Pimavanserin Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 15, 2023.

Applies to pimavanserin: oral capsule, oral tablet.

Serious side effects of Pimavanserin

Along with its needed effects, pimavanserin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pimavanserin:

Incidence not known

• Chest pain, discomfort, or tightness
• fainting
• irregular or slow heart rate
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
• trouble breathing

Other side effects of Pimavanserin

Some side effects of pimavanserin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• confusion
• constipation
• nausea
• rapid weight gain
• unusual weight gain or loss

Less common

• Change in walking and balance
• clumsiness or unsteadiness
• difficulty having a bowel movement

Incidence not known

• Sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to pimavanserin: oral capsule, oral tablet.

General

The most commonly reported side effects are peripheral edema and confusional state.^[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, nausea

Postmarketing reports: Tongue swelling^[Ref]

Psychiatric

Hallucinations included visual, auditory, tactile, and somatic hallucinations.^[Ref]

Common (1% to 10%): Confusional state, hallucinations^[Ref]

Cardiovascular

Common (1% to 10%): Peripheral edema

Frequency not reported: QT interval prolongation^[Ref]

Nervous system

Common (1% to 10%): Gait disturbance^[Ref]

Other

Common (1% to 10%): Fatigue^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection^[Ref]

Dermatologic

Postmarketing reports: Circumoral edema, rash, urticaria^[Ref]

Hypersensitivity

Postmarketing reports: Angioedema^[Ref]

Respiratory

Postmarketing reports: Dyspnea, throat tightness^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer