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Pimavanserin Side Effects

For the Consumer

Applies to pimavanserin: oral tablet

As well as its needed effects, pimavanserin may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking pimavanserin, check with your doctor immediately:

Incidence not known:
  • Chest pain or discomfort
  • fainting
  • irregular or slow heart rate
  • shortness of breath

Minor Side Effects

Some pimavanserin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • confusion
  • nausea
  • rapid weight gain
  • unusual weight gain or loss
Less common:
  • Change in walking and balance
  • clumsiness or unsteadiness
  • difficulty having a bowel movement (stool)

For Healthcare Professionals

Applies to pimavanserin: oral tablet


The most commonly reported side effects are peripheral edema and confusional state.[Ref]


Hallucinations (e.g., visual, auditory, tactile, and somatic)[Ref]

Common (1% to 10%): Confusional state, hallucinations[Ref]


Common (1% to 10%): Nausea, constipation[Ref]


Common (1% to 10%): Peripheral edema[Ref]

Nervous system

Common (1% to 10%): Gait disturbance[Ref]


Common (1% to 10%): Fatigue[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


1. "Product Information. Nuplazid (pimavanserin)." Accelis Pharma, East Windsor, NJ.

It is possible that some side effects of pimavanserin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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