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Prepopik Side Effects

Generic Name: citric acid / magnesium oxide / sodium picosulfate

Note: This page contains side effects data for the generic drug citric acid / magnesium oxide / sodium picosulfate. It is possible that some of the dosage forms included below may not apply to the brand name Prepopik.

For the Consumer

Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for solution

As well as its needed effects, citric acid / magnesium oxide / sodium picosulfate may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking citric acid / magnesium oxide / sodium picosulfate, check with your doctor immediately:

Incidence not known:
  • Bloody stools
  • confusion
  • convulsions
  • decreased urine output
  • dizziness or fainting
  • dry mouth
  • fast, slow, or irregular heartbeat
  • fever
  • headache
  • hives, itching or skin rash
  • jerking or shaking of the muscles
  • joint pain, stiffness, or swelling
  • muscle pain or cramps
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red or purple spots on the skin
  • shortness of breath
  • swelling of the eyelids, face, lips, ankles, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for reconstitution


Cardiovascular side effects have included headache (up to 8%).[Ref]


Gastrointestinal side effects have included nausea (up to 11%). A certain amount of abdominal bloating, distention, pain/cramping, and watery diarrhea are expected as a consequence of the mechanism of action of citric acid/Mg oxide/Na picosulfate and should be expected. Gastrointestinal side effects reported postmarketing have included abdominal pain, diarrhea, fecal incontinence, and proctalgia. There have been isolated reports of reversible aphthoid ileal ulcers.[Ref]


Hypersensitivity side effects reported postmarketing have included rash, urticaria, and purpura.[Ref]


Metabolic side effects have included electrolyte imbalances including hypokalemia, hyponatremia, and hypermagnesemia.[Ref]


1. "Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate)." Ferring Pharmaceuticals Inc, Tarrytown, NY.

It is possible that some side effects of Prepopik may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Prepopik (citric acid / magnesium oxide / sodium picosulfate)

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