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Pimavanserin Dosage

Medically reviewed on July 20, 2018.

Applies to the following strengths: 10 mg; 17 mg; 34 mg

Usual Adult Dose for Psychosis

34 mg (as two 17 mg tablets) orally once a day

Comment: This drug does not require titration.

Use: Treatment of hallucinations and delusions associated with Parkinson's disease psychosis

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 mL/min and greater): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended.

Liver Dose Adjustments

Not recommended.

Dose Adjustments

Use with concurrent strong CYP450 3A4 inhibitors: 17 mg orally once a day

Use with concurrent strong CYP450 3A4 inducers:
-Monitor for reduced efficacy; the dose of this drug may need to be increased

Precautions

US BOXED WARNINGS:
INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS:
-Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
-This drug is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson's disease psychosis.

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-May be taken with or without food

Patient advice:
-Patients should be advised to report all concurrent prescription and nonprescription medications or herbal products they are taking.
-Patients should be advised to speak to a healthcare provider if pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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