Skip to Content

Pimavanserin Side Effects

In Summary

More frequently reported side effects include: peripheral edema. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pimavanserin: oral tablet

Along with its needed effects, pimavanserin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pimavanserin:

Incidence not known

  • Chest pain or discomfort
  • fainting
  • irregular or slow heart rate
  • shortness of breath

Some side effects of pimavanserin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • confusion
  • nausea
  • rapid weight gain
  • unusual weight gain or loss

Less common

  • Change in walking and balance
  • clumsiness or unsteadiness
  • difficulty having a bowel movement (stool)

For Healthcare Professionals

Applies to pimavanserin: oral tablet

General

The most commonly reported side effects are peripheral edema and confusional state.[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, nausea
Postmarketing reports: Tongue swelling[Ref]

Psychiatric

Common (1% to 10%): Confusional state, hallucinations[Ref]

Hallucinations included visual, auditory, tactile, and somatic hallucinations.[Ref]

Cardiovascular

Common (1% to 10%): Peripheral edema
Frequency not reported: QT interval prolongation[Ref]

Nervous system

Common (1% to 10%): Gait disturbance[Ref]

Other

Common (1% to 10%): Fatigue[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Dermatologic

Postmarketing reports: Circumoral edema, rash, urticaria[Ref]

Hypersensitivity

Postmarketing reports: Angioedema[Ref]

Respiratory

Postmarketing reports: Dyspnea, throat tightness[Ref]

References

1. "Product Information. Nuplazid (pimavanserin)." Accelis Pharma, East Windsor, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Hide