been reported in less than 1% of patients participating in clinical trials.^[Ref]

Respiratory distress occurred in less than 2% of patients; Fatal aspiration pneumonia was reported in less than 1% of patients; these were assessed by clinical investigators as related to drug therapy.^[Ref]

Other

Very common (10% or more): Asthenia (18%)

Common (1% to 10%): Vertigo, pyrexia, rigors, fall, fatigue, lethargy^[Ref]

Renal

Acute renal failure occurred in less than 2% of patients and was assessed by clinical investigators as related to drug therapy.^[Ref]

Renal side effects including urinary retention (9%) have been reported. Urinary incontinence, urinary tract infection, and impaired urination have been reported in at least 2% of patients participating in the clinical trials. Acute kidney failure has been reported in less than 2% of patients participating in the clinical trials.^[Ref]