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Pimavanserin Dosage

Applies to the following strengths: 17 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Psychosis

Recommended dose: 34 mg (as two 17 mg tablets) orally once a day

-This drug does not require titration.

Use: Treatment of hallucinations and delusions associated with Parkinson's disease psychosis

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 mL/min and greater): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended.

Liver Dose Adjustments

Not recommended.

Dose Adjustments

Use with concurrent strong CYP450 3A4 inhibitors:
-Recommended dose: 17 mg orally once a day

Use with concurrent strong CYP450 3A4 inducers:
-Monitor for reduced efficacy; the dose of this drug may need to be increased


US BOXED WARNING: This drug has an increased risk of mortality when administered to elderly patients with dementia-related psychosis. Elderly patients with dementia-related psychosis treated with antipsychotic drugs have an increased risk of death. This drug is not approved for use in patients with dementia-related psychosis unrelated to hallucinations and delusions associated with Parkinson's disease psychosis.

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:
-May be taken with or without food

Patient advice:
-Patients should be advised to report all concurrent prescription and nonprescription medications or herbal products they are taking.
-Patients should be advised to speak to a healthcare provider if pregnant, intend to become pregnant, or are breastfeeding.