Poteligeo Side Effects

Generic name: mogamulizumab

Medically reviewed by Drugs.com. Last updated on Jan 17, 2023.

Note: This document contains side effect information about mogamulizumab. Some dosage forms listed on this page may not apply to the brand name Poteligeo.

Applies to mogamulizumab: intravenous solution.

Serious side effects of Poteligeo

Along with its needed effects, mogamulizumab (the active ingredient contained in Poteligeo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking mogamulizumab:

More common

Black, tarry stools
bladder pain
bleeding gums
blood in the urine or stools
cloudy urine
blurred vision
body aches or pain
burning, dry, or itching eyes
burning, itching, and pain in hairy areas, pus at the root of the hair
burning, numbness, tingling, or painful sensations
chest pain
chills
cough
cracked lips
decreased frequency or amount of urine
diarrhea
difficult or labored breathing
difficult, burning, or painful urination
difficulty in swallowing
discharge, excessive tearing
dizziness
drowsiness
dry mouth
ear congestion
fainting
fast, slow, or irregular heartbeat
fever
flushed, dry skin
frequent urge to urinate
fruit-like breath odor
headache
increased hunger
increased thirst
increased urination
itching, skin rash
joint pain, stiffness, or swelling
loss of appetite
loss of voice
lower back, side, or stomach pain
mood or mental changes
muscle and bone pain
muscle spasms (tetany) or twitching seizures
nasal congestion
nausea
nervousness
pale skin
pinpoint red spots on the skin
pounding in the ears
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
runny nose
skin blisters
sneezing
sore throat
sores, ulcers, or white spots on the lips, tongue, or inside the mouth
stomach pain
swelling of the face, fingers, lower legs, or feet
tenderness
tightness in the chest
trembling
troubled breathing with exertion
unexplained weight loss
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
vomiting
warmth on skin
weakness in the arms, hands, legs, or feet
weight gain

Less common

Burning or stinging of the skin
earache
painful cold sores or blisters on the lips, nose, eyes, or genitals
redness or swelling in the ear

Rare

Chest discomfort
dilated neck veins
extreme tiredness or weakness
irregular breathing
pain or discomfort in the arms, jaw, back, or neck

Incidence not known

Dark urine
general tiredness and weakness
light-colored stools
upper right abdominal pain
yellow eyes and skin

Other side effects of Poteligeo

Some side effects of mogamulizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation
decreased appetite
discouragement
falls
feeling sad or empty
irritability
loss of interest or pleasure
thinning or loss of hair
trouble concentrating
trouble sleeping

For Healthcare Professionals

Applies to mogamulizumab: intravenous solution.

Hematologic

Very common (10% or more): Thrombocytopenia (14%), anemia (12%)^[Ref]

Immunologic

Common (1% to 10%): Candidiasis, urinary tract infection, folliculitis, pneumonia, otitis, herpesvirus infection

Postmarketing reports: Hepatitis B virus reactivation^[Ref]

Local

Very common (10% or more): Infusion reaction (33%)^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (e.g., back pain, bone pain, musculoskeletal chest pain, musculoskeletal pain, myalgia, neck pain, pain in extremity) (22%)

Common (1% to 10%): Muscle spasm^[Ref]

Ocular

Common (1% to 10%): Conjunctivitis^[Ref]

Metabolic

Very common (10% or more): Albumin decreased (34%), calcium decreased (30%), uric acid increased (29%), phosphate decreased (27%)

Common (1% to 10%): Hyperglycemia, hyperuricemia, hypomagnesemia, weight gain, weight loss, anorexia^[Ref]

Psychiatric

Common (1% to 10%): Insomnia, depression^[Ref]

Oncologic

Uncommon (0.1% to 1%): Tumor lysis syndrome

Respiratory

Very common (10% or more): Upper respiratory tract infection (e.g., laryngitis viral, nasopharyngitis, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, viral upper respiratory tract infection) (22%), cough (11%)

Common (1% to 10%): Dyspnea^[Ref]

Other

Very common (10% or more): Fatigue (31%), pyrexia (17%), edema (16%)

Common (1% to 10%): Chills, fall^[Ref]

General

The most common adverse reactions (reported in 20% or more of patients)

were rash (including drug eruption), infusion related reactions, fatigue, diarrhea, upper respiratory tract infection. and musculoskeletal pain. Adverse reactions reported in 10% or more of patients included skin infection, pyrexia, nausea,

edema, thrombocytopenia, headache, constipation, mucositis, anemia, cough, and hypertension.^[Ref]

Nervous system

Very common (10% or more): Headache (14%)

Common (1% to 10%): Dizziness, peripheral neuropathy^[Ref]

Renal

Common (1% to 10%): Renal insufficiency^[Ref]

Cardiovascular

Very common (10% or more): Hypertension (10%)

Common (1% to 10%): Arrhythmia

Uncommon (0.1% to 1%): Myocardial infarction, myocardial infarction, cardiac failure

Postmarketing reports: Stress cardiomyopathy^[Ref]

Dermatologic

Very common (10% or more): Rash (dermatitis [e.g., allergic, atopic, bullous, contact, exfoliative, infected); drug eruption [e.g., palmoplantar keratoderma]; rash [e.g., generalized, macular, maculopapular, papular, pruritic, pustular]; skin reaction [e.g., toxic skin eruption]) (35%), drug eruption (24%), skin infection (e.g., cellulitis, dermatitis infected, erysipelas, impetigo, infected skin ulcer, periorbital cellulitis, skin bacterial infection, skin infection, staphylococcal skin infection) (22%)

Common (1% to 10%): Xerosis, alopecia^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (28%), mucositis (e.g., aphthous stomatitis, mouth ulceration, mucosal inflammation, oral discomfort, oral pain, oropharyngeal pain, stomatitis) (17%), nausea (16%), constipation (13%)

Common (1% to 10%): Vomiting, abdominal pain^[Ref]