Pirtobrutinib Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 23, 2023.

Applies to pirtobrutinib: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting this medicine. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 1 week after your last dose. If you think you have become pregnant while using the medicine, tell your doctor right away.

Call your doctor right away if you start to have a cough that would not go away, weight loss, night sweats, fever, chills, flu-like symptoms (eg, runny or stuffy nose, headache, blurred vision, or feeling generally ill), painful or difficult urination, or sores, ulcers, or white spots in the mouth or on the lips. These may be signs that you have an infection.

Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal. These may be signs of bleeding problems.

Pirtobrutinib may lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

This medicine may cause heart rhythm problems (eg, atrial flutter, atrial fibrillation). Check with your doctor right away if you have a fast or irregular heartbeat, trouble breathing, lightheadedness, dizziness, or fainting.

Using this medicine may increase your risk of getting new cancers, including skin cancer. Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before and after having surgery.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of pirtobrutinib

Along with its needed effects, pirtobrutinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pirtobrutinib:

Other side effects of pirtobrutinib

Some side effects of pirtobrutinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to pirtobrutinib: oral tablet.

General adverse events

The most common adverse reactions reported were decreased neutrophils, hemoglobin, platelets, and lymphocytes, as well as fatigue, musculoskeletal pain, bruising, diarrhea, edema, dyspnea, and pneumonia.^[Ref]

Dermatologic

• Very common (10% or more): Rash (14%)^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (19%), constipation (13%), abdominal pain (11%), nausea (11%)^[Ref]

Hematologic

• Very common (10% or more): Hemorrhage (11%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (27%), arthritis/arthralgia (up to 12%)^[Ref]

Nervous system

• Very common (10% or more): Peripheral neuropathy (14%), dizziness (10%)
• Frequency not reported: Memory changes, headache^[Ref]

Ocular

• Frequency not reported: Vision changes^[Ref]

Oncologic

• Frequency not reported: Tumor lysis syndrome^[Ref]

Other

• Very common (10% or more): Fatigue (29%), edema (18%), fever (13%), pneumonia (16%), upper respiratory tract infections (10%), bruising (16%), decreased hemoglobin (42%), decreased platelet count (39%), decreased neutrophil count (36%), decreased lymphocyte count (32%), increased creatinine (30%), decreased calcium (19%), increased aspartate aminotransferase (AST) (17%), increased alanine transaminase (ALT) (11%), decreased potassium (13%), increased potassium (11%), decreased sodium (13%), increased lipase (12%), increased alkaline phosphatase (11%)
• Common (1% to 10%): Sepsis (2.3%)
• Frequency not reported: Urinary tract infection, herpes virus infection^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (17%), cough (14%)
• Common (1% to 10%): Pleural effusion (2.3%)^[Ref]

See also:

Further information

Pirtobrutinib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer