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Pimavanserin

Generic Name: pimavanserin (PIM a VAN ser in )
Brand Name: Nuplazid

Medically reviewed on July 20, 2018

What is pimavanserin?

Pimavanserin is an antipsychotic medicine that works by changing the actions of chemicals in the brain.

Pimavanserin is used to treat hallucinations and delusions caused by psychosis that is related to Parkinson's disease.

Pimavanserin may also be used for purposes not listed in this medication guide.

Important Information

Pimavanserin may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

Before taking this medicine

Pimavanserin may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

You should not use pimavanserin if you are allergic to it.

Tell your doctor if you have ever had:

  • a heart rhythm disorder;

  • long QT syndrome (in you or a family member);

  • kidney disease; or

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

It is not known whether pimavanserin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I take pimavanserin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take pimavanserin with or without food.

When you start or stop taking other medicines, your doctor may need to adjust your pimavanserin dose.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause nausea and vomiting.

What should I avoid while taking pimavanserin?

Avoid drinking alcohol. Dangerous side effects could occur.

Pimavanserin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or pounding heartbeats, fluttering in your chest;

  • shortness of breath; or

  • sudden dizziness (like you might pass out).

Common side effects may include:

  • confusion; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Pimavanserin dosing information

Usual Adult Dose for Psychosis:

34 mg (as two 17 mg tablets) orally once a day

Comment: This drug does not require titration.

Use: Treatment of hallucinations and delusions associated with Parkinson's disease psychosis

What other drugs will affect pimavanserin?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Your pimavanserin dose may need to be adjusted if you use certain other medications. It is very important to tell your doctor if you start or stop using any other medications.

Pimavanserin can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect pimavanserin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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