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Prepopik Side Effects

Generic Name: citric acid / magnesium oxide / sodium picosulfate

Note: This document contains side effect information about citric acid / magnesium oxide / sodium picosulfate. Some of the dosage forms listed on this page may not apply to the brand name Prepopik.

For the Consumer

Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for solution, oral solution

Along with its needed effects, citric acid/magnesium oxide/sodium picosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking citric acid / magnesium oxide / sodium picosulfate:

Incidence Not Known

  • Bleeding of the rectum
  • bloody stools
  • confusion
  • decreased urine output
  • diarrhea
  • dizziness or fainting
  • dry mouth
  • fast, slow, or irregular heartbeat
  • fever
  • headache
  • hives, itching, skin rash
  • increased thirst
  • jerking or shaking of the muscles
  • joint pain, stiffness, or swelling
  • loss of bowel control
  • loss of consciousness
  • muscle pain or cramps
  • nausea
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red or purple spots on the skin
  • seizures
  • stomach pain and tenderness
  • swelling of the eyelids, face, lips, ankles, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness
  • vomiting

Some side effects of citric acid / magnesium oxide / sodium picosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence Not Known

  • Pain in the rectum

For Healthcare Professionals

Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for reconstitution, oral solution


Cardiovascular side effects have included headache (up to 8%).[Ref]


Gastrointestinal side effects have included nausea (up to 11%). A certain amount of abdominal bloating, distention, pain/cramping, and watery diarrhea are expected as a consequence of the mechanism of action of citric acid/Mg oxide/Na picosulfate and should be expected. Gastrointestinal side effects reported postmarketing have included abdominal pain, diarrhea, fecal incontinence, and proctalgia. There have been isolated reports of reversible aphthoid ileal ulcers.[Ref]


Hypersensitivity side effects reported postmarketing have included rash, urticaria, and purpura.[Ref]


Metabolic side effects have included electrolyte imbalances including hypokalemia, hyponatremia, and hypermagnesemia.[Ref]


1. "Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate)." Ferring Pharmaceuticals Inc, Tarrytown, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Prepopik (citric acid / magnesium oxide / sodium picosulfate)

Consumer resources

Other brands: Clenpiq

Professional resources

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